4-(5-chloro-3-phenyl-1H-indazol-1-yl)-N-(4-fluorophenyl)butanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(5-chloro-3-phenyl-1H-indazol-1-yl)-N-(4-fluorophenyl)butanamide
• 英文别名: 4-(5-chloro-3-phenylindazol-1-yl)-N-(4-fluorophenyl)butanamide
• 化学式: C₂₃H₁₉ClFN₃O
• 分子量: 407.9
• InChiKey: CMCIHVQNGJPJTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR POTENTIATING ANTIBIOTIC ACTIVITY
  申请人：Cottarel Guillaume

  公开号：US20100234348A1

  公开（公告）日：2010-09-16

  The present invention provides compounds that potentiate the activity of antibiotic agents, particularly quinolones such as norflaxin. The invention further provides compositions, e.g., pharmaceutical compositions, comprising the inventive compounds. The invention also provides compositions comprising an antibiotic (e.g., a quinolone) and a compound that potentiates activity of the antibiotic. The invention further provides methods of treating a subject comprising administering any of the inventive compounds or compositions to the subject. The invention also provides screening methods to identify compounds that potentiate the activity of an antibiotic, e.g., a quinolone.