1-(叔丁基)-1H-1,2,3-三唑-4-羧酸乙酯 | 98013-35-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1-(叔丁基)-1H-1,2,3-三唑-4-羧酸乙酯
• 英文名称: 1-tert-Butyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
• 英文别名: Ethyl 1-(tert-butyl)-1H-1,2,3-triazole-4-carboxylate；ethyl 1-tert-butyltriazole-4-carboxylate
• CAS: 98013-35-5
• 化学式: C₉H₁₅N₃O₂
• 分子量: 197.237
• InChiKey: KQAQHURASVLKBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  重氮乙酸乙酯 、 N,N-dimethyl tert-butylamino-formamidine 以 乙腈 为溶剂， 反应 24.0h， 以60%的产率得到1-(叔丁基)-1H-1,2,3-三唑-4-羧酸乙酯
  参考文献：
  名称：

  Untersuchungen an Diazo-Verbindungen und Aziden; LVI¹. Amino- und Iminomethylierung von Diazomethyl-Verbindungen

  摘要：

  DOI：

  10.1055/s-1985-31146

文献信息

• PROCESS FOR PREPARING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC ACIDS, ESTERS AND AMIDES
  申请人：Akebia Therapeutics, Inc.

  公开号：US20210122715A1

  公开（公告）日：2021-04-29

  Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and [3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

  本发明涉及制备[(3-羟基吡啶-2-羧基)氨基]-烷基酸，其衍生物，包括5-芳基取代和5-杂环芳基取代的[(3-羟基吡啶-2-羧基)氨基]乙酸。此外，本发明还公开了制备[(3-羟基吡啶-2-羧基)氨基]乙酸前药的方法，例如[(3-羟基吡啶-2-羧基)氨基]乙酸酯和[3-羟基吡啶-2-羧基)氨基]乙酸酰胺。所公开的化合物可用作脯氨酸羟化酶抑制剂或用于治疗需要脯氨酸羟化酶抑制的疾病的药物。
• HERBICIDAL ISOXAZOLINE COMPOUNDS
  申请人：Boehmer Jutta Elisabeth

  公开号：US20100004128A1

  公开（公告）日：2010-01-07

  Novel compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , m, R 5 , R 6 , n and Y are as defined in claim 1 ; or N-oxides, salts and optical isomers thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I), to herbicidal compositions comprising them and to methods of using them to control plants or to inhibit plant growth.

  公式（I）的新化合物：其中R1，R2，R3，R4，m，R5，R6，n和Y如权利要求1中所定义; 或其N-氧化物，盐和光学异构体。此外，本发明还涉及制备公式（I）化合物的过程，包含它们的除草剂组合物以及使用它们控制植物或抑制植物生长的方法。
• Novel Herbicides
  申请人：Black Janice

  公开号：US20090042726A1

  公开（公告）日：2009-02-12

  Compounds of formula I: wherein R 1 , R 2 , R 3 , R 4 , m, R 5 , R 6 , n and Y are as defined in claim 1 ; or N-oxides, salts and optical isomers thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I), to herbicidal compositions comprising them and to methods of using them to control plants or to inhibit plant growth.

  公式I的化合物：其中R1、R2、R3、R4、m、R5、R6、n和Y如权利要求1所定义；或其N-氧化物、盐和光学异构体。此外，本发明还涉及制备公式(I)化合物的方法，包括它们的除草剂组合物和使用它们控制植物或抑制植物生长的方法。
• Process for preparing [(3-hydroxypyridine-2-carbonyl)amino] alkanoic acids, esters and amides
  申请人：Akebia Therapeutics, Inc.

  公开号：US10738010B2

  公开（公告）日：2020-08-11

  Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and [3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

  公开了制备[(3-羟基吡啶-2-羰基)氨基]-烷酸的工艺，其衍生物包括 5-芳基取代的和 5-杂芳基取代的[(3-羟基吡啶-2-羰基)氨基}乙酸。进一步公开了制造[(3-羟基吡啶-2-羰基)氨基]乙酸原药的方法，例如[(3-羟基吡啶-2-羰基]氨基}乙酸酯和[3-羟基吡啶-2-羰基]氨基}乙酸酰胺。所公开的化合物可作为脯氨酰羟化酶抑制剂或用于治疗需要抑制脯氨酰羟化酶的病症。
• Process for preparing [(3-hydroxypyridine-2-carbonyl)amino]alkanoic acids, esters and amides
  申请人：Akebia Therapeutics, Inc.

  公开号：US11267785B2

  公开（公告）日：2022-03-08

  Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and [3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

  公开了制备[(3-羟基吡啶-2-羰基)氨基]-烷酸的工艺，其衍生物包括 5-芳基取代的和 5-杂芳基取代的[(3-羟基吡啶-2-羰基)氨基}乙酸。进一步公开了制造[(3-羟基吡啶-2-羰基)氨基]乙酸原药的方法，例如[(3-羟基吡啶-2-羰基]氨基}乙酸酯和[3-羟基吡啶-2-羰基]氨基}乙酸酰胺。所公开的化合物可作为脯氨酰羟化酶抑制剂或用于治疗需要抑制脯氨酰羟化酶的病症。