氨基-六聚乙二醇-甲酯 | 1314378-15-8

• 物质功能分类: 催化剂及助剂 - 聚合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 氨基-六聚乙二醇-甲酯
• 英文名称: 4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-amino-, methyl ester
• 英文别名: methyl 3-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• CAS: 1314378-15-8
• 化学式: C₁₆H₃₃NO₈
• 分子量: 367.43
• InChiKey: AXHJIJHDXBZLOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  25
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] DIRECTED CONJUGATION TECHNOLOGIES<br/>[FR] TECHNOLOGIES DE CONJUGAISON DIRIGÉE
  申请人：KLEO PHARMACEUTICALS INC

  公开号：WO2021102052A1

  公开（公告）日：2021-05-27

  Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates.

  本公开提供了用于将各种感兴趣的分子与目标剂进行定点偶联的技术。在某些实施方式中，本公开利用目标结合分子以提供高偶联效率和选择性。在某些实施方式中，所提供的技术可用于制备抗体偶联物。
• Intra-droplet surface engineering to capture a molecular target
  申请人：UNIVERSITE DE STRASBOURG

  公开号：US11181521B2

  公开（公告）日：2021-11-23

  The present invention relates to a method for capturing a molecular target present in the aqueous phase of a water-in-oil emulsion, said method being based on the use of a binding system comprising (a) a surfactant bearing a functional moiety on its hydrophilic head group and (b) a chemoprobe that acts as a molecular staple between the functionalized surfactant and the molecular target and comprises at least two distinct domains namely (i) at least one capture moiety which is able to specifically bind the molecular target and (ii) at least one binding domain which is able to interact with the functional group of the surfactant through covalent or non-covalent interactions, directly or through a binding intermediary.

  本发明涉及一种捕获油包水型乳液水相中分子目标的方法、该方法基于结合系统的使用，结合系统包括：(a) 表面活性剂，其亲水头基上带有官能团；(b) 化学探针，作为官能化表面活性剂和分子目标物之间的分子钉书针，至少包括两个不同的结构域，即：(i) 至少一个捕获分子，能够特异性地结合分子目标物；(ii) 至少一个结合结构域，能够通过共价或非共价相互作用，直接或通过结合中间体与表面活性剂的官能团相互作用。
• INTRA-DROPLET SURFACE ENGINEERING TO CAPTURE A MOLECULAR TARGET
  申请人：Université de Strasbourg

  公开号：EP3440463B1

  公开（公告）日：2020-07-08
• [EN] INTRA-DROPLET SURFACE ENGINEERING TO CAPTURE A MOLECULAR TARGET<br/>[FR] INGÉNIERIE DE SURFACE INTRA-GOUTTELETTE POUR CAPTURER UNE CIBLE MOLÉCULAIRE
  申请人：UNIV STRASBOURG

  公开号：WO2017174610A1

  公开（公告）日：2017-10-12

  The present invention relates to a method for capturing a molecular target present in the aqueous phase of a water-in-oil emulsion, said method being based on the use of a binding system comprising (a) a surfactant bearing a functional moiety on its hydrophilic head group and (b) a chemoprobe that acts as a molecular staple between the functionalized surfactant and the molecular target and comprises at least two distinct domains namely (i) at least one capture moiety which is able to specifically bind the molecular target and (ii) at least one binding domain which is able to interact with the functional group of the surfactant through covalent or non-covalent interactions, directly or through a binding intermediary.