1-(4-乙氧苯基)-3-乙硫基脲 | 15863-23-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-乙氧苯基)-3-乙硫基脲
• 英文名称: 1-(4-ethoxyphenyl)-3-ethylthiourea
• 英文别名: N-(4-ethoxy-phenyl)-N'-ethyl-thiourea；N-(4-Aethoxy-phenyl)-N'-aethyl-thioharnstoff；N-ethyl-N'-[4-(ethyloxy)phenyl]thiourea；N-Et-N'-(4-EtO-Phenyl)thiocarbamid
• CAS: 15863-23-7
• 化学式: C₁₁H₁₆N₂OS
• mdl: MFCD00022137
• 分子量: 224.327
• InChiKey: IZIKORVGYQJQMK-UHFFFAOYSA-N

物化性质

• 熔点：
  112 °C
• 沸点：
  323.6±44.0 °C(Predicted)
• 密度：
  1.143±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  65.4
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  1-(4-乙氧苯基)-3-乙硫基脲 在 ammonium hydroxide 、 selenium 作用下， 以 乙醇 、 丙酮 为溶剂， 生成 1-(4-Ethoxy-phenyl)-3-ethyl-selenourea
  参考文献：
  名称：

  A Convenient Synthesis of Mono-,N,N′-Di-, and Trisubstituted Selenoureas from Methyl Carbamimidothioates (S-Methylpseudothioureas)

  摘要：

  DOI：

  10.1055/s-1980-28927
• 作为产物：
  描述：

  乙胺 、 4-乙氧基苯基硫氰酸酯 生成 1-(4-乙氧苯基)-3-乙硫基脲
  参考文献：
  名称：

  Some Alkyl Derivatives of Certain Aryl Substituted Thiazolidones¹

  摘要：

  DOI：

  10.1021/ja01315a093

文献信息

• Synthesis of phenylisothiourea derivatives as inhibitors of NO production in LPS activated macrophages
  作者：Guo Hua Jin、Da Yeon Lee、Ye-Jin Cheon、Hyo Jin Gim、Do Hee Kim、Hee-Doo Kim、Jae-Ha Ryu、Raok Jeon

  DOI：10.1016/j.bmcl.2009.04.001

  日期：2009.6

  A series of phenylisothioureas were synthesized as inhibitors of NO production in lipopolysaccharide-activated macrophages. We investigated the effect of lipophilic moiety and N- or S-substituents of the phenylisothioureas on the activity. Inhibitory activities of carbazole-linked phenylisothioureas were superior to the corresponding simple phenylisothiourea derivatives. Among these compounds, 12b having N- ethyl and S-isopropyl groups on phenylisothiourea moiety was the most potent in the inhibition of NO production. They inhibited NO production through the suppression of the LPS-induced translocation of p65 subunit of NF-kappa B and the followed suppression of the iNOS protein and mRNA expression. (C) 2009 Elsevier Ltd. All rights reserved.
• WO2007/122241
  申请人：——

  公开号：——

  公开（公告）日：——
• Two-component initiator system (amine-free) with very good storage stability and particular suitability for acid systems
  申请人：Utterodt Andreas

  公开号：US20070040151A1

  公开（公告）日：2007-02-22

  A two-component initiator system having accelerators for curing polymerizable materials comprising the following components: (a) a hydroperoxide compound containing one or more hydroperoxide groups that are bound to a tertiary carbon; (b) a thiourea derivative; and (c) as accelerator, a copper compound which is soluble in the preparation is preferably free of amine and is particularly suited for polymerizable dental compositions.
• [EN] COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE<br/>[FR] COMPOSÉS INDUISANT LA POTENTIALISATION DU RÉCEPTEUR AMPA ET LEURS APPLICATIONS EN MÉDECINE
  申请人：GLAXO GROUP LTD

  公开号：WO2007122241A1

  公开（公告）日：2007-11-01

  [EN] Compounds of formula (I), and salts and solvates thereof for use as a medicament are provided: (I) wherein R¹, R², R⁴, R¹⁰, X and Z are defined in the specification. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.
  [FR] La présente invention concerne des composés de formule (I), ainsi que des sels et des solvates desdits composés, pour une utilisation en tant que médicament : (I) où R¹, R², R⁴, R¹⁰, X et Z sont tels que définis dans la description de l'invention. La présente invention a également pour objet des procédés de synthèse, des compositions pharmaceutiques et leurs applications en tant que médicament, par exemple dans le traitement d'une maladie ou d'un état pathologique faisant intervenir une réduction ou un déséquilibre du fonctionnement du récepteur de glutamate, tel que la schizophrénie ou les déficits cognitifs.
• A Convenient Synthesis of Mono-,<i>N</i>,<i>N</i>′-Di-, and Trisubstituted Selenoureas from Methyl Carbamimidothioates (<i>S</i>-Methylpseudothioureas)
  作者：Victor Israel Cohen

  DOI：10.1055/s-1980-28927

  日期：——