10-苯氧基癸基溴化物 | 2033-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 10-苯氧基癸基溴化物
• 英文名称: (10-bromo-decyl)-phenyl ether
• 英文别名: (10-Brom-decyl)-phenyl-aether；10-Brom-1-phenoxy-decan；10-Phenoxy-decylbromid；[(10-bromodecyl)oxy]-benzene；1-Bromo-10-phenoxy-decane；10-Phenoxydecyl bromide；10-bromodecoxybenzene
• CAS: 2033-87-6
• 化学式: C₁₆H₂₅BrO
• mdl: MFCD00039194
• 分子量: 313.278
• InChiKey: MOVSYEFBMVBKHT-UHFFFAOYSA-N

物化性质

• 熔点：
  31.0-31.5 °C
• 沸点：
  373.2±15.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  10-苯氧基癸基溴化物 在 氢氧化钾 、 三溴化硼 、 肼 作用下， 反应 2.0h， 生成 2-(11-Bromo-undecyl)-phenol
  参考文献：
  名称：

  Ring-closure reactions. 8. Synthesis and ultraviolet spectra of macrocyclic aromatic ethers

  摘要：

  DOI：

  10.1021/jo00437a012
• 作为产物：
  描述：

  1-[(10-bromodecyl)oxy]-4-chloro-benzene 以 甲醇 为溶剂， 反应 6.0h， 以38%的产率得到10-苯氧基癸基溴化物
  参考文献：
  名称：

  The mechanism of the photo-induced homolysis of aryl halides

  摘要：

  DOI：

  10.1016/s0040-4039(00)78642-4

文献信息

• 2,2-Dichloroalkanecarboxylic acids, processes for their production and
  申请人：Roche Diagnostics GmbH

  公开号：US05968982A1

  公开（公告）日：1999-10-19

  Pharmaceutical agents for treating diabetus mellitus which contain a compound of formula I ##STR1## as the active substance, in which A, B, A' and W have the meanings stated in the claims, new compounds of formula I as well as processes for their production.

  治疗糖尿病的药物，含有式I的化合物作为活性物质，其中A、B、A'和W具有索要权利要求书中所述的含义，以及式I的新化合物以及其生产方法。
• Encapsulating propeller-like columnar liquid crystals with an aromatic outer shell: influence of phenoxy-terminated side chains on the phase behaviour of triphenylbenzenes
  作者：Korinna Bader、Tobias Wöhrle、Esra Öztürk、Angelika Baro、Sabine Laschat

  DOI：10.1039/c8sm00590g

  日期：——

  temperatures of columnar liquid crystals by side chain variation is often associated with an undesired change in the mesophase type and/or geometry. To overcome this problem phenoxy-terminated side chains rather than alkyl side chains were grafted onto triphenylbenzenes, which resulted in reduced clearing points, while melting points were little affected. More importantly, helical columnar self-assembly was not

  通过侧链变化来调节柱状液晶的相变温度通常与中间相类型和/或几何形状的不期望的变化有关。为了克服这个问题，将苯氧基封端的侧链而不是烷基侧链接枝到三苯苯上，这导致清除点降低，而熔点几乎不受影响。更重要的是，螺旋圆柱状的自组装没有受到损害。
• ω-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents
  作者：Kirstin Meyer、Edgar Voss、Richard Neidlein、Hans-Frieder Kühnle、Johannes Pill

  DOI：10.1016/s0223-5234(99)80029-4

  日期：1998.10

  In screening experiments certain omega-substituted alkyl carboxylic acids were found to produce an increase in insulin-stimulated C-14-acetate incorporation into triglycerides, which may indicate an improvement in the action of insulin. Antidiabetic and lipid-lowering properties in genetically diabetic ob/ob mice demonstrated the in vivo relevance of the insulin-potentiating effects seen in vitro. The chemical structures of the w-substituted alkyl carboxylic acids with insulin-potentiating effects correspond to the general formula ring-spacer-COOH. A close structure-activity relationship was observed. The most potent compound in ob/ob mice was 3e, which normalized blood glucose as well as hyperinsulinaemia and lowered serum triglycerides and cholesterol by 52% and 37%, respectively. On the basis of these results, omega-substituted alkyl carboxylic acids are interesting as a new class of oral antidiabetic agents with insulin-sensitizing and lipid-lowering activity. (C) Elsevier, Paris.
• v. Braun; Kamp, Chemische Berichte, 1937, vol. 70, p. 973,975
  作者：v. Braun、Kamp

  DOI：——

  日期：——
• Synthesis and Pharmacological Study of New Piperazine Derivatives. III. Phenoxyalkylpiperazines
  作者：R. Ratouis、J. R. Boissier、C. Dumont

  DOI：10.1021/jm00326a035

  日期：1965.3