1-[[4,5-双(4-甲氧基苯基)-2-噻唑]羰基]-4-甲基哌嗪盐酸盐

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1-[[4,5-双(4-甲氧基苯基)-2-噻唑]羰基]-4-甲基哌嗪盐酸盐
• 英文名称: [4,5-bis(4-methoxyphenyl)-1,3-thiazol-2-yl]-(4-methylpiperazin-1-yl)methanone;hydron;chloride
• 化学式: C23H26ClN3O3S
• 分子量: 460.0
• InChiKey: YWMAVHIKOAOSFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Thiazole compounds, processes for the preparation thereof, and pharmaceutical composition comprising the same
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0377457A1

  公开（公告）日：1990-07-11

  The present invention relates to new thiazole compounds and pharmaceutically acceptable salts thereof which have pharmacological activities, processes for preparation thereof, a pharmaceutical composition comprising the same same and a use of the same.

  本发明涉及具有药理活性的新噻唑化合物及其药学上可接受的盐、其制备工艺、包含相同物质的药物组合物以及相同物质的用途。
• USE OF COMPOUNDS FOR THE TREATMENT OF PAIN
  申请人：Akron Molecules AG

  公开号：EP2846788A1

  公开（公告）日：2015-03-18
• NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS
  申请人：Chen Chien-Hung

  公开号：US20120183600A1

  公开（公告）日：2012-07-19

  The invention relates to a composition that includes a first agent selected from the group consisting of an oxidative phosphorylation inhibitor, an ionophore, and an adenosine 5′-monophosphate-activated protein kinase (AMPK) activator; a second agent that possesses anti-inflammatory activity; and a third agent that possesses serotonin activity.
• Methods for Reducing Recurrence of Tumors
  申请人：Beth Israel Deaconess Medical Center, Inc.

  公开号：US20190290614A1

  公开（公告）日：2019-09-26

  Methods of reducing the risk of cancer after surgery, e.g., of cancer recurrence, by administering COX-1 selective inhibitors prior to surgery or biopsy. Alternatively or in addition, other anti-platelet agents and/or TGF-β inhibition and/or IL-6 inhibition and/or inhibitors of the PD-1/PD-L1 axis, as well as combinations thereof.
• US5217971A
  申请人：——

  公开号：US5217971A

  公开（公告）日：1993-06-08