1-碘-2,5-二甲基-4-甲氧基苯 | 90609-46-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-碘-2,5-二甲基-4-甲氧基苯
• 英文名称: 4-Iodo-2,5-dimethylanisole
• 英文别名: 4-Iod-2,5-dimethyl-anisol；1-Iodo-4-methoxy-2,5-dimethylbenzene
• CAS: 90609-46-4
• 化学式: C₉H₁₁IO
• mdl: MFCD07779016
• 分子量: 262.09
• InChiKey: JQIQNJPSOYOMID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,5-二甲基苯甲醚 在 N,N,N-trimethylbenzenemethanaminium dichloroiodate 、 zinc(II) chloride 作用下， 以 溶剂黄146 为溶剂， 反应 0.5h， 以98%的产率得到1-碘-2,5-二甲基-4-甲氧基苯
  参考文献：
  名称：

  用苄基三甲基二氯碘酸铵和氯化锌碘化芳醚

  摘要：

  在氯化锌存在下，在室温下，芳香醚与二氯碘酸苄基铵 (1-) 在乙酸中反应，得到碘取代的芳香醚，收率良好。

  DOI：

  10.1246/cl.1988.795

文献信息

• Iodination of Aromatic Ethers by Use of Benzyltrimethylammonium Dichloroiodate and Zinc Chloride
  作者：Shoji Kajigaeshi、Takaaki Kakinami、Masayuki Moriwaki、Masakazu Watanabe、Shizuo Fujisaki、Tsuyoshi Okamoto

  DOI：10.1246/cl.1988.795

  日期：1988.5.5

  The reaction of aromatic ethers with benzyltrimethylammonium dichloroiodate(1-) in acetic acid in the presence of zinc chloride at room temperature gave iodo-substituted aromatic ethers in good yields.

  在氯化锌存在下，在室温下，芳香醚与二氯碘酸苄基铵 (1-) 在乙酸中反应，得到碘取代的芳香醚，收率良好。
• [EN] TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF<br/>[FR] DÉRIVÉ DE TÉTRAHYDROISOQUINOLÉINE ET SON UTILISATION<br/>[ZH] 四氢异喹啉衍生物及其应用
  申请人：MEDSHINE DISCOVERY INC

  公开号：WO2022063094A1

  公开（公告）日：2022-03-31

  一系列四氢异喹啉衍生物及其晶型，具体公开了式(VII)所示化合物、其晶型及其药学上可接受的盐。
• KAJIGAESHI, SHOJI;KAKINAMI, TAKAAKI;MORIWAKI, MASAYUKI;WATANABE, MASAKAZU+, CHEM. LETT.,(1988) N 5, 795-798
  作者：KAJIGAESHI, SHOJI、KAKINAMI, TAKAAKI、MORIWAKI, MASAYUKI、WATANABE, MASAKAZU+

  DOI：——

  日期：——
• Iodination of Methylated Anisoles: Unusual Aryl Methyl Replacements and Oxidations
  作者：Charles A. Panetta、Zheng Fang、Daniell L. Mattern

  DOI：10.1021/jo00129a041

  日期：1995.12

  The treatment of methylated anisoles with iodine, periodic acid, sulfuric acid, and aqueous acetic acid has resulted in iododemethylations and/or aryl methyl oxidations in addition to the expected mono- and diiodinations of the aromatic ring. Four dimethylanisoles and o-methylanisole were treated under identical conditions. Iododemethylations were observed in three of the four dimethylanisoles and aryl methyl oxidations to benzaldehydes occurred with o-methylanisole and two of the dimethylanisoles. No precedence could be found for either of these reactions under the experimental conditions employed. Several possible mechanisms are discussed for these transformations. Some experimental evidence suggests that methyl oxidation to a benzaldehyde could be a prerequisite for an iododemethylation via an iodonium ion-assisted reverse Gatterman-Koch reaction; single-electron-transfer or classical electrophilic mechanisms are also consistent with the iododemethylations.