Z-D-Leu-L-Ala-OH | 22209-80-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-D-Leu-L-Ala-OH
• 英文别名: Carbobenzoxy-Leu-D-Ala；(2S)-2-[[(2R)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]propanoic acid
• CAS: 22209-80-9
• 化学式: C₁₇H₂₄N₂O₅
• 分子量: 336.388
• InChiKey: CWMXJBNCYBDNTJ-GXTWGEPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Z-D-Leu-L-Ala-OH 、 L-苯丙氨酸甲酯盐酸盐 在 1-羟基苯并三唑 、 1,2-二氯乙烷 、 N,N-二异丙基乙胺 作用下， 生成
  参考文献：
  名称：

  Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues

  摘要：

  The synthesis and structure-activity relationships of zygosporamide, a known potent and selective cytotoxic natural product against SF-268 and RXF 393 cell lines, are described. The potencies of the synthetic zygosporamide are similar to those reported for the natural product toward all cancer cell lines examined with the exception of SF-268, the underlying cause of which remains to be elucidated. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.066
• 作为产物：
  描述：

  Z-D-Leu-L-Ala-OCH3 在 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 Z-D-Leu-L-Ala-OH
  参考文献：
  名称：

  Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues

  摘要：

  The synthesis and structure-activity relationships of zygosporamide, a known potent and selective cytotoxic natural product against SF-268 and RXF 393 cell lines, are described. The potencies of the synthetic zygosporamide are similar to those reported for the natural product toward all cancer cell lines examined with the exception of SF-268, the underlying cause of which remains to be elucidated. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.066

文献信息

• Karczynski,F.; Kupryszewski,G., Roczniki Chemii, 1969, vol. 43, p. 1317 - 1327
  作者：Karczynski,F.、Kupryszewski,G.

  DOI：——

  日期：——
• Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues
  作者：You Wang、Feiran Zhang、Yihua Zhang、Jun O. Liu、Dawei Ma

  DOI：10.1016/j.bmcl.2008.06.066

  日期：2008.8

  The synthesis and structure-activity relationships of zygosporamide, a known potent and selective cytotoxic natural product against SF-268 and RXF 393 cell lines, are described. The potencies of the synthetic zygosporamide are similar to those reported for the natural product toward all cancer cell lines examined with the exception of SF-268, the underlying cause of which remains to be elucidated. (c) 2008 Elsevier Ltd. All rights reserved.