1-溴-2-丁氧基苯 | 54514-30-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-溴-2-丁氧基苯
• 英文名称: 1-bromo-2-butoxybenzene
• 英文别名: 1-bromo-2-n-butoxybenzene；(2-bromo-phenyl)-butyl ether；(2-Brom-phenyl)-butyl-aether；1-bromo-2-butoxy-phenyl；n-butyloxybromobenzene；1-butoxybromobenzene
• CAS: 54514-30-6
• 化学式: C₁₀H₁₃BrO
• mdl: MFCD09942935
• 分子量: 229.117
• InChiKey: HFEFLNNDSLOUEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  1-溴-2-丁氧基苯 在 2-双环己基膦-2',6'-二甲氧基联苯 、 palladium diacetate 、 sodium t-butanolate 、 三氯氧磷 作用下， 以 甲苯 为溶剂， 生成 4-(2-n-butoxyphenyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indole-7-carbaldehyde
  参考文献：
  名称：

  N-(2-Alkoxyphenyl)-substituted double rhodanine indoline dyes for zinc oxide dye-sensitized solar cell

  摘要：

  The effect of N-(2-alkoxyphenyl) group in double rhodanine indoline dye on the performance of zinc oxide dye-sensitized solar cell was examined. Both J(sc) and V-oc were improved by introducing long alkoxy group due to prevention of H-aggregates formation and inhibition of electron recombination from zinc oxide surface to electrolyte. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.060
• 作为产物：
  描述：

  1-碘丁烷 、 2-溴苯酚 在 sodium hydroxide 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以66%的产率得到1-溴-2-丁氧基苯
  参考文献：
  名称：

  N-(2-Alkoxyphenyl)-substituted double rhodanine indoline dyes for zinc oxide dye-sensitized solar cell

  摘要：

  The effect of N-(2-alkoxyphenyl) group in double rhodanine indoline dye on the performance of zinc oxide dye-sensitized solar cell was examined. Both J(sc) and V-oc were improved by introducing long alkoxy group due to prevention of H-aggregates formation and inhibition of electron recombination from zinc oxide surface to electrolyte. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.060

文献信息

• Process for the production of styrene compound, and styrene compound free from biphenyl
  申请人：Tosoh Corporation

  公开号：US20020026084A1

  公开（公告）日：2002-02-28

  A process for the production of a styrene compound is provided. The process comprises reacting a Grignard reagent prepared from a tertiary butoxyphenyl halide with a vinyl halide in the presence of a catalyst, wherein the catalyst is at least one member selected from the group consisting of manganese catalyst, iron catalyst, cobalt catalyst and rhodium catalyst. The process overcomes the problems involved in the prior art, and is economical and safe. The styrene compound by the process is free from biphenyl.

  提供一种生产苯乙烯化合物的方法。该方法包括在存在催化剂的情况下，将从三丁氧基苯基卤化物制备的格氏试剂与乙烯卤化物反应，其中催化剂至少选自锰催化剂、铁催化剂、钴催化剂和铑催化剂组成的群体中的一种。该方法克服了先前技术中涉及的问题，经济且安全。该方法生产的苯乙烯化合物不含联苯。
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：GLAXO GROUP LTD

  公开号：WO2013029338A1

  公开（公告）日：2013-03-07

  Disclosed are novel retinoid-related orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.

  揭示了一种新型的视黄醇相关孤儿受体γ（RORγ）调节剂，以及它们在治疗由RORγ介导的疾病中的用途。
• [EN] NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS UTILISÉS COMME INHIBITEURS DE DIACYLGLYCÉROL ACYLTRANSFÉRASE
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2014081994A1

  公开（公告）日：2014-05-30

  This invention relates to novel compounds which are inhibitors of acyl coenzyme A: diacylglycerol acyltransferase 1 (DGAT-1 ), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination with weight management therapies or other triglyceride lowering therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit.

  本发明涉及一种新型化合物，它们是酰基辅酶A：二酰基甘油酰基转移酶1（DGAT-1）的抑制剂，以及含有它们的药物组合物，其制备方法，以及它们在治疗中的使用，单独或与体重管理疗法或其他三酸甘油酯降低疗法结合使用，用于预防或治疗与DGAT-1功能障碍相关的疾病或调节DGAT-1活性可能具有治疗益处的疾病。
• Sulfamato hydroxamic acid metalloprotease inhibitor
  申请人：Boehm L. Terri

  公开号：US20050049280A1

  公开（公告）日：2005-03-03

  A sulfamato hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a process for preparing the same, intermediate compounds useful in those syntheses, and a treatment process that comprises administering a contemplated sulfamato hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

  本发明公开了一种磺酰氨基羟肟酸化合物，该化合物在抑制基质金属蛋白酶活性方面具有作用，同时还公开了制备该化合物的方法，用于该合成的中间化合物以及治疗过程，该治疗过程包括向具有与病理基质金属蛋白酶活性相关的病情的宿主中以MMP酶抑制有效量的考虑中的磺酰氨基羟肟酸化合物的方式进行给药。
• LIQUID CRYSTAL COMPOUND HAVING NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE USING THE SAME
  申请人：Yamashita Junichi

  公开号：US20120190897A1

  公开（公告）日：2012-07-26

  The invention provides a liquid crystal compound having general physical properties necessary for the liquid crystal compound, namely, stability to heat, light and so forth, a small viscosity, a refractive index anisotropy having a suitable magnitude value, a dielectric anisotropy having a suitable magnitude value, steep electrooptical characteristics, a wide temperature range of a nematic phase, and an excellent compatibility with other liquid crystal compounds, in particular, a liquid crystal compound having a wide temperature range of the nematic phase; a compound represented by formula (i): wherein, for example, R 1 and R 2 are alkyl having 1 to 8 carbons or alkenyl having 2 to 8 carbons; ring A 1 is trans-1,4-cyclohexylene or 1,4-phenylene; ring A 2 is trans-1,4-cyclohexylene or 2,3-difluoro-1,4-phenylene; Q 1 and Q 2 are fluorine or chlorine; and h is 0, 1 or 2.

  本发明提供了一种液晶化合物，具有液晶化合物所需的一般物理性能，即耐热、耐光等稳定性，小粘度，适当大小的折射率各向异性，适当大小的介电各向异性，陡峭的电光特性，宽的向列相温度范围，以及与其他液晶化合物的优异相容性，特别是一种具有宽的向列相温度范围的液晶化合物；其中，化合物的结构式为（i）：其中，例如，R1和R2是具有1至8个碳或2至8个碳的烷基或烯基；环A1是反-1,4-环己基或1,4-苯基；环A2是反-1,4-环己基或2,3-二氟-1,4-苯基；Q1和Q2是氟或氯；h为0、1或2。