1-吗啉-4-基-丁烷-2-醇 | 3140-35-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 1-吗啉-4-基-丁烷-2-醇
• 英文名称: 1-morpholin-4-yl-butan-2-ol
• 英文别名: 1-morpholino-butan-2-ol；1-Morpholino-2-butanol；1-(Morpholin-4-yl)butan-2-ol；1-morpholin-4-ylbutan-2-ol
• CAS: 3140-35-0
• 化学式: C₈H₁₇NO₂
• 分子量: 159.228
• InChiKey: UCBNFSNJAAJCJL-UHFFFAOYSA-N

物化性质

• 沸点：
  67-69 °C(Press: 1 Torr)
• 密度：
  1.027 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2-环氧丁烷 、 吗啉 在 copper(II) ferrite 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到1-吗啉-4-基-丁烷-2-醇
  参考文献：
  名称：

  Efficient synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines catalyzed by CuFe2O4 nanoparticles

  摘要：

  开发了一种简单高效的方法，通过在室温下利用CuFe2O4纳米颗粒作为不溶性可回收催化剂，配合胺选择性地开启环氧化合物环，以高产率合成了β-氨基醇。

  DOI：

  10.1007/s13738-013-0241-5

文献信息

• 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Genentech, Inc.

  公开号：US20150336962A1

  公开（公告）日：2015-11-26

  Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

  这里描述了化合物的公式（00A）及其作为Janus激酶抑制剂的使用方法。
• [EN] MORPHOLINYL CONTAINING BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION<br/>[FR] BENZIMIDAZOLES CONTENANT DU MORPHOLINYLE EN TANT QU'INHIBITEURS DE LA REPLICATION DU VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：TIBOTEC PHARM LTD

  公开号：WO2005058871A1

  公开（公告）日：2005-06-30

  The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I), a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein G is a direct bond or optionally substituted C1-10alkanediyl; Rl is Ar1 or a monocyclic or bicyclic heterocycle Q is R7, pyrrolidinyl substituted with R7, piperidinyl substituted with R7 or homopiperidinyl substituted with R7; one of R2a and R3a is selected from halo, optionally mono- or polysubstituted Cl-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4), N(R4aR4)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2Cl-6alkyloxy, carboxyl, Cl-6alkyloxycarbonyl, or -C(=Z)Ar2; and the other one of R2a and R3a is hydrogen; in case R2a is different from hydrogen then R2b is hydrogen, C1-6alkyl or halogen and R3b is hydrogen; in case R3a is different from hydrogen then R3b is hydrogen, C1-6alkyl or halogen and R2b is hydrogen. It further concerns the preparation thereof and compositions comprising these compounds, as well as the use thereof as a medicine.

  本发明涉及含有对呼吸道合胞病毒复制具有抑制活性的吗啉基苯并咪唑的化合物，其具有式（I），一种前药、N-氧化物、加合盐、季铵盐、金属配合物或其立体化异构体，其中G是直键或可选择地取代的C1-10烷二基；R1是Ar1或单环或双环杂环；Q是R7，R7取代的吡咯烷基、R7取代的哌啶基或R7取代的同构异哌啶基；R2a和R3a中的一个选自卤素、可选择单取代或多取代的Cl-6烷基、可选择单取代或多取代的C2-6烯基、硝基、羟基、Ar2、N(R4aR4)、N(R4aR4)磺酰基、N(R4aR4b)羰基、C1-6烷氧基、Ar2氧基、Ar2Cl-6烷氧基、羧基、Cl-6烷氧羰基或-C(=Z)Ar2；R2a和R3a中的另一个是氢；如果R2a与氢不同，则R2b是氢、C1-6烷基或卤素，R3b是氢；如果R3a与氢不同，则R3b是氢、C1-6烷基或卤素，R2b是氢。还涉及其制备以及包含这些化合物的组合物，以及其作为药物的用途。
• Compounds Useful as Immunomodulators
  申请人：Bristol-Myers Squibb Company

  公开号：US20150291549A1

  公开（公告）日：2015-10-15

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本公开涉及一般用作免疫调节剂的化合物。提供的是包含这些化合物的化合物、组合物以及它们的使用方法。本公开还涉及包含至少一种根据本公开的化合物的药物组合物，用于治疗各种疾病，包括癌症和传染病。
• Lithium trifluoromethanesulfonate-catalysed aminolysis of oxiranes
  作者：Jacques Augé、Frédéric Leroy

  DOI：10.1016/0040-4039(96)01731-5

  日期：1996.10

  The aminolysis of oxiranes was found to be catalysed by lithium trifluoromethanesulfonate in acetonitrile solutions. This salt turned out to be an excellent substitute for the unsafe lithium perchlorate.

  发现环氧乙烷的氨解是由三氟甲烷磺酸锂在乙腈溶液中催化的。事实证明，这种盐是不安全的高氯酸锂的极好的替代品。
• 5-Substituted 1-Phenyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones and Analogs as Anti-Virals
  申请人：Kesteleyn Rudolf Romanie Bart

  公开号：US20070238727A1

  公开（公告）日：2007-10-11

  Compounds of formula (I) the N-oxides, salts, stereoisomeric forms, prodrugs, esters and metabolites thereof, wherein X is NR 2 , O, S, SO, SO 2 ; R 1 is hydrogen, cyano, halo, a carbonyl derivative, methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C 1-4 alkyl)-methanimidamidyl, Het 1 or Het 2 ; n is 1, 2 or 3; R 2 is (i) aryl substituted with a radical —COOR 4 ; (ii) C 1-10 alkyl, C 2-10 alkenyl, C 3-7 cycloalkyl, substituted with aryl which is substituted with a radical —COOR 4 ; (iii) C 1-10 alkyl, C 2-10 alkenyl, C 3-7 cycloalkyl, substituted with —NR 5a —C(═NR 5b )—NR 5c R 5d , —O—NR 5a —C(═NR 5b )—NR 5c R 5d , -sulfonyl-R 6 , —NR 7 R 8 , —NR 9 R 10 , a radical (a-1), (a-2), (a-3), (a-4), (a-5); or (iv) a radical of formula: (a-6), (b-2), —C p H 2p —CH(OR 14 )—C q H 2q —R 15 ; —CH 2 —CH 2 —(O—CH 2 —CH 2 ) m —OR 14 ; —CH 2 —CH 2 —(O—CH 2 —CH2) m —NR 17a R 17b ; R 3 is nitro, cyano, amino, halo, hydroxy, C 1-4 alkyloxy, a carbonyl derivative, methanimidamidyl, mono- or di(C 1-4 alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het 1 .

  化合物的公式（I），包括其N-氧化物、盐、立体异构体形式、前药、酯和代谢物，其中X是NR2、O、S、SO、SO2；R1是氢、氰、卤素、一个羰基衍生物、甲酰亚胺基、N-羟甲酰亚胺基、单个或双个（C1-4烷基）-甲酰亚胺基、Het1或Het2；n为1、2或3；R2是（i）芳基，其被基团—COOR4取代；（ii）C1-10烷基、C2-10烯基、C3-7环烷基，被芳基取代，该芳基被基团—COOR4取代；（iii）C1-10烷基、C2-10烯基、C3-7环烷基，被—NR5a—C（═NR5b）—NR5cR5d、—O—NR5a—C（═NR5b）—NR5cR5d、-磺酰基-R6、—NR7R8、—NR9R10、一个基团（a-1）、（a-2）、（a-3）、（a-4）、（a-5）取代；或（iv）公式的基团：（a-6）、（b-2）、—CpH2p—CH（OR14）—CqH2q—R15；—CH2— —（O— — ）m—OR14；— — —（O— — ）m—NR17aR17b；R3是硝基、氰基、氨基、卤素、羟基、C1-4烷氧基、一个羰基衍生物、甲酰亚胺基、单个或双个（C1-4烷基）甲酰亚胺基、N-羟甲酰亚胺基或Het1。