1-(2-氯苯基)-1-戊醇 | 22869-36-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2-氯苯基)-1-戊醇
• 英文名称: 1-(2-Chlorophenyl)pentan-1-ol
• CAS: 22869-36-9
• 化学式: C₁₁H₁₅ClO
• 分子量: 198.692
• InChiKey: GKJCFLAJULLNGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  n-Bu3MgLi 、 邻氯苯甲酰氯 在 manganese(II) chloride tetrahydrate 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 1-(2-氯苯基)-1-戊醇 、 1-(2-chlorophenyl)-pentan-1-one 、 1-(2-丁基苯基)戊-1-酮
  参考文献：
  名称：

  邻卤代苯甲酰氯与二有机基镁化合物的高效MnCl2催化串联酰化-交叉偶联反应

  摘要：

  开发了在氯化锰（II）存在下邻氯苯甲酰氯与二烷基和二芳基镁化合物的高效串联交叉偶联反应，该反应在温和条件下以良好的收率进行。版权所有©2009 John Wiley＆Sons，Ltd.

  DOI：

  10.1002/aoc.1567

文献信息

• Biaryl Acyl-Sulfonamide Compounds as Sodium Channel Inhibitors
  申请人：AMEGEN INC.

  公开号：US20160214971A1

  公开（公告）日：2016-07-28

  The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of voltage-gated sodium channels, in particular Nav 1.7. as described in the specification. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention, as well as intermediates and processes useful for making the compounds.

  本发明提供了公式（Ia）的化合物及其药学上可接受的盐。这些化合物可用作电压门控钠通道的抑制剂，特别是Nav 1.7，如规范中所述。这些化合物可用于治疗可通过抑制钠通道治疗的疾病，例如疼痛障碍。还提供了含有本发明化合物的制药组合物，以及制造这些化合物的中间体和工艺。
• Method for producing an aromatic compound having an alkyl group with at least three carbon atoms
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0985649A2

  公开（公告）日：2000-03-15

  Aromatic compounds having an alkyl group with at least 3 carbon atoms are produced in a process comprising at least one of the following steps: (1) a step of contacting a starting material that contains an aromatic compound having a branched alkyl group with at least 3 carbon atoms, with a zeolite-containing catalyst in a liquid phase in the presence of hydrogen therein, thereby changing the position of the carbon atoms of the alkyl group bonding to the aromatic ring of the compound; (2) a step of contacting a starting material that contains an aromatic compound having a branched alkyl group with at least 3 carbon atoms, with a catalyst containing zeolite and containing rhenium and/or silver, in a liquid phase, thereby changing the position of the carbon atoms of the alkyl group bonding to the aromatic ring of the compound; (3) a step of contacting a halogenated aromatic compound having an alkyl group with at least 3 carbon atoms, with an acid-type catalyst, thereby isomerizing the compound; and (4) a step of treating a mixture of isomers of an aromatic compound having an alkyl group with at least 3 carbon atoms, with a zeolite adsorbent that contains at least one exchangable cation selected from alkali metals, alkaline earth metals, lead, thallium and silver, thereby separating a specific isomer from the isomer mixture through adsorption.

  具有至少 3 个碳原子烷基的芳香族化合物的生产工艺至少包括以下一个步骤： (1) 将含有至少 3 个碳原子的支链烷基的芳香族化合物的起始原料在液相中与含沸石的催化剂在氢存在的情况下接触，从而改变烷基的碳原子与化合物的芳香环键合的位置； (2) 将含有芳香族化合物的起始原料与含沸石和含铼和/或银的催化剂在液相中接触，该芳香族化合物具有至少 3 个碳原子的支链烷基，从而改变烷基碳原子与化合物芳香环键合的位置； (3) 将具有至少 3 个碳原子的烷基的卤代芳香族化合物与酸型催化剂接触，从而使该化合物异构化；以及 (4) 用沸石吸附剂处理具有至少 3 个碳原子的烷基的芳香族化合物的异构体混合物，该沸石吸附剂含有至少一种选自碱金属、碱土金属、铅、铊和银的可交换阳离子，从而通过吸附从异构体混合物中分离出特定的异构体。
• US6462248B1
  申请人：——

  公开号：US6462248B1

  公开（公告）日：2002-10-08
• US9663508B2
  申请人：——

  公开号：US9663508B2

  公开（公告）日：2017-05-30
• An efficient MnCl₂-catalyzed tandem acylation-cross-coupling reaction of<i>o</i>-halobenzoyl chloride with diorganyl magnesium compounds
  作者：Fengmin Zhang、Zhuangzhi Shi、Feng Chen、Yu Yuan

  DOI：10.1002/aoc.1567

  日期：——

  An efficient tandem cross‐coupling reaction of o‐chlorobenzoyl chloride with dialkyl and diaryl magnesium compounds in the presence of manganese (II) chloride was developed, which proceeds in good yield under mild conditions. Copyright © 2009 John Wiley & Sons, Ltd.

  开发了在氯化锰（II）存在下邻氯苯甲酰氯与二烷基和二芳基镁化合物的高效串联交叉偶联反应，该反应在温和条件下以良好的收率进行。版权所有©2009 John Wiley＆Sons，Ltd.