1,4,6-环庚三烯-1-甲酰胺 | 100959-82-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1,4,6-环庚三烯-1-甲酰胺
• 英文名称: 2-Carbamoylcycloheptatrien
• 英文别名: Cycloheptatriencarbonsaeure-(2)-amid；cyclohepta-1,4,6-trienecarboxamide；Cyclohepta-1,4,6-triencarbamid；Cyclohepta-1,4,6-triene-1-carboxamide
• CAS: 100959-82-8
• 化学式: C₈H₉NO
• mdl: MFCD18806022
• 分子量: 135.166
• InChiKey: AVHZJNMNRXOVLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,4,6-环庚三烯-1-甲酰胺 、 furan-2,3,5(4H)-trione pyridine (1:1) 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Buchner, Chemische Berichte, 1897, vol. 30, p. 635

  摘要：

  DOI：
• 作为产物：
  描述：

  cycloheptatriene-2-carboxylic acid 生成 1,4,6-环庚三烯-1-甲酰胺
  参考文献：
  名称：

  七叶烯（亚甲基环庚三烯）

  摘要：

  通过在三甲基7-环庚三烯基甲基碘化碘上进行霍夫曼消除反应，合成了具有理论意义的共轭非苯甲酸酯类七氟醚（图2，I）。不可分离，仅在稀溶液中稳定，在催化加氢成甲基环庚烷的基础上，我被赋予了七氟甲醚结构；指示从IR和臭氧分解成甲醛的亚甲基; 精细的可见光谱和紫外线光谱与高度共轭的系统相关联；对酸有明显的敏感性；并与乙炔二羧酸酯反应，得到（最终）a唑衍生物。

  DOI：

  10.1016/0040-4020(60)80069-5

文献信息

• BICYCLIC AMIDES
  申请人：Merck & Co., Inc.

  公开号：EP1499306A2

  公开（公告）日：2005-01-26
• EP1499306A4
  申请人：——

  公开号：EP1499306A4

  公开（公告）日：2007-03-28
• PYRIDONEMORPHINAN ANALOGS AND BIOLOGICAL ACTIVITY ON OPIOID RECEPTORS
  申请人：Purdue Pharma LP

  公开号：EP2931724B1

  公开（公告）日：2017-01-25
• [EN] BICYCLIC AMIDES<br/>[FR] AMIDES BICYCLIQUES
  申请人：MERCK & CO INC

  公开号：WO2003086288A2

  公开（公告）日：2003-10-23

  Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
• [EN] COMPOSITION FOR BRIGHTENING OR WHITENING KERATIN MATERIALS<br/>[FR] COMPOSITION POUR ÉCLAIRCIR OU BLANCHIR DES MATIÈRES KÉRATINIQUES
  申请人：OREAL

  公开号：WO2020132856A1

  公开（公告）日：2020-07-02

  Provided herein is a composition for brightening or whitening keratin materials in the form of an oil-in-water dispersion, comprising an oily phase dispersed in an aqueous phase, and comprising: (i) at least one skin brightening or whitening active ingredient selected from hydroxylated diphenylmethane derivatives; (ii) at least one oil selected from C4-C24 fatty acid ester of glycerol; and (v) at least one hydrophilic thickening agent selected from copolymer obtained from monomers possessing ethylenic unsaturation and possessing a sulpho group and other monomers possessing ethylenic unsaturation without a sulpho group. It also relates to a cosmetic process for brightening or whitening keratin materials, in particular the human skin.