1-(3-丁烯-1-基)-4-乙氧基苯 | 344408-46-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(3-丁烯-1-基)-4-乙氧基苯
• 英文名称: 4-(4-Ethoxyphenyl)-1-butene
• 英文别名: 1-but-3-enyl-4-ethoxybenzene
• CAS: 344408-46-4
• 化学式: C₁₂H₁₆O
• mdl: MFCD09801135
• 分子量: 176.258
• InChiKey: GINJIHQQNISPQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  246.4±9.0 °C(Predicted)
• 密度：
  0.923±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909309090

反应信息

• 作为产物：
  描述：

  1,3-丁二烯 、 magnesium,ethoxybenzene,bromide 、 三氯化铁 生成 1-(3-丁烯-1-基)-4-乙氧基苯
  参考文献：
  名称：

  ZUBRITSKIJ, L. M.;ROMASHCHENKOVA, N. D.;PETROV, A. A., ZH. ORGAN. XIMII, 1983, 19, N 12, 2465-2477

  摘要：

  DOI：

文献信息

• Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0637580A1

  公开（公告）日：1995-02-08

  A 1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent. The phenylalkene derivative is prepared by reacting an alkenyl halide with metal magnesium to form a Grignard reagent, and then reacting the Grignard reagent with a benzyl halide derivative. An allyl Grignard reagent is prepared by reacting continuously an allyl halide derivative with metal magnesium in an organic solvent, in which the allyl halide derivative and metal magnesium are continuously added to the reaction system and the allyl Grignard reagent formed is continuously removed from the reaction system. The processes provide the intended compounds in high yields, high selectivities and high purities.

  1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent.苯基烷烃衍生物的制备方法是先使烯基卤化物与金属镁反应生成格氏试剂，然后使格氏试剂与苄基卤化物衍生物反应。烯丙基格氏试剂是通过烯丙基卤化物衍生物与金属镁在有机溶剂中连续反应制备的，其中烯丙基卤化物衍生物和金属镁被连续加入反应体系，形成的烯丙基格氏试剂被连续从反应体系中移除。这些工艺可提供高产率、高选择性和高纯度的预期化合物。
• PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USES THEREOF
  申请人：Tianjin Institute Of Pharmaceutical Research

  公开号：EP3246324A2

  公开（公告）日：2017-11-22

  The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.

  本发明提供了一种由式I表示的含有脱氧葡萄糖结构的苯基C-葡萄糖苷衍生物、其制备方法、包含其的药物组合物以及其在制备治疗糖尿病药物中的用途，其中取代基R1-R7如说明书中所定义。本发明还提供了一种合成含有脱氧葡萄糖结构的苯基 C-葡萄糖苷衍生物和中间产物的方法。该方法具有操作简单、成本低的优点，适合大规模工业化生产。本发明进一步提供了一种(1S)-1-[4-氯-3-(4-乙氧基苄基)苯基]-1,6-二脱氧-D-葡萄糖和 L-脯氨酸的共晶体及其制备方法和用途。
• Zubritskii, L. M.; Romashchenkova, N. D.; Petrov, A. A., Journal of Organic Chemistry USSR (English Translation), 1983, p. 2157 - 2167
  作者：Zubritskii, L. M.、Romashchenkova, N. D.、Petrov, A. A.

  DOI：——

  日期：——
• 1,3-Dioxolane derivatives as cholesterol-lowering agents
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0492474B1

  公开（公告）日：1997-03-05
• Process for producing epoxides
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0540009B1

  公开（公告）日：1995-08-30