1-氨基-4-(4-甲基苯氧基)丁烷 | 75716-46-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-氨基-4-(4-甲基苯氧基)丁烷
• 英文名称: 1-Amino-4-(4-methylphenoxy)butane
• 英文别名: 4-(p-tolyloxy)butan-1-amine；4-p-tolyloxy-butylamine；(δ-Amino-butyl)-p-tolyl-aether；δ-p-Kresoxy-butylamin；4-(4-methylphenoxy)butylamine；1-(4-Aminobutoxy)-4-methylbenzene；4-(4-methylphenoxy)butan-1-amine
• CAS: 75716-46-0
• 化学式: C₁₁H₁₇NO
• mdl: MFCD09807731
• 分子量: 179.262
• InChiKey: NCAJSWHJILCMSV-UHFFFAOYSA-N

物化性质

• 沸点：
  293.6±23.0 °C(Predicted)
• 密度：
  0.980±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-氨基-4-(4-甲基苯氧基)丁烷 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 四氯化碳 、 氯苯 、 苯 为溶剂， 反应 5.5h， 生成 1-Isocyanato-4-(4-(bromomethyl)phenoxy)butane
  参考文献：
  名称：

  New, easily removable poly(ethylene glycol) supports for the liquid-phase method of peptide synthesis

  摘要：

  DOI：

  10.1021/jo01314a032
• 作为产物：
  描述：

  1-(4-溴丁氧基)-4-甲苯 在 氨 作用下， 反应 72.0h， 以91%的产率得到1-氨基-4-(4-甲基苯氧基)丁烷
  参考文献：
  名称：

  New, easily removable poly(ethylene glycol) supports for the liquid-phase method of peptide synthesis

  摘要：

  DOI：

  10.1021/jo01314a032

文献信息

• Inhibitors of VEGF receptor and HGF receptor signaling
  申请人：Saavedra Mario Oscar

  公开号：US20070004675A1

  公开（公告）日：2007-01-04

  The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  该发明涉及抑制VEGF受体信号和HGF受体信号。该发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。该发明还提供了治疗细胞增殖性疾病和病况的组合物和方法。
• Imidazole compounds
  申请人：——

  公开号：US20020058659A1

  公开（公告）日：2002-05-16

  A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

  一种新型的咪唑杂环化合物类，包括它们的药物组合物以及在治疗和/或预防与组织胺H3受体相关的疾病和疾病的用途。更具体地说，这些化合物对于治疗和/或预防与组织胺H3受体相互作用有益的疾病和疾病是有用的。
• Novel reagents for directed biomarker signal amplification
  申请人：Gaylord Brent S.

  公开号：US20110256550A1

  公开（公告）日：2011-10-20

  Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

  本文描述了涉及中性共轭聚合物的方法、组合物和制品，包括合成中性共轭水溶性聚合物的方法，其中包括沿聚合物主链结构的连接物和末端封端单元。这种聚合物可以用于制造新型光电器件和高效生物传感器的开发。本发明还涉及这些聚合物在测定方法中的应用。
• Novel Reagents for Directed Biomarker Signal Amplification
  申请人：Gaylord Brent S.

  公开号：US20110257374A1

  公开（公告）日：2011-10-20

  Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

  本文描述了涉及中性共轭聚合物的方法、组合物和制造品，包括合成带有连接物的中性共轭水溶性聚合物的方法，以及端基封闭单元。这些聚合物可用于制造新型光电器件，以及开发高效的生物传感器。本发明进一步涉及这些聚合物在测定方法中的应用。
• NOVEL REAGENTS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION
  申请人：Sirigen II Limited

  公开号：EP3981819A2

  公开（公告）日：2022-04-13

  Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

  本文描述的是涉及中性共轭聚合物的方法、组合物和制造品，包括合成中性共轭水溶性聚合物的方法，该聚合物沿聚合物主链结构具有连接体和末端封端单元。这种聚合物可用于制造新型光电器件和开发高效生物传感器。本发明还涉及这些聚合物在检测方法中的应用。