1-溴-1,2,2-三氟乙烷 | 430-90-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 中文名称: 1-溴-1,2,2-三氟乙烷
• 英文名称: 1-Bromo-1,2,2-trifluoroethane
• 英文别名: 1-bromo-1,2,2-trifluoro-ethane；1-Brom-1,2,2-trifluor-aethan；1,2,2-Trifluor-1-brom-ethan；1-Brom-1,2,2-trifluoraethan；Ethane, 1-bromo-1,2,2-trifluoro-
• CAS: 430-90-0
• 化学式: C₂H₂BrF₃
• 分子量: 162.937
• InChiKey: XEQSOPGUJKNNRQ-UHFFFAOYSA-N

物化性质

• 沸点：
  40-41 °C(Press: 735 Torr)
• 密度：
  1.874 g/cm3(Temp: 10 °C)
• 保留指数：
  450

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2903799090

反应信息

• 作为反应物：
  描述：

  1-溴-1,2,2-三氟乙烷 在 乙醇 、 锌 作用下， 生成 1,2-二氟乙烯
  参考文献：
  名称：

  540.在不饱和体系中添加自由基。第十四部分。自由基向三氟乙烯加成的方向

  摘要：

  DOI：

  10.1039/jr9570002800
• 作为产物：
  描述：

  三氯乙烯 在 氢溴酸 作用下， 生成 1-bromo-1,1,2-trifluoro-ethane 、 1-溴-1,2,2-三氟乙烷
  参考文献：
  名称：

  540.在不饱和体系中添加自由基。第十四部分。自由基向三氟乙烯加成的方向

  摘要：

  DOI：

  10.1039/jr9570002800

文献信息

• Iodine Excess and Hyperthyroidism
  作者：Elio Roti、Ettore Degli Uberti

  DOI：10.1089/105072501300176453

  日期：2001.5

  150 mug iodine are daily required for thyroid hormone synthesis. The thyroid gland has intrinsic mechanisms that maintain normal thyroid function even in the presence of iodine excess. Large quantities of iodide are present in drugs, antiseptics, contrast media and food preservatives. Iodine induced hyperthyroidism is frequently observed in patients affected by euthyroid iodine deficient goiter when suddenly exposed to excess iodine. Possibly the presence of autonomous thyroid function permits the synthesis and release of excess quantities of thyroid hormones. The presence of thyroid autoimmunity in patients residing in iodine-insufficient areas who develop iodine-induced hyperthyroidism has not been unanimously observed. In iodine-sufficient areas, iodine-induced hyperthyroidism has been reported in euthyroid patients with previous thyroid diseases. Euthyroid patients previously treated with antithyroid drugs for Graves' disease are prone to develop iodine-induced hyperthyroidism. As well, excess iodine in hyperthyroid Graves' disease patients may reduce the effectiveness of the antithyroid drugs. Occasionally iodine-induced hyperthyroidism has been observed in euthyroid patients with a previous episode of post-partum thyroiditis, amiodarone destructive or type II thyrotoxicosis and recombinant interferon-cu induced destructive thyrotoxicosis. Amiodarone administration may induce thyrotoxicosis. Two mechanisms are responsible for this condition. One is related to excess iodine released from the drug, approximately 9 mg of iodine following a daily dose of 300 mg amiodarone. This condition is an iodine-induced thyrotoxicosis or type I amiodarone-induced thyrotoxicosis. The other mechanism is due to the amiodarone molecule that induces a destruction of the thyroid follicles with a release of preformed hormones. This condition is called amiodarone-induced destructive thyrotoxicosis or type II thyrotoxicosis. Patients developing type I thyrotoxicosis in general have preexisting nodular goiter whereas those developing type II thyrotoxicosis have a normal thyroid gland. The latter group of patients, after recovering from the destructive process, may develop permanent hypothyroidism as the consequence of fibrosis of the gland.
• Henne; Renoll, Journal of the American Chemical Society, 1936, vol. 58, p. 888
  作者：Henne、Renoll

  DOI：——

  日期：——
• 540. Addition of free radicals to unsaturated systems. Part XIV. The direction of radical addition to trifluoroethylene
  作者：R. N. Haszeldine、B. R. Steele

  DOI：10.1039/jr9570002800

  日期：——