1H-吡唑-1-乙酰胺,4,5-二苯基-N-[2-(1-吡咯烷基)乙基]- | 120982-50-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1H-吡唑-1-乙酰胺,4,5-二苯基-N-[2-(1-吡咯烷基)乙基]-
• 英文名称: 4,5-Diphenyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrazole-1-acetamide
• 英文别名: 2-(4,5-diphenylpyrazol-1-yl)-N-(2-pyrrolidin-1-ylethyl)acetamide
• CAS: 120982-50-5
• 化学式: C₂₃H₂₆N₄O
• 分子量: 374.486
• InChiKey: JJIRUKMRYQYMCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl 4,5-diphenyl-1H-pyrazole-1-acetate 生成 1H-吡唑-1-乙酰胺,4,5-二苯基-N-[2-(1-吡咯烷基)乙基]-
  参考文献：
  名称：

  BAILEY, DENIS M.

  摘要：

  DOI：

文献信息

• 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use
  申请人：Sterling Drug Inc.

  公开号：US04916150A1

  公开（公告）日：1990-04-10

  N-[alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

  用于治疗哺乳动物心律失常的N-[烷基氨基)烷基]-3,4（或4,5）-二芳基-1H-吡唑-1-(支链)酰胺和吡唑-1-烷基胺，可通过将吡唑-1-乙酸较低烷基酯与适当的二胺反应后还原或通过将吡唑-1-乙酸较低烷基酯的阴离子与烷基化剂反应后，再用适当的胺取代酯而制备。
• 1H-pyrazole-1-(branched)alkanamides as antiarrhythmic agents,
  申请人：Sterling Drug Inc.

  公开号：US04988725A1

  公开（公告）日：1991-01-29

  N-[(alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

  用于治疗哺乳动物心律失常的N-[(烷基)氨基烷基]-3,4或4,5-二芳基-1H-吡唑-1-(支链)烷酰胺和吡唑-1-烷胺，通过将吡唑-1-乙酸较低烷基酯与适当的二胺反应后还原或通过将较低烷基吡唑-1-乙酸酯的阴离子与烷基化试剂反应后，再用适当的胺取代酯来制备。
• 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use
  申请人：Sterling Drug, Inc.

  公开号：US04870095A1

  公开（公告）日：1989-09-26

  N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an .omega.-aminoalkanol, followed by activation of the alcohol and displacement by an appropriate amine.

  用于治疗哺乳动物心律失常的N-[(二取代氨基)烷基]-3,4(或4,5)-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺是通过将吡唑-1-乙酸或丙酸的较低烷基酯与适当的二胺反应或将吡唑-1-乙酸或丙酸的较低烷基酯与.omega.-氨基烷醇反应，随后激活醇并被适当的胺替换而制备的。
• N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmic
  申请人：Sterling Drug Inc.

  公开号：US04898880A1

  公开（公告）日：1990-02-06

  N-[(heterocycle)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl) amine or by reacting a pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl)amine.

  N-[(杂环)烷基]-3,4（或4,5）-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺可用于治疗哺乳动物的心律失常，其制备方法是将吡唑-1-乙酸或丙酸的较低烷基酯与适当的（杂环烷基）胺反应，或将吡唑-1-乙酸或丙酸与适当的（杂环烷基）胺反应。
• 1H-pyrazole-1-alkanamides and preparation useful as antiarrhythmic agents
  申请人：STERLING DRUG INC.

  公开号：EP0299407A1

  公开（公告）日：1989-01-18

  N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-­1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester or pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an ω-­aminoalkanol, followed by activation of the alcohol and displacement of an appropriate amine.

  N-[(二取代氨基)烷基]-3,4(或 4,5)-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺，可用于治疗哺乳动物的心律失常、其制备方法是将吡唑-1-乙酸或丙酸的低级烷基酯与适当的二胺反应，或将吡唑-1-乙酸或丙酸的低级烷基酯与ω-氨基醇反应，然后使醇活化并置换适当的胺。