(Alkoxyallyl)sulfones as enal and enone β-anion equivalents. Synthesis of mono-, di- and trisubtituted furans
摘要:
Treatment of variously-substituted (alkoxyallyl)sulfones 1, 7-9 with strong base followed by aldehydes gives alcohol adducts 5. These may be converted into a wide range of substituted furans 6 by exposure to acid, or to silica gel in dichloromethane containing sulfuric acid in some cases. Copyright (C) 1996 Elsevier Science Ltd
PYRROLOPYRAZINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
申请人:Hadida Ruah Sara Sabina
公开号:US20120196869A1
公开(公告)日:2012-08-02
The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Disclosed are novel compounds having the structure of Formula (I):
which are useful for treating mammals for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a dopamine-producing agent.
[EN] DIACYLGLYCEROL KINASE MODULATING COMPOUNDS<br/>[FR] COMPOSÉS MODULANT LA DIACYLGLYCÉROL KINASE
申请人:CARNA BIOSCIENCES INC
公开号:WO2021130638A1
公开(公告)日:2021-07-01
The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
Organic Reactions in Ionic Liquids: A New Method for the Synthesis of Alkyl Aryl Sulfones by Alkylation of Sodium Arenesulfinates with Unactivated Alkyl Chlorides
作者:Yi Hu、Zhen‐Chu Chen、Zhang‐Gao Le、Qin‐Guo Zheng
DOI:10.1081/scc-200034831
日期:2004.12.31
Abstract A newmethod is reported for the synthesis of alkyl aryl sulfones by alkylation of sodium arenesulfinates with unactivated alkyl chlorides using ionic liquid based on 1‐butyl‐3‐methylimidazolium tetrafluoroborate (BmimBF4) mixed with water (2:1) as reaction media. The ionic liquid can be reused and the procedure gives the sulfones in moderate yields.
POLY(ORGANOPHOSPHAZENE) COMPOSITION FOR BIOMATERIALS
申请人:SONG Soo-Chang
公开号:US20130004455A1
公开(公告)日:2013-01-03
Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.