1,3-二氢-1-[1-苄基-4-哌啶基]-2H-苯并咪唑-2-酮 | 16148-06-4

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1,3-二氢-1-[1-苄基-4-哌啶基]-2H-苯并咪唑-2-酮
• 英文名称: 3-(1-benzylpiperidin-4-yl)-1H-benzimidazol-2-one
• CAS: 16148-06-4
• 化学式: C₁₉H₂₁N₃O
• 分子量: 307.4
• InChiKey: WMPRRSYNQDCNCE-UHFFFAOYSA-N

物化性质

• 熔点：
  160.8-162 °C
• 密度：
  1?+-.0.06 g/cm3(Predicted)
• 溶解度：
  二氯甲烷、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compounds with Antiparasitic Activity, Applications thereof to the Treatment of Infectious Diseases Caused by Apicomplexans
  申请人：Deligny Michael

  公开号：US20100292214A1

  公开（公告）日：2010-11-18

  The Invention relates to compounds having an antiparasitic activity, and to their use as a drug, in particular as a drug for the prevention and/or treatment of parasitic diseases caused by apicomplexans. The invention also relates to pharmaceutical compositions containing those compounds.

  本发明涉及具有抗寄生活性的化合物及其作为药物的使用，特别是用于预防和/或治疗由顶复门寄生虫引起的寄生虫病。本发明还涉及含有这些化合物的制药组合物。
• 2-OXOIMIDAZOLE DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0990653A1

  公开（公告）日：2000-04-05

  The present invention relates to a compound represented by Formula [I] [wherein represents an aromatic carbo- or heterocyclic ring which may have a substituent; Cy represents a mono-, bi- or tricyclic aliphatic carbocyclic group having 3 to 20 carbon atoms, which may have a substituent; represents a mono- or bicyclic aliphatic nitrogen-containing heterocyclic group having 3 to 14 carbon atoms, which may have a substituent; R1 represents a hydrogen atom, a lower alkenyl group, a lower alkynyl group, a cyclo(lower alkyl) group, an amino group, a lower alkylamino group, a di(lower alkyl)amino group, a hydroxyl group, a lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group or a di(lower alkyl)carbamoyl group, or a lower alkyl group which may have a substituent; and R 2 represents a hydrogen atom or a lower alkyl group], a salt or ester thereof, a production process for the same, and an analgesic, a reliever against tolerance to a narcotic analgesic represented by morphine, a reliever against dependence on a narcotic analgesic represented by morphine, an analgesic enhancer, an antiobestic, a drug for ameliorating brain function, a remedy for schizophrenia, a remedy for Parkinsonism, a remedy for chorea, an antidepressant, a remedy for diabetes insipidus, a remedy for polyuria, or a remedy for hypotension, comprising an effective ingredient of the same.

  本发明涉及一种由式[I]表示的化合物 其中 代表芳香族碳环或杂环，可以有取代基； Cy 代表具有 3 至 20 个碳原子的单环、双环或三环脂族碳环基团，可以有取代基； 代表具有 3 至 14 个碳原子的单环或双环脂族含氮杂环基团，该基团可具有取代基；R1 代表氢原子、低级烯基、低级炔基、环(低级烷基)基团、氨基、低级烷基氨基、二(低级烷基)氨基、羟基、低级烷氧基、羧基、低级烷氧羰基、氨基甲酰基、低级烷基氨基甲酰基或二(低级烷基)氨基甲酰基，或可带有取代基的低级烷基；以及 R 2 代表氢原子或低级烷基]，其盐或酯，其生产工艺，以及一种镇痛剂、一种防止对以吗啡为代表的麻醉性镇痛剂产生耐受性的缓解剂、一种防止对以吗啡为代表的麻醉性镇痛剂产生依赖性的缓解剂、一种镇痛增强剂、一种抗抑郁剂、一种改善脑功能的药物、一种治疗精神分裂症的药物、一种治疗帕金森病的药物、一种治疗舞蹈症的药物、一种抗抑郁剂、一种治疗糖尿病的药物、一种治疗多尿症的药物或一种治疗低血压的药物，其中包括一种有效成分。
• Process for the preparation of pimozide
  申请人：Institut Univ. de Ciència i Tecnologia, S.A.

  公开号：EP2357172B1

  公开（公告）日：2012-10-31
• COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS
  申请人：Commissariat à l'Energie Atomique

  公开号：EP2155676A2

  公开（公告）日：2010-02-24
• US6258825B1
  申请人：——

  公开号：US6258825B1

  公开（公告）日：2001-07-10