A novel type of non-enzymatic reaction during the late steps in the biosynthesis of the angucycline antibiotics urdamycins C and D
作者:J�rgen Rohr
DOI:10.1039/c39900000113
日期:——
Investigations on the latesteps in the biosynthesis of the urdamycin complex showed the surprising result that the interconversion of urdamycin A (1) into the urdamycinsC (2) and D (3) are due to non-enzymatic condensations of (1) with 4-hydroxyphenylpyruvic acid and indole-3-pyruvic acid, respectively.
Biosynthetic formation of the S-methyl group of the angucycline antibiotic urdamycin E
作者:J�rgen Rohr
DOI:10.1039/c39890000492
日期:——
Biosynthetic studies on the angucyclineantibioticurdamycinE (1), produced by Streptomyces fradiae(strain Tü 2717), resulted in methionine being the precursor of the S-methylgroup which is transfered in a unique way as an intact unit from methionine thus showing a new structural element biogenetically deriving from this amino acid; the discussed mechanism for this unusual reaction is an enzymatic