1-(环己基甲氧基)-4-碘苯 | 877603-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(环己基甲氧基)-4-碘苯
• 英文名称: 1-(cyclohexylmethoxy)-4-iodobenzene
• 英文别名: 4-cyclohexylmethoxy-1-iodobenzene
• CAS: 877603-51-5
• 化学式: C₁₃H₁₇IO
• 分子量: 316.182
• InChiKey: CSVOGOHLNJWWIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(环己基甲氧基)-4-碘苯 、 3β-胆甾烷醇 在 copper(l) iodide 、 potassium phosphate tribasic 、 4-吡咯烷基吡啶 作用下， 以 甲苯 为溶剂， 反应 10.0h， 以83%的产率得到(3S,5S,8R,9S,10S,13R,14S,17R)-3-[4-(cyclohexylmethoxy)phenoxy]-10,13-dimethyl-17-[(R)-6-methylheptan-2-yl]hexadecahydro-1H-cyclopenta[a]phenanthrene
  参考文献：
  名称：

  Ullmann CO coupling of sterically hindered secondary alcohols using excess amount of strongly coordinating monodentate ligands

  摘要：

  A new effective copper catalyzed C-O coupling reaction using excess amount of strongly coordinating monodentate ligands was successfully developed. Among the DMAP-type monodentate ligands, 4-pyrrolidinopyridine afforded the best results. The developed reaction is widely applicable for the synthesis of various hindered or acyclic secondary alkyl-aryl ethers. In this study, a novel and remarkable acceleration of the coupling reaction using excess amount of monodentate ligands was discovered. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.01.095
• 作为产物：
  描述：

  4-碘苯酚 、 溴甲基环己烷 在 potassium phosphate tribasic 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 以70%的产率得到1-(环己基甲氧基)-4-碘苯
  参考文献：
  名称：

  Ullmann CO coupling of sterically hindered secondary alcohols using excess amount of strongly coordinating monodentate ligands

  摘要：

  A new effective copper catalyzed C-O coupling reaction using excess amount of strongly coordinating monodentate ligands was successfully developed. Among the DMAP-type monodentate ligands, 4-pyrrolidinopyridine afforded the best results. The developed reaction is widely applicable for the synthesis of various hindered or acyclic secondary alkyl-aryl ethers. In this study, a novel and remarkable acceleration of the coupling reaction using excess amount of monodentate ligands was discovered. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.01.095

文献信息

• Ullmann CO coupling of sterically hindered secondary alcohols using excess amount of strongly coordinating monodentate ligands
  作者：Hayato Sugata、Tetsu Tsubogo、Yoshitaka Kino、Hiromi Uchiro

  DOI：10.1016/j.tetlet.2017.01.095

  日期：2017.3

  A new effective copper catalyzed C-O coupling reaction using excess amount of strongly coordinating monodentate ligands was successfully developed. Among the DMAP-type monodentate ligands, 4-pyrrolidinopyridine afforded the best results. The developed reaction is widely applicable for the synthesis of various hindered or acyclic secondary alkyl-aryl ethers. In this study, a novel and remarkable acceleration of the coupling reaction using excess amount of monodentate ligands was discovered. (C) 2017 Elsevier Ltd. All rights reserved.