1-(3,6-二氢-2H-吡喃-4-基)乙酮 | 405910-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 中文名称: 1-(3,6-二氢-2H-吡喃-4-基)乙酮
• 英文名称: 1-(3,6-Dihydro-2H-pyran-4-yl)-ethanone
• 英文别名: 1-(3,6-Dihydro-2H-pyran-4-yl)ethan-1-one；1-(3,6-dihydro-2H-pyran-4-yl)ethanone
• CAS: 405910-68-1
• 化学式: C₇H₁₀O₂
• 分子量: 126.155
• InChiKey: KDWKXQAAHXFYFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4-Allyloxy-but-1-ynyloxy)-triisopropyl-silane 在 [(N,N-(MeSO₂)2-imidazolidin-2-yl)RuCl₂(PCy₃)=CHPh] 、 氢氟酸 作用下， 以 苯 、 乙腈 为溶剂， 反应 1.5h， 以88%的产率得到1-(3,6-二氢-2H-吡喃-4-基)乙酮
  参考文献：
  名称：

  Siloxyalkyne–Alkene Metathesis: Rapid Access to Highly Functionalized Enones

  摘要：

  Mechanistically intriguing participation of siloxyalkynes occurs in the intramolecular Ru-catalyzed metathesis with terminal alkenes (see scheme; Ms=methanesulfonyl). Combined with efficient protodesilylation, this process resulted in the development of a new method for the synthesis of highly functionalized enones starting from readily accessible acyclic precursors. Heterocyclic and polycyclic compounds were prepared efficiently, which illustrates the generality of this novel method.

  DOI：

  10.1002/1521-3773(20011119)40:22<4274::aid-anie4274>3.0.co;2-#

文献信息

• THIAZOLE DERIVATIVES
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：EP3002283B1

  公开（公告）日：2017-06-14
• Siloxyalkyne–Alkene Metathesis: Rapid Access to Highly Functionalized Enones
  作者：Michael P. Schramm、D. Srinivasa Reddy、Sergey A. Kozmin

  DOI：10.1002/1521-3773(20011119)40:22<4274::aid-anie4274>3.0.co;2-#

  日期：2001.11.19

  Mechanistically intriguing participation of siloxyalkynes occurs in the intramolecular Ru-catalyzed metathesis with terminal alkenes (see scheme; Ms=methanesulfonyl). Combined with efficient protodesilylation, this process resulted in the development of a new method for the synthesis of highly functionalized enones starting from readily accessible acyclic precursors. Heterocyclic and polycyclic compounds were prepared efficiently, which illustrates the generality of this novel method.