1-金刚烷基丙二酸 | 24779-68-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-金刚烷基丙二酸
• 中文别名: 金刚烷丙二酸
• 英文名称: 1-adamantylmalonic acid
• 英文别名: Adamantyl-(1)-malonsaeure；Adamant-1-yl-malonsaeure；1-Adamantylmalonsaeure；2-(1-adamantyl)propanedioic acid
• CAS: 24779-68-8
• 化学式: C₁₃H₁₈O₄
• mdl: MFCD00188498
• 分子量: 238.284
• InChiKey: PJDWEIFODWCDAV-UHFFFAOYSA-N

物化性质

• 熔点：
  188-192 ºC
• 密度：
  1.357

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.846
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2917190090

反应信息

• 作为反应物：
  描述：

  1-金刚烷基丙二酸 生成 Methyladamantylmalonsaeuredimethylester
  参考文献：
  名称：

  Landa; Burkhard; Vais, Collection of Czechoslovak Chemical Communications, 1973, vol. 38, # 10, p. 2947 - 2952

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(1-金刚烷酰氧基)吡啶-2-硫酮 在 氢氧化钾 、 间氯过氧苯甲酸 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 1-金刚烷基丙二酸
  参考文献：
  名称：

  由羧酸产生的碳自由基合成取代的丙二酸

  摘要：

  各种烯烃与通过Barton-酯的光解而产生的碳自由基的反应完成了适用于转化为相应丙二酸的加合物。

  DOI：

  10.1016/s0040-4039(00)60171-5

文献信息

• Novel antibacterial agents
  申请人：Christensen G. Burton

  公开号：US20070134729A1

  公开（公告）日：2007-06-14

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

  本发明涉及一种新型多结合化合物（药剂），其为抗菌剂。该发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个单价（即未连接的）配体具有与细胞壁生物合成和代谢中的酶、合成细菌细胞壁和/或细菌细胞表面的前体有结合能力，从而干扰细胞壁的合成和/或代谢。特别地，本发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个配体具有能够结合青霉素结合蛋白、横向肽酶酶、横向肽酶酶底物、β-内酰胺酶、青霉素酶、头孢菌素酶、横向转移酶酶或横向转移酶酶底物的配体结构域。优选地，配体选自β-内酰胺类或糖肽类抗菌剂。
• Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
  申请人：Garvey S. David

  公开号：US20050038029A1

  公开（公告）日：2005-02-17

  Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.

  本发明涉及一种已经被替换为氮单氧化物基团的非甾体抗炎药；包括（i）一种非甾体抗炎药，可选择性地被替换为氮单氧化物基团和（ii）一种直接捐赠、转移或释放氮单氧化物基团的化合物（优选为带电物种，尤其是亚硝酸盐）的组合物；以及使用该组合物治疗炎症、疼痛、胃肠道损伤和/或发热的方法。这些化合物和组合物可以防止非甾体抗炎药所引起的胃肠道、肾脏和其他毒性。
• Beta2-adrenergic receptor agonists
  申请人：Moran J. Edmund

  公开号：US20070179179A1

  公开（公告）日：2007-08-02

  Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.

  本发明涉及多重结合化合物，其为β2肾上腺素能受体激动剂，可用于治疗和预防哮喘、支气管炎等呼吸系统疾病。它们还可用于治疗神经系统损伤和早产。
• COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS
  申请人：GARVEY David S.

  公开号：US20080275010A1

  公开（公告）日：2008-11-06

  Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.

  本发明涉及已被替换为氮单氧化物基团的非甾体抗炎药；包括（i）非甾体抗炎药，可选择性地被替换为氮单氧化物基团和（ii）直接捐赠、转移或释放氮单氧化物基团的化合物（优选为带电物种，特别是亚硝酸盐）的组合物；以及使用这些组合物治疗炎症、疼痛、胃肠道损伤和/或发热的方法。这些化合物和组合物可以保护免受非甾体抗炎药引起的胃肠道、肾脏和其他毒性的影响。
• Muscarinic receptor antagonists
  申请人：Aggen James

  公开号：US20090306134A1

  公开（公告）日：2009-12-10

  Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.

  本发明涉及一种多结合化合物，其为肌动蛋白受体拮抗剂。该发明的多结合化合物包含2至10个配体共价连接到一个或多个连接体上。每个配体是独立的，可以是肌动蛋白受体拮抗剂或变构调节剂，但至少其中一个配体是肌动蛋白受体拮抗剂。本发明的多结合化合物在治疗和预防慢性阻塞性肺疾病、慢性支气管炎、肠易激综合征、尿失禁等疾病方面具有用途。