Methyl 2-(4-chlorophenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Methyl 2-(4-chlorophenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylate
• 英文别名: methyl 2-(4-chlorophenyl)imidazo[2,1-b][1,3]benzothiazole-6-carboxylate
• 化学式: C₁₇H₁₁ClN₂O₂S
• mdl: MFCD14798137
• 分子量: 342.8
• InChiKey: YZNUYORNNCXCAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  71.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• ENDOPLASMIC RETICULUM STRESS REGULATOR COMPRISING BENZOTHIAZOIMIDAZOLYL COMPOUND
  申请人：ER Stress Research Institute, Inc.

  公开号：US20210386715A1

  公开（公告）日：2021-12-16

  A compound of general formula (1) [wherein: R 1 and R 2 , which are the same or different, each represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower cycloalkyl group, a lower alkanoyl group, a halogen substituted lower alkyl group, a lower alkoxy group, a halogen substituted lower alkoxy group, a cyano group, a cross-linked methylenedioxy group, an ethylenedioxy group, a propylenedioxy group, a lower alkylthio group, a lower alkylsulfonyl group, a carboxyl group, a lower alkoxycarbonyl group, a lower alkylamide group, a lower alkylamino alkylene amide group, an amino group, an alkylamino group, a hydroxy group, a functional group represented by general formula (2), or a functional group represented by general formula (3) —CONH(CH 2 ) p —R 3 ( 2 ) [wherein R 3 represents a di-lower alkylamino group, a morpholino group, a piperidino group, a 2-methyl-piperidino group, or a 2-oxo-pyrrolidinyl group; p represents an integer from 2 to 6]; [wherein, R 4 represents a lower alkyl group]; m and n each represent an integer from 0 to 3; the term lower represents a carbon number of 1 to 6; and the halogen atom represents a fluorine, chlorine or bromine atom] can inhibit endoplasmic reticulum stress to a greater extent as compared to known chemical chaperones. The compound thus can be used suitably as an agent for preventing, ameliorating or treating various diseases that are caused by endoplasmid reticulum stress.