柠康酸甘氨酸酰亚胺 | 10490-20-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 柠康酸甘氨酸酰亚胺
• 英文名称: citraconic acid glycine imide
• 英文别名: 2-(3-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid；Citraconylglycin；N-Carboxymethyl-citraconimid；N,N-methylmaleoyl-glycine；2-(3-methyl-2,5-dioxopyrrol-1-yl)acetic acid
• CAS: 10490-20-7
• 化学式: C₇H₇NO₄
• mdl: MFCD11643032
• 分子量: 169.137
• InChiKey: GAOKXSIWDUODDM-UHFFFAOYSA-N

物化性质

• 熔点：
  127-128 °C
• 沸点：
  368.1±25.0 °C(Predicted)
• 密度：
  1.454±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  柠康酸甘氨酸酰亚胺 在 氢氧化钾 作用下， 生成 N-Carboxymethyl-citraconamidsaeure
  参考文献：
  名称：

  Formation and stability of amide and imide links

  摘要：

  DOI：

  10.1007/bf00845946
• 作为产物：
  描述：

  柠康酸酐 、 聚甘氨酸 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 5.0h， 生成 柠康酸甘氨酸酰亚胺
  参考文献：
  名称：

  [EN] POLYFUNCTIONAL HYDROPHTHALIMIDE MONOMER COMPOUNDS
  [FR] COMPOSÉS MONOMÈRES D'HYDROPHTHALIMIDE POLYFONCTIONNELS

  摘要：

  本发明涉及一种酰亚胺化合物，根据以下任一式Ia、Ib、Ic或Ie，其中R1为H或C1-C20的可选取代的碳氢基团；R2和R5均为COOH基团，或者R2和R5中的一个是COOH基团，而另一个取代基为H、甲基或乙基基团；R3和R4独立地为H，或C1-C20的可选取代的碳氢基团；R6为H或甲基基团；R7和R8独立地为H、甲基或乙基。

  公开号：

  WO2016097403A1

文献信息

• METHODS AND REAGENTS FOR ANALYZING PROTEIN-PROTEIN INTERFACES
  申请人：Revolution Medicines, Inc.

  公开号：US20210285955A1

  公开（公告）日：2021-09-16

  The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins.

  本公开提供了用于分析蛋白质-蛋白质界面的方法和试剂，例如展示蛋白质（例如FKBP家族成员、环肽酶家族成员或PIN1）与靶蛋白质之间的界面。在某些实施例中，靶蛋白质和/或展示蛋白质是细胞内蛋白质。在某些实施例中，靶蛋白质和/或展示蛋白质是哺乳动物蛋白质。
• Citraconimide (co)polymers and curing with anionic catalyst
  申请人：Akzo Nobel N.V.

  公开号：EP0495545A1

  公开（公告）日：1992-07-22

  A process for the preparation of a (co)polymer containing at least one unit derived from a citraconimide by curing curable composition comprising at least one substituted or unsubstituted citraconimide and a sufficient amount of an anionic curing catalyst to convert at least 10% of the citraconic alkyl groups on the citraconimide units to alkylene bridges; at a temperature above the melting point of the citraconimide unit and the product of that curing process, are disclosed. The invention also relates to the cured oligomers and articles of manufacture embodying them. These novel, cured oligomers are thermoplastic and offer several advantageous properties.

  本发明公开了一种制备含有至少一个源自柠康亚胺的单元的（共）聚合物的工艺，其方法是在高于柠康亚胺单元熔点的温度下，固化可固化组合物，该组合物包括至少一个取代或未取代的柠康亚胺和足量的阴离子固化催化剂，以将柠康亚胺单元上至少 10%的柠康烷基转化为亚烷基桥。本发明还涉及固化后的低聚物及其制造品。这些新型固化低聚物是热塑性的，具有多种优势特性。
• PROCESS FOR THE MODIFICATION OF POLYPHENYLENE ETHER RESIN COMPOSITIONS
  申请人：Akzo Nobel N.V.

  公开号：EP0648240A1

  公开（公告）日：1995-04-19
• COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF
  申请人：Revolution Medicines, Inc.

  公开号：US20200199102A1

  公开（公告）日：2020-06-25

  The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein (e.g., a eukaryotic target protein such as a mammalian target protein or a fungal target protein or a prokaryotic target protein such as a bacterial target protein). These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of intracellular target proteins. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of the targeted protein's activity.
• US5221717A
  申请人：——

  公开号：US5221717A

  公开（公告）日：1993-06-22