1-(4-甲氧基苯基)-3-(对甲苯基)脲 | 56103-85-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 中文名称: 1-(4-甲氧基苯基)-3-(对甲苯基)脲
• 英文名称: 2,2,3-trichloropropionyl chloride
• 英文别名: 2,2,3-trichloropropanoyl chloride；trichloropropanoyl chloride；2,2,3-trichloro-propionyl chloride；2,2,3-Trichlor-propionylchlorid；2,2,3-Trichlorpropionylchlorid
• CAS: 56103-85-6
• 化学式: C₃H₂Cl₄O
• 分子量: 195.86
• InChiKey: MIVJCGCWXLNSNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-甲氧基苯基)-3-(对甲苯基)脲 生成 2,3-dichloro-acryloyl chloride
  参考文献：
  名称：

  Pyrolysis

  摘要：

  公开号：

  US02351346A1
• 作为产物：
  描述：

  2,2,3-三氯丙酸 在 二氯化二硫 、 氯 、 zinc(II) chloride 作用下， 生成 1-(4-甲氧基苯基)-3-(对甲苯基)脲
  参考文献：
  名称：

  Pyrolysis

  摘要：

  公开号：

  US02351346A1

文献信息

• N-aryl-azetidinones, their preparation process and their use as elastase
  申请人：Scientifique

  公开号：US05030628A1

  公开（公告）日：1991-07-09

  The invention relates to N-aryl-azetidinones, their preparation process and their use as active serine elastase inhibitors. The N-aryl-azetidinones are in accordance with formula: ##STR1## in which R.sup.1 and R.sup.2 can be a halogen atom or an organic radical, R.sup.3 represents a halogen atom or another good starting group and R.sup.4 represents H or an organic radical. The compounds with R.sup.3 .dbd.Cl or OSO.sub.2 CH.sub.3, R.sup.4 .dbd.H and R.sup.1 .dbd.R.sup.2 .dbd.F or R.sup.1 .dbd.F and R.sup.2 .dbd.Br are irreversible and selective elastase inhibitors.

  该发明涉及N-芳基-氮杂环丙酮酸酯，其制备过程以及它们作为活性丝氨酸弹性蛋白酶抑制剂的用途。N-芳基-氮杂环丙酮酸酯符合以下结构式：##STR1## 其中R.sup.1和R.sup.2可以是卤素原子或有机基团，R.sup.3代表卤素原子或另一个良好的起始基团，R.sup.4代表H或有机基团。具有R.sup.3 .dbd.Cl或OSO.sub.2 CH.sub.3，R.sup.4 .dbd.H和R.sup.1 .dbd.R.sup.2 .dbd.F或R.sup.1 .dbd.F和R.sup.2 .dbd.Br的化合物是不可逆和选择性的弹性蛋白酶抑制剂。
• PROCESS FOR PREPARING ACYL AMIDE COMPOUNDS
  申请人：BOLL MATTHIAS

  公开号：US20100222578A1

  公开（公告）日：2010-09-02

  A process for preparing acyl amide compounds is described, in which a recrystallized o-nitrophenoxy carbonyl compound is hydrogenated with hydrogen gas in the presence of a nickel sponge metal catalyst with ring closure to form a benzoxazine, which is then reacted with an acyl halide to give the corresponding acyl amide compound.

  描述了一种制备酰胺化合物的过程，其中将重新结晶的邻硝基苯氧羰基化合物在镍海绵金属催化剂的存在下与氢气加氢，通过环闭合形成苯并噁嗪，然后与酰卤反应得到相应的酰胺化合物。
• Inhibition of human leukocyte elastase by functionalized N-aryl azetidin-2-ones: substituent effects at C-3 and benzylic positions
  作者：I Vergely、N Boggetto、V Okochi、S Golpayegani、M Reboud-Ravaux、R Kobaiter、R Joyeau、M Wakselman

  DOI：10.1016/0223-5234(96)88226-2

  日期：1995.1

  A series of functionalized N-aryl azetidin-2-ones with a latent alkylating group was prepared by a flexible four-step synthesis. They met criteria expected for a suicide-type inactivation of human leukocyte elastase (HLE) and porcine pancreatic elastase (PPE), with no inactivation of trypsin- and chymotrypsin-like proteases. The inhibition potency was dependent on the halogen substituents at C-3 (F, F; Cl, Cl; Br, Br) and the nature and the position relative to nitrogen of the latent benzylic leaving group (F, Cl, Br). Better inactivations of HLE compared with PPE were observed with azetidinones gem-disubstituted by Cl and Br rather than by F. Their protio analogs, which are devoid of the latent quinoniminium methide electrophile, behave as simple substrates of elastases.
• Alpha dichloro-beta monochloropropionyl chloride
  申请人：WINGFOOT CORP

  公开号：US02361552A1

  公开（公告）日：1944-10-31
• New compound
  申请人：WINGFOOT CORP

  公开号：US02371766A1

  公开（公告）日：1945-03-20