4-methyl-2-[(2E)-2-(6-methyl-2-phenyl-2,3-dihydrochromen-4-ylidene)hydrazinyl]-N-(3-nitrophenyl)-1,3-thiazole-5-carboxamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 4-methyl-2-[(2E)-2-(6-methyl-2-phenyl-2,3-dihydrochromen-4-ylidene)hydrazinyl]-N-(3-nitrophenyl)-1,3-thiazole-5-carboxamide
• 化学式: C27H23N5O4S
• 分子量: 513.6
• InChiKey: NDUFJNXLMGWOEZ-JBASAIQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  150
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• LINKED MYC-MAX SMALL MOLECULE INHIBITORS
  申请人：Metallo Steven J.

  公开号：US20120015989A1

  公开（公告）日：2012-01-19

  Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell.
• USE OF CYTOPLASMIC C-MYC FOR REGULATING IMMUNE RESPONSES
  申请人：LAU ALLAN SIK YIN

  公开号：US20120107317A1

  公开（公告）日：2012-05-03

  The subject invention provides novel uses of cytoplasmic c-Myc for modulation of innate immune responses. The invention is based, at least in part, on the surprising discovery that cytoplasmic c-Myc, instead of nuclear c-Myc, modulates pro-inflammatory immune responses via its role as a positive feedback regulator. Specifically, the subject invention provides methods for treatment or amelioration of inflammatory diseases and/or immune disorders via inhibition c-Myc expression or its activity. Also provided are methods for the development of therapeutic agents for treating infection, inflammation, immune diseases and autoimmune diseases.