1-甲基-5-(三氟甲基)吡啶-2-酮 | 201160-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-甲基-5-(三氟甲基)吡啶-2-酮
• 英文名称: 1-methyl-5-(trifluoromethyl)pyridin-2(1H)-one
• 英文别名: 2(1H)-Pyridinone, 1-methyl-5-(trifluoromethyl)-；1-methyl-5-(trifluoromethyl)pyridin-2-one
• CAS: 201160-48-7
• 化学式: C₇H₆F₃NO
• mdl: MFCD00722685
• 分子量: 177.126
• InChiKey: GARXKEYFZZSFPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-甲基-5-(三氟甲基)吡啶-2-酮 在 dipotassium peroxodisulfate 、 cerium(III) nitrate hexahydrate 、 三氟乙酸 、 sodium iodide 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 以80%的产率得到3-iodo-1-methyl-5-(trifluoromethyl)pyridin-2(1H)-one
  参考文献：
  名称：

  喹啉，喹诺酮类，吡啶酮，吡啶和尿嘧啶的区域选择性碘化

  摘要：

  已经开发出基于自由基的直接CH碘化方案，用于喹啉，喹诺酮，吡啶酮，吡啶和尿嘧啶。碘化以喹啉和喹诺酮类化合物的C3选择性方式发生。吡啶酮...

  DOI：

  10.1039/c5cc07799k
• 作为产物：
  描述：

  2-溴-5-(三氟甲基)吡啶 在 potassium tert-butylate 作用下， 以 1,4-二氧六环 、 2-甲基-2-丁醇 为溶剂， 反应 82.0h， 生成 1-甲基-5-(三氟甲基)吡啶-2-酮
  参考文献：
  名称：

  Asymmetric Homogeneous Hydrogenation of 2-Pyridones

  摘要：

  An asymmetric homogeneous hydrogenation of 2(1H)-pyridones has been developed, using a ruthenium complex bearing two chiral N-heterocyclic carbene (NHC) ligands. To the best of our knowledge, the presented reaction is the first example of a homogeneous asymmetric conversion of 2-pyridones into the corresponding enantioenriched 2-piperidones.

  DOI：

  10.1055/s-0034-1378703

文献信息

• 2-Amino-quinazolin-5-ones
  申请人：Bellamacina R. Cornelia

  公开号：US20070027150A1

  公开（公告）日：2007-02-01

  2-Amino-quinazolin-5-one compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cell proliferative diseases.

  2-氨基喹唑啉-5-酮化合物，立体异构体，互变异构体，药学上可接受的盐及其前药；包括药学上可接受的载体和一种或多种2-氨基喹唑啉-5-酮化合物的组合物，可以单独使用或与至少一种额外治疗剂结合使用。使用2-氨基喹唑啉-5-酮化合物的方法，可以单独使用或与至少一种额外治疗剂结合使用，用于预防或治疗细胞增殖性疾病。
• NOVEL SUBSTITUTED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
  申请人：Van Brandt Sven Franciscus Anna

  公开号：US20120295891A1

  公开（公告）日：2012-11-22

  The present invention is concerned with novel substituted triazole derivatives of Formula (I) wherein Het 1 , R 1 , R 2 , A 1 , A 2 , A 3 , A 4 , L 1 , and L 2 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

  本发明涉及具有以下式（I）的新型取代三唑衍生物，其中Het1，R1，R2，A1，A2，A3，A4，L1和L2的含义如权利要求中所定义。根据本发明的化合物可用作γ-分泌酶调节剂。本发明还涉及制备这种新型化合物的方法，包括将所述化合物作为活性成分的药物组合物以及将所述化合物用作药物的用途。
• PIPERIDINE AND PYRROLIDINE DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISM
  申请人：Sakagami Masahiro

  公开号：US20110319412A1

  公开（公告）日：2011-12-29

  The present invention discloses novel piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonistic activity. Specifically, the present invention discloses a compound represented by the formula (I), a pharmaceutically acceptable salt or a solvate thereof: wherein A is substituted or unsubstituted monocyclic aryl or monocyclic heterocyclyl; X is a single bond or C(═O); Y is a single bond, CR 5 R 6 NR 7 or C(═O)NR 7 ; R 1 and R 2 are independently hydrogen or substituted or unsubstituted alkyl; R 3 is substituted or unsubstituted aryl or heterocyclyl; R 4 is halogen, substituted or unsubstituted alkyl, alkoxy, aryloxy or heterocyclyloxy, etc.; p is an integer of 0 to 2; q is 0 or 1; m is 0 or 1; n is an integer of 0 to 5; and B is aromatic carbocycle, monocyclic heterocycle or bicyclic fused hetero ring.

  本发明公开了具有NPY Y5受体拮抗活性的新型哌啶和吡咯烷衍生物。具体地，本发明公开了由以下式（I）表示的化合物，其药学上可接受的盐或溶剂：其中A是取代或未取代的单环芳基或单环杂环基；X是单键或C(═O)；Y是单键，CR5R6NR7或C(═O)NR7；R1和R2独立地是氢或取代或未取代的烷基；R3是取代或未取代的芳基或杂环基；R4是卤素，取代或未取代的烷基，烷氧基，芳基氧基或杂环氧基等；p是0到2的整数；q是0或1；m是0或1；n是0到5的整数；B是芳香碳环，单环杂环或融合的双环杂环。
• Topical compositions comprising protected functional thiols
  申请人：——

  公开号：US20020012639A1

  公开（公告）日：2002-01-31

  This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr) m where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. Preferred embodiments of the present invention provide a modified UV absorber and a modified antioxidant, methods for making them and compositions conprising them.

  这项发明涉及一种用于处理氨基酸基底的局部组合物，包括具有以下结构的受保护硫化合物R—(S—Pr)m，其中R是功能基团，S是硫，Pr是一个杂环保护基团，m是介于1和100之间的整数。该发明还涉及包含该受保护硫化合物和一个活化机制的系统。本发明的受保护硫化合物可用于头发护理组合物、纺织品护理组合物、化妆品组合物、口腔护理组合物、皮肤护理、指甲护理、洗涤护理、痤疮护理和动物护理组合物。本发明的优选实施例提供了一种改性紫外线吸收剂和一种改性抗氧化剂，以及制备它们和包含它们的组合物的方法。
• Iron-Catalyzed Regioselective Direct Arylation at the C-3 Position of <i>N</i>-Alkyl-2-pyridone
  作者：Atanu Modak、Sujoy Rana、Debabrata Maiti

  DOI：10.1021/jo502362k

  日期：2015.1.2

  A number of pharmaceutical compounds possess an arylated 2-pyridone moiety. The existing reports using expensive starting materials and/or superstoichiometric metal salts have prompted us to explore a possible user-friendly method for their synthesis. In this report, we demonstrate an easy-to-handle reaction condition with an iron catalyst for the exclusive generation of C-3-arylated pyridone via C–H

  许多药物化合物具有芳基化的2-吡啶酮部分。使用昂贵的起始原料和/或超化学计量金属盐的现有报道促使我们探索一种可能的用户友好的合成方法。在本报告中，我们证明了使用铁催化剂通过C–H官能化独家生成C-3-芳基吡啶酮的反应条件易于处理。