代谢
单次口服给药14C标记的1,2-双(2,4,6-三溴苯氧基)乙烷(BTBPE)给常规雄性Sprague-Dawley大鼠和胆管插管的雄性Sprague-Dawley大鼠。代谢物通过尿液、胆汁和粪便排出,但水平非常低。粪便中的代谢物被鉴定为单羟基化、单羟基化并脱溴、单个芳香环上的二羟基化/脱溴、每个芳香环上的单羟基化伴随脱溴,以及醚键两侧的断裂产生三溴苯酚和三溴苯氧基乙醇。尽管在粪便中可以提取的稳定代谢物数量有限,但不可提取的14C水平相对较高(占0-24小时粪便14C的39%),这表明BTBPE可能在老鼠体内被代谢激活,并与粪便中的蛋白质和/或脂质共价结合。因此,通过哺乳动物摄入,BTBPE的吸收和代谢是有限的。
A single oral dose of (14)C 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) was administered to conventional and bile-duct cannulated male Sprague-Dawley rats. ... Metabolites were excreted in the urine, bile and feces, but at a very low level. Fecal metabolites were characterized as monohydroxylated, monohydroxylated with debromination, dihydroxylated/debrominated on a single aromatic ring, monohydroxylated on each aromatic ring with accompanying debromination, and cleavage on either side of the ether linkage to yield tribromophenol and tribromophenoxyethanol. Despite a limited quantity of stable metabolites extractable in the feces, non-extractable 14C levels were relatively high (39% of the 0-24 hr fecal (14)C), which suggested that BTBPE could be metabolically activated in the rat and covalently bound to fecal proteins and/or lipids. It was concluded that limited absorption and metabolism of BTBPE would occur by ingestion in mammals.
来源:Hazardous Substances Data Bank (HSDB)