1,6-二甲基-2(1H)-吡嗪酮 | 137232-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 1,6-二甲基-2(1H)-吡嗪酮
• 英文名称: 1,6-dimethyl-2(1H)-pyrazinone
• 英文别名: 1,6-dimethylpyrazin-2-one
• CAS: 137232-62-3
• 化学式: C₆H₈N₂O
• mdl: MFCD18811293
• 分子量: 124.142
• InChiKey: MVOFQFRALBXVIA-UHFFFAOYSA-N

物化性质

• 保留指数：
  1315

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  草酸醛 、 聚甘氨酸 生成 1,5-dimethylpyrazin-2-one 、 1,6-二甲基-2(1H)-吡嗪酮 、 1,5,6-trimethyl-2(1H)-pyrazinone
  参考文献：
  名称：

  Elucidation of the Mechanism of Pyrazinone Formation in Glycine Model Systems Using Labeled Sugars and Amino Acids

  摘要：

  Model studies using D-[C-13]glucoses and a series of C-2, C-3, and C-4 dicarbonyl compounds with labeled [N-15/C-13]glycines have indicated that methyl-substituted pyrazines and pyrazinones formed in these model systems have a common intermediate. The labeling studies have also helped to identify a new chemical transformation of alpha-dicarbonyls, affected by the amino acid, that lead to the addition of the C-2 atom of the amino acid to the alpha-dicarbonyl compounds, instead of the amino group as in the case of the Strecker-type interaction between the two reactants. Thus, glyoxal and pyruvaldehyde can be transformed into pyruvaldehyde and 2,3-butanedione, respectively, by the amino acid. Two pathways of formation of pyrazinones were distinguished on the basis of the labeling experiments, one involving the reaction of 3 mol of glycine and the other the interaction of the dipeptide glycylglycine with an alpha-dicarbonyl compound.

  DOI：

  10.1021/jf960067z

文献信息

• SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME
  申请人：BlinkBio, Inc.

  公开号：US20170202970A1

  公开（公告）日：2017-07-20

  Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.

  本文描述了基于硅的共轭物，能够将一个或多个有效载荷基团传递到靶细胞或组织。考虑到的共轭物可能包括一个硅-杂原子核心，一个或多个可选的催化基团，一个定位基团，允许共轭物在靶细胞或组织内积累，一个或多个有效载荷基团（例如，治疗剂或成像剂），以及与硅-杂原子核心共价结合的两个或更多个不干扰基团。
• Elucidation of the Mechanism of Pyrazinone Formation in Glycine Model Systems Using Labeled Sugars and Amino Acids
  作者：Anahita Keyhani、Varoujan A. Yaylayan

  DOI：10.1021/jf960067z

  日期：1996.1.1

  Model studies using D-[C-13]glucoses and a series of C-2, C-3, and C-4 dicarbonyl compounds with labeled [N-15/C-13]glycines have indicated that methyl-substituted pyrazines and pyrazinones formed in these model systems have a common intermediate. The labeling studies have also helped to identify a new chemical transformation of alpha-dicarbonyls, affected by the amino acid, that lead to the addition of the C-2 atom of the amino acid to the alpha-dicarbonyl compounds, instead of the amino group as in the case of the Strecker-type interaction between the two reactants. Thus, glyoxal and pyruvaldehyde can be transformed into pyruvaldehyde and 2,3-butanedione, respectively, by the amino acid. Two pathways of formation of pyrazinones were distinguished on the basis of the labeling experiments, one involving the reaction of 3 mol of glycine and the other the interaction of the dipeptide glycylglycine with an alpha-dicarbonyl compound.