1-(1-溴-2-甲基丙-1-烯基)-4-甲氧基苯 | 40811-05-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(1-溴-2-甲基丙-1-烯基)-4-甲氧基苯
• 英文名称: 1-Bromo-1-(4-methoxyphenyl)-2-methyl-1-propene
• 英文别名: Benzene, 1-(1-bromo-2-methyl-1-propenyl)-4-methoxy-；1-(1-bromo-2-methylprop-1-enyl)-4-methoxybenzene
• CAS: 40811-05-0
• 化学式: C₁₁H₁₃BrO
• 分子量: 241.128
• InChiKey: MBJKBYCBPJTPHQ-UHFFFAOYSA-N

物化性质

• 沸点：
  296.7±23.0 °C(Predicted)
• 密度：
  1.287±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(1-溴-2-甲基丙-1-烯基)-4-甲氧基苯 在 吡啶 、 silver hexafluoroantimonate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 生成 3-(4-Methoxyphenyl)-2,4-dimethyl-2,4-hexadien
  参考文献：
  名称：

  Harder, Ingo; Hanack, Michael, Chemische Berichte, 1985, vol. 118, # 7, p. 2974 - 2992

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(4-甲氧基苯基)-2-甲基丙烷-2-醇 在 硫酸 作用下， 生成 1-(1-溴-2-甲基丙-1-烯基)-4-甲氧基苯
  参考文献：
  名称：

  Rappoport,Z.; Gal,A., Journal of the Chemical Society. Perkin transactions II, 1973, p. 301 - 310

  摘要：

  DOI：

文献信息

• Why Are Vinyl Cations Sluggish Electrophiles?
  作者：Peter A. Byrne、Shinjiro Kobayashi、Ernst-Ulrich Würthwein、Johannes Ammer、Herbert Mayr

  DOI：10.1021/jacs.6b10889

  日期：2017.2.1

  slowly with trifluoroethanol than the parent benzhydrylium ion (Ph)2CH+, even though in solvolysis reactions (80% aqueous ethanol at 25 °C) the vinyl bromides leading to 2 and 3 ionize much more slowly (half-lives 1.15 yrs and 33 days) than (Ph)2CH-Br (half-life 23 s). The origin of this counterintuitive phenomenon was investigated by high-level MO calculations. We report that vinyl cations are not

  乙烯基阳离子 2 [Ph2C=C+-(4-MeO-C6H4)] 和 3 [Me2C=C+-(4-MeO-C6H4)]（由激光闪光光解产生）与多种亲核试剂（例如、吡咯、卤化物离子和含有不同量水或醇的溶剂）已通过光度法测定。发现亲核试剂对这些乙烯基阳离子的反应顺序与对二芳基碳鎓离子（二苯甲基鎓离子）的反应顺序相同。然而，乙烯基阳离子的反应速率受亲核试剂变化的影响仅是二苯甲基离子的反应速率的一半。因此，乙烯基阳离子和二苯甲基离子的相对反应性在很大程度上取决于亲核试剂的性质。结果表明，乙烯基阳离子 2 和 3 分别反应，使用三氟乙醇比母体二苯鎓离子 (Ph)2CH+ 慢 227 和 14 倍，即使在溶剂分解反应（25°C 时为 80% 乙醇水溶液）中，导致 2 和 3 的乙烯基溴离子化得更慢（半衰期 1.15年和 33 天）比 (Ph)2CH-Br（半衰期 23 秒）。通过高级 MO 计算研究了这
• Lifetimes and UV-visible absorption spectra of benzyl, phenethyl, and cumyl carbocations and corresponding vinyl cations. A laser flash photolysis study
  作者：Frances L Cozens、V M Kanagasabapathy、Robert A McClelland、Steen Steenken

  DOI：10.1139/v99-210

  日期：1999.12.5

  Benzyl (4-MeO, 4-Me, and 4-methoxy-1-naphthylmethyl), phenethyl (4-Me₂N, 4-MeO, 3,4-(MeO)₂, 4-Me, 3-Me, 4-F, 3-MeO, 2,6-Me₂, parent, and 4-methoxy-1-naphthylethyl) and cumyl (4-Me₂N, 4-MeO, 4-Me, parent) cations have been studied by laser flash photolysis (LFP) in 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP). In most cases styrene or α-methylstyrene precursors were employed for the phenethyl and cumyl ions, the intermediate being obtained by solvent protonation of the excited state. Benzyl cations were generated by photoheterolysis of trimethylammonium and chloride precursors. While a 4-MeO substituent provides sufficient stabilization to permit observation of cations in TFE, cations with less stabilizing substituents usually require the less nucleophilic HFIP. Even in this solvent, the parent benzyl cation is too short-lived (lifetime <20 ns) to be observed. When generated in HFIP, phenethyl cations can be seen to react with unphotolyzed styrene, giving rise to dimer cations that are observed to grow in as the initial phenethyl cation decays. The dimer cations, in common with the oligomer cations seen in cationic styrene polymerization, have a λ_max 15-20 nm higher than the monomer and react with both solvent and styrene several orders of magnitude more slowly. This stabilization relative to the phenethyl may reflect an interaction with the aryl group present at the gamma-carbon. Cations 4-MeOC₆H₄C⁺(R)-CH₃ (R = Me, Et, i-Pr, t-Bu, cyclopropyl, C₆H₅, 4-MeOC₆H₄) were generated in TFE via the photoprotonation route. The alkyl series shows that steric effects are important in the decay reaction. The cation with R = cyclopropyl is a factor of 1.5 less reactive than the cation where R = phenyl. Several vinyl cations have also been generated by photoprotonation of phenylacetylenes. ArC⁺=CH₂ has a reactivity very similar to that of its analog ArC⁺H-CH₃, the vinyl cation being slightly (factors of 2-5) shorter-lived. For the various series of cations, including vinyl, substituents in the aryl ring have a consistent effect on the λ_max, a shift to higher wavelength relative to hydrogen of 15 nm for 4-Me, 30 nm for 4-MeO, and 50 nm for 4-Me₂N.Key words: photogenerated carbocations, carbocation lifetime, styrene, photoprotonation.

  苯甲基（4-MeO，4-Me和4-甲氧基-1-萘基甲基）、苯乙基（4-Me2N，4-MeO，3,4-(MeO)2，4-Me，3-Me，4-F，3-MeO，2,6-Me2，母体和4-甲氧基-1-萘基乙基）和叔丁基（4-Me2N，4-MeO，4-Me，母体）阳离子在2,2,2-三氟乙醇（TFE）和1,1,1,3,3,3-六氟异丙醇（HFIP）中通过激光闪光光解（LFP）进行了研究。在大多数情况下，苯乙烯或α-甲基苯乙烯前体被用于苯乙基和叔丁基离子，中间体通过溶剂质子化激发态而获得。苯甲基阳离子是通过三甲基铵和氯化物前体的光异裂生成的。虽然4-MeO取代基提供了足够的稳定性以在TFE中观察到阳离子，但具有较少稳定取代基的阳离子通常需要较不亲核的HFIP。即使在这种溶剂中，母体苯甲基阳离子也太短寿命（寿命<20 ns）而无法观察到。在HFIP中生成的苯乙基阳离子可以看到与未经光解的苯乙烯反应，导致观察到的二聚体阳离子在初始苯乙基阳离子衰减时增长。与阳离子苯乙烯聚合中观察到的寡聚体阳离子一样，二聚体阳离子的λmax比单体高15-20 nm，并且与溶剂和苯乙烯反应速度慢几个数量级。相对于苯乙基的这种稳定性可能反映了与伽马碳上存在的芳基的相互作用。在TFE中通过光质子化途径生成了4-MeOC6H4C+(R)-CH3（R = Me，Et，i-Pr，t-Bu，环丙基，C6H5，4-MeOC6H4）阳离子。烷基系列表明立体效应在衰减反应中很重要。当R = 环丙基时，其反应性比R = 苯基的阳离子少1.5倍。还通过对苯乙炔的光质子化生成了几种乙烯阳离子。ArC+=CH2的反应性与其类似物ArC+H-CH3非常相似，乙烯阳离子寿命略短（2-5倍因子）。对于包括乙烯在内的各系列阳离子，芳香环中的取代基对λmax有一致的影响，相对于氢的15 nm的4-Me，30 nm的4-MeO和50 nm的4-Me2N的波长偏移。关键词：光产生的碳正离子，碳正离子寿命，苯乙烯，光质子化。
• REACTION OF PHOTOGENERATED VINYL CATIONS WITH AMBIDENT ANIONS
  作者：Tsugio Kitamura、Shinjiro Kobayashi、Hiroshi Taniguchi

  DOI：10.1246/cl.1984.1523

  日期：1984.9.5

  Photolysis of vinyl bromides with cyanate anion In a two-phase system gave only isoquinolinones as the N-site attacked products. However, the photolysis with thiocyanate anion gave both the N-site attacked products, isothioquinolinones or vinyl isothiocyanates, and the S-site attacked products, vinyl thiocyanates.

  乙烯基溴与氰酸根阴离子的光解在两相系统中仅产生异喹啉酮作为 N 位攻击产物。然而，用硫氰酸根阴离子光解得到 N 位攻击产物，异硫喹啉酮或乙烯基异硫氰酸酯，和 S 位攻击产物，乙烯基硫氰酸酯。
• Reaction of tricarbonyl[(1-4-η)-2-methoxy-5-vinylidene-cyclohexa-1,3-diene]iron derivatives with carbene: (2+1) cycloaddition for the rapid synthesis of spiro[2,5]octane
  作者：Jeng Liang Han、Chi Wi Ong

  DOI：10.1016/j.tet.2004.11.081

  日期：2005.2

  complexes are unstable 4-vinylidene cyclohexanone equivalents and these react regio- and stereoselectively with carbenes and metallocarbenes to give spiro[2,5]octane ring system. The (2+1) cycloaddition reaction provides a rapid entry into spiro[2,5]octane ring system. In cases where the carbene and metallocarbene contain a good bulky leaving group or an electron-withdrawing group, the cyclopropane ring-opening

  三羰基[（1-4-η）-2-甲氧基-5-亚甲基-环己-1,3-二烯]铁（1a）和三羰基[（1-4-η）-2-甲氧基-5-异丙烯-环丙烯-1,3-二烯]铁（1b）配合物是不稳定的4-亚乙烯基环己酮当量，它们与碳烯和金属碳烯进行区域和立体选择性反应，生成螺[2,5]辛烷环系统。（2 + 1）环加成反应可快速进入螺[2,5]辛烷环系统。在卡宾和金属卡宾具有良好的蓬松离去基团或吸电子基团的情况下，获得了环丙烷开环产物。
• Photochromic Performance of 1-Thiazolyl-2-vinylcyclopentene Derivatives Having a Phenyl- or 4-Methoxyphenyl-Substituted Olefin
  作者：Shizuka Takami、Ayano Shimizu、Kazuyuki Shimizu、Ryota Miyoshi、Tadatsugu Yamaguchi、Masahiro Irie

  DOI：10.1246/bcsj.20130091

  日期：2013.9.15

  1-Thiazolyl-2-vinylcyclopentene derivatives, 1-(5-methoxy-2-phenyl-4-thiazolyl)-2-(2-methyl-1-phenyl-1-propenyl)perfluorocyclopentene (1a), 1-[5-methoxy-2-(4-methoxyphenyl)-4-thiazolyl]-2-(2-methyl-1-phenyl-1-propenyl)perfluorocyclopentene (2a), and 1-[5-methoxy-2-(4-methoxyphenyl)-4-thiazolyl]-2-[1-(4-methoxyphenyl)-2-methyl-1-propenyl]perfluorocyclopentene (3a) were synthesized in an attempt to obtain yellow photochromic compounds having low photocycloreversion quantum yields and large absorption coefficients of the closed-ring isomers. Their photochromic performance, thermal stability, and fatigue resistance were compared with 1-[5-methoxy-2-(4-methoxyphenyl)-4-thiazolyl]-2-(1,2-dimethyl-1-propenyl)perfluorocyclopentene (4a) having a methyl-substituted olefin. Upon irradiation with 313 nm light, compounds 1a, 2a, and 3a changed from colorless to various shades of yellow in toluene. The conversions from the open-ring (1a, 2a, and 3a) to the closed-ring (1b, 2b, and 3b) isomers in the photostationary state under irradiation with 313 nm light were 93, 95, and 98%, respectively. Among the three derivatives 3b has the largest absorption coefficient (ε = 18900 M−1 cm−1) at 428 nm and the lowest cycloreversion quantum yield of 1.8 × 10−3.

  1-噻唑基-2-乙烯基环戊烯衍生物，1-(5-甲氧基-2-苯基-4-噻唑基)-2-(2-甲基-1-苯基-1-丙烯基)全氟环戊烯(1a)，1-[5-甲氧基-2-(4-甲氧基苯基)-4-噻唑基]-2-(2-甲基-1-苯基-1-丙烯基)全氟环戊烯(2a)、和 1-[5-甲氧基-2-(4-甲氧基苯基)-4-噻唑基]-2-[1-(4-甲氧基苯基)-2-甲基-1-丙烯基]全氟环戊烯 (3a)的合成，试图获得具有较低光环转化量子产率和较大闭环异构体吸收系数的黄色光致变色化合物。将它们的光致变色性能、热稳定性和抗疲劳性与具有甲基取代烯烃的 1-[5-甲氧基-2-（4-甲氧基苯基）-4-噻唑基]-2-（1,2-二甲基-1-丙烯基）全氟环戊烯（4a）进行了比较。经 313 纳米光照射后，化合物 1a、2a 和 3a 在甲苯中由无色变为深浅不一的黄色。在 313 纳米光照射下，开环异构体（1a、2a 和 3a）向光静止态闭环异构体（1b、2b 和 3b）的转化率分别为 93%、95% 和 98%。在这三种衍生物中，3b 在 428 纳米波长处的吸收系数最大（ε = 18900 M-1 cm-1），环化量子产率最低，为 1.8 × 10-3。