正戊基正丁基氨基甲酸酯 | 1070-51-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 正戊基正丁基氨基甲酸酯
• 英文名称: n-pentyl n-butylcarbamate
• 英文别名: pentyl n-butylcarbamate；N-Butyl-carbamidsaeure-pentylester
• CAS: 1070-51-5
• 化学式: C₁₀H₂₁NO₂
• mdl: MFCD24388536
• 分子量: 187.282
• InChiKey: XMKYOJYUPJEGDY-UHFFFAOYSA-N

物化性质

• 沸点：
  111 °C(Press: 4 Torr)
• 密度：
  0.909±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  戊醇 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 、 四丁基碘化铵 、 potassium carbonate 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 生成 正戊基正丁基氨基甲酸酯
  参考文献：
  名称：

  AN EFFICIENT ONE POT SYNTHESIS OF CARBAMATE ESTERS THROUGH ALCOHOLIC TOSYLATES*

  摘要：

  An efficient O-alkylation of alcoholic tosylates with amines in a K2CO3/CO2 system in the presence of tetrabutyl ammonium iodide (TBAI) provides exclusive formation of carbamates.

  DOI：

  10.1081/scc-120006028

文献信息

• An Efficient, One-Pot Synthesis of Carbamates from the Corresponding Alcohols Using Mitsunobu’s Reagent
  作者：Devdutt Chaturvedi、Nisha Mishra、Virendra Mishra

  DOI：10.1007/s00706-006-0557-2

  日期：2007.1

  A novel Mitsunobu -based protocol was developed for the synthesis of carbamates from the corresponding alcohols using carbon dioxide and amines in good to excellent yields. This protocol is mild, chemoselective, and efficient compared to other reported methods.

  开发了一种新的 基于 Mitsunobu 的方案，用于使用二氧化碳和胺从相应的醇合成氨基甲酸酯，收率好至极好。与其他报道的方法相比，该方案是温和的，化学选择性的和有效的。
• PRODUCTION METHOD OF CARBAMIC ACID ESTER
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：US20190185420A1

  公开（公告）日：2019-06-20

  A method of production of carbamic acid ester has a high yield and high selectivity and is superior in economy. The method of production of a carbamic acid ester includes reacting an amine, carbon dioxide, and an alkoxysilane compound in the presence of a catalyst containing a zinc compound or an alkali metal compound or in the presence of an ionic liquid. A carbamic acid ester is produced, for example by reacting aniline, carbon dioxide, and tetramethoxysilane at a temperature of 150 to 180° C. in the presence of zinc acetate and 2,2′-bipyridine.

  一种生产氨基甲酸酯的方法具有高产率和高选择性，并在经济上优越。生产氨基甲酸酯的方法包括在催化剂的存在下，将胺、二氧化碳和烷氧基硅烷化合物反应，所述催化剂含有锌化合物或碱金属化合物或存在于离子液体中。例如，通过在150至180°C的温度下，在锌醋酸和2,2'-联吡啶的存在下，将苯胺、二氧化碳和四甲氧基硅烷反应，可以生产氨基甲酸酯。
• METHOD FOR PRODUCING CARBAMIC ACID ESTER
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP3508473A1

  公开（公告）日：2019-07-10

  A method of production of carbamic acid ester has a high yield and high selectivity and is superior in economy. The method of production of a carbamic acid ester includes reacting an amine, carbon dioxide, and an alkoxysilane compound in the presence of a catalyst containing a zinc compound or an alkali metal compound or in the presence of an ionic liquid. A carbamic acid ester is produced, for example by reacting aniline, carbon dioxide, and tetramethoxysilane at a temperature of 150 to 180°C in the presence of zinc acetate and 2,2'-bipyridine.

  一种生产氨基甲酸酯的方法具有高产率和高选择性，而且经济性更好。氨基甲酸酯的生产方法包括在含有锌化合物或碱金属化合物的催化剂存在下，或在离子液体存在下，使胺、二氧化碳和烷氧基硅烷化合物发生反应。例如，在乙酸锌和 2,2'-联吡啶的存在下，苯胺、二氧化碳和四甲氧基硅烷在 150 至 180°C 的温度下发生反应，即可制得氨基甲酸酯。
• Production method of carbamic acid ester
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：US10752579B2

  公开（公告）日：2020-08-25

  A method of production of carbamic acid ester has a high yield and high selectivity and is superior in economy. The method of production of a carbamic acid ester includes reacting an amine, carbon dioxide, and an alkoxysilane compound in the presence of a catalyst containing a zinc compound or an alkali metal compound or in the presence of an ionic liquid. A carbamic acid ester is produced, for example by reacting aniline, carbon dioxide, and tetramethoxysilane at a temperature of 150 to 180° C. in the presence of zinc acetate and 2,2′-bipyridine.

  一种生产氨基甲酸酯的方法具有高产率和高选择性，而且经济性更好。氨基甲酸酯的生产方法包括在含有锌化合物或碱金属化合物的催化剂存在下，或在离子液体存在下，使胺、二氧化碳和烷氧基硅烷化合物发生反应。例如，在乙酸锌和 2,2′-联吡啶的存在下，苯胺、二氧化碳和四甲氧基硅烷在 150 至 180 摄氏度的温度下反应，可制得氨基甲酸酯。
• Triton-B Catalyzed, Efficient, One-Pot Synthesis of Carbamate Esters from Alcoholic Tosylates
  作者：Devdutt Chaturvedi、Suprabhat Ray

  DOI：10.1007/s00706-005-0452-2

  日期：2006.4

  A novel process for the one-step chemoselective conversion of a variety of alcoholic tosylates into carbamates serving as protected an-fines was developed using benzyltrimethylammonium hydroxide (Triton-B) in the presence of gaseous carbon dioxide. Thus carbamate esters of different amines were prepared in very good to excellent yields.