Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect
Skin Sensitizer - An agent that can induce an allergic reaction in the skin.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
... Groups of 60 male and female Sprague-Dawley rats 6-8 weeks of age received topical applications of an oxidative hair-dye formulation (7405) containing 0.4% 2-amino-4-nitrophenol, 6.0% 2,5-diaminoanisole sulfate, 2.0% resorcinol, 0.3% ortho-aminophenol, 5.0% oleic acid, 3.0% isopropanol, 0.2% sodium sulfite, 6.0% ammonia (29%) and water to 100%. The formulation was diluted in an equal volume of 6% hydrogen peroxide, and 0.5 mL was applied to a shaved area of the back (approx. 2.5 cm in diameter) twice a week up to week 117. Mean body weights and survival were similar in treated and control groups. No skin tumors were observed. The incidence of pituitary adenomas was increased in males in comparison with one of the control groups 35/52 (67%) versus 14/49; P < 0.01; X2-test), and no increase in the incidence of tumors at any other site was observed in treated as compared with control animals. ...
/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/
/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/
/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/
Skin absorption of a hair dye product with 2,5-DAA (1.9%, mixed 1:1 with H2O2) applied (27-32 min) on washed hair of 5 female volunteers was less than 0.102% of the amount applied, under hypothesis that distribution of the dye is equal in the whole body.
(14)C-2,5-DAA.2HCl (aqueous solution) applied epicutaneously without hydrogen peroxide on HIM: OFA-Sprague-Dawley rats at 2 mg (free base)/sq cm showed that 1.02% of the amount applied was absorbed. (14)C-2,5-DAA.2HCl in commercial preparation (1;1 with 6% H2O2) after epicutaneous applications on sq cm of clipped skin areas and 2 mg (free base)/sq cm on unclipped skin showed an absorption of 0.28% (clipped skin) and 0.07% (unclipped skin).
A new class of core–shell magnetic gold nanocomposites is prepared in a raspberry‐like fashion by the controlled supramolecular host–guest assembly of γ‐cyclodextrins (γ‐CDs) and boron clusters. In this work, Cs2[closo‐B12H12], a fundamental boron cluster, can play a dual role in the preparation of highly monodispersed Au nanoparticles and in the immobilization of Au nanoparticles on the γ‐CDs@Fe3O4
通过控制γ-环糊精（γ-CDs）和硼团簇的超分子主体-客体组装，以覆盆子状的方式制备了新型的核-壳磁性金纳米复合材料。在这项工作中，基本的硼簇Cs 2 [ closo- B 12 H 12 ]可以在制备高度单分散的Au纳米颗粒以及将Au纳米颗粒固定在γ-CDs@ Fe 3 O 4上起双重作用。表面作为有效的锚点。这种简便而自发的超分子策略可以控制高度稳定的金复合材料的尺寸和组成。此外，获得的AuNPs @ Fe 3 O 4 复合材料具有优异的催化活性和可再循环性，可将硝基芳族化合物选择性还原为相应的苯胺化合物，并且在20 s内即可实现最快的反应，并且在室温下具有较高的转化率和选择性，这比之前在SiO2研究中获得的要好。金属纳米颗粒复合材料作为催化剂。
HAIR COLORING COMPOSITIONS
申请人：——
公开号：US20020032933A1
公开（公告）日：2002-03-21
A hair coloring composition comprising: (a) from about 0.0003 moles (per 100 g of composition) to less than about 0.09 moles (per 100 g of composition) of an inorganic peroxygen oxidizing agent; and (b) an oxidative hair coloring agent; wherein the pH of each of (a) and (b) is in the range of from about 1 to about 6 and wherein the combined mixture of (a) and (b) has a pH in the range of from about 1 to about 6. The products can provide excellent hair coloring and in-use efficacy benefits including excellent initial color and good wash fastness in combination with reduced hair damage at low pH.
A hair colouring and conditioning composition comprising:
(a) a hair colouring agent; and
(b) a hair conditioning agent;
wherein the composition provides an Average Combing Index Value of greater than 1.2 as measured by the Combing Technical Test Method.
The products can provide excellent hair colouring together with excellent conditioning, reduced hair damage, brittleness and dryness, and is convenient and easy to use.
Compositions for oxidatively dyeing keratin fibers and methods for using such compositions
申请人：Lim Mu'Ill
公开号：US20070209123A1
公开（公告）日：2007-09-13
Compositions for dyeing keratin fibers comprise (a) at least one keratin dyeing compound selected from aromatic systems which comprise at least one boronic acid or boronic ester moiety and which are capable of forming upon oxidation a nucleophile or an electrophile, (b) at least one additional keratin dyeing compound selected from the group consisting of auxiliary developers and auxiliary couplers, and (c) a cosmetically suitable medium. Methods for oxidatively dyeing keratin fibers comprise the steps of applying such compositions in the presence of an oxidizing agent and rinsing the hair. A hair coloring product in kit form comprises a first separately packaged container comprising a composition as described above and a second separately packaged container comprising an oxidizing agent.
NOVEL COMPOUND HAVING MULTIMER STRUCTURE OF XANTHENE DERIVATIVE, COLORING COMPOSITION, INK FOR INKJET RECORDING, METHOD OF INKJET RECORDING, COLOR FILTER, AND COLOR TONER
申请人：FUJIFILM CORPORATION
公开号：US20140176653A1
公开（公告）日：2014-06-26
There is provided a compound represented by formula (1):
in formula (1), L represents a divalent to tetravalent linking group; D represents a residue obtained by removing 1 to 5 hydrogen atoms from a compound represented by formula (2); m represents an integer of 1 to 10, however, each L may be the same with or different from every other L; n represents an integer of 2 to 10, however, each D may be the same with or different from every other D; and in formula (2), each of R
4
to R
24
independently represents a hydrogen atom or a substituent, provided that formula (2) has at least one or more ionic hydrophilic groups.
