1,4-二甲基-1,3-二氢-5-苯基-2H-咪唑-2-酮 | 22199-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1,4-二甲基-1,3-二氢-5-苯基-2H-咪唑-2-酮
• 英文名称: 1,4-dimethyl-5-phenyl-1H-imidazol-2(3H)-one
• 英文别名: 3,4-dimethyl-5-phenyl-4-imidazolin-2-one；1,4-dimethyl-5-phenyl-1,3-dihydro-imidazol-2-one；1,4-Dimethyl-5-phenyl-2-imidazolinone；3,5-dimethyl-4-phenyl-1H-imidazol-2-one
• CAS: 22199-48-0
• 化学式: C₁₁H₁₂N₂O
• 分子量: 188.229
• InChiKey: DSBAKUBEPYOCFX-UHFFFAOYSA-N

物化性质

• 密度：
  1.135±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933290090

反应信息

• 作为产物：
  描述：

  1-methyl-3-(1-oxo-1-phenylpropan-2-yl)urea 在 三氟乙酸 作用下， 生成 1,4-二甲基-1,3-二氢-5-苯基-2H-咪唑-2-酮
  参考文献：
  名称：

  5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

  摘要：

  A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.064

文献信息

• Lithiation and electrophilic substitution of dimethyl triazones
  作者：Sunkyu Han、Dustin S. Siegel、Mohammad Movassaghi

  DOI：10.1016/j.tetlet.2012.04.121

  日期：2012.7

  The lithiation and electrophilic substitution of dimethyl triazones is described. Directed lithiation or tin–lithium exchange of dimethyl triazones afforded the corresponding dipole stabilized nucleophiles that were trapped with various electrophiles. Keto-triazone derivatives accessed by acylation of such nucleophiles were readily converted into the corresponding imidazolone heterocycles.

  描述了二甲基三嗪酮的锂化和亲电取代。二甲基三氮酮的定向锂化或锡-锂交换提供了相应的偶极稳定亲核试剂，这些亲核试剂被各种亲电子试剂捕获。通过此类亲核试剂的酰化获得的酮三酮衍生物很容易转化为相应的咪唑酮杂环。
• Butler, Anthony R.; Hussain, Ishtiaq, Journal of the Chemical Society. Perkin transactions II, 1981, p. 310 - 316
  作者：Butler, Anthony R.、Hussain, Ishtiaq

  DOI：——

  日期：——
• 5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity
  作者：Kazutoshi Watanabe、Yasuhiro Morinaka、Yoshio Hayashi、Masaki Shinoda、Hiroyoshi Nishi、Nobuko Fukushima、Toshiaki Watanabe、Akira Ishibashi、Satoshi Yuki、Masahiko Tanaka

  DOI：10.1016/j.bmcl.2007.12.064

  日期：2008.2

  A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation. (c) 2008 Elsevier Ltd. All rights reserved.