2 -吡啶二硫代氨基甲酸乙酯 | 13037-05-3

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2 -吡啶二硫代氨基甲酸乙酯
• 中文别名: 2-吡啶二硫代氨基甲酸乙酯
• 英文名称: Ethyl-2-aminopyridyldithiocarbamat
• 英文别名: [2]pyridyl-dithiocarbamic acid ethyl ester；[2]Pyridyl-dithiocarbamidsaeure-aethylester；ethyl pyridin-2-yldithiocarbamate；ethyl 2-pyridyldithiocarbamate；ethyl N-pyridin-2-ylcarbamodithioate
• CAS: 13037-05-3
• 化学式: C₈H₁₀N₂S₂
• mdl: MFCD00059104
• 分子量: 198.313
• InChiKey: ZCXHKAIAVJUBPJ-UHFFFAOYSA-N

物化性质

• 熔点：
  62°C
• 沸点：
  316.7±34.0 °C(Predicted)
• 密度：
  1.287±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  82.3
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  2 -吡啶二硫代氨基甲酸乙酯 、 N-叔丁氧羰基-1,4-丁二胺 在 hexane-diethyl ether 作用下， 以to give the title compound (2.78 g)的产率得到t-Butyl 4-{[(2-pyridylamino)carbothioyl]amino}butylcarbamate
  参考文献：
  名称：

  Five-membered-ring compound

  摘要：

  公式为：其中X为氧或硫，R1为氢，取代或未取代的烷基等，R2为氢，取代或未取代的烷基，取代或未取代的芳基等，Y1为直接键，取代或未取代的烷基，-CO(CH2)n-等，波浪线表示(E)-构型或(Z)-构型，R3为取代或未取代的芳基等，Y2为取代或未取代的烷基等，R4为氢，取代或未取代的脂肪酰基，取代或未取代的烷基等，R5为氢等，或其盐。这些化合物能够抑制嗜酸性粒细胞和淋巴细胞等白细胞的浸润，因此对于治疗各种炎症是有用的。

  公开号：

  US06919361B2
• 作为产物：
  描述：

  溴乙烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 作用下， 生成 2 -吡啶二硫代氨基甲酸乙酯
  参考文献：
  名称：

  326.杂环基-罗丹宁和-2-硫代乙内酰脲

  摘要：

  DOI：

  10.1039/jr9560001644

文献信息

• Five-membered-ring compound
  申请人：——

  公开号：US20040072827A1

  公开（公告）日：2004-04-15

  A 5-membered cyclic compound of the formula: 1 wherein X is oxygen or sulfur, R 1 is hydrogen, substituted or unsubstituted alkyl, etc., R 2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y 1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH 2 ) n —, etc., the wavy line means (E)-configuration or (Z)-configuration, R 3 is substituted or unsubstituted aryl, etc., Y 2 is substituted or unsubstituted alkylene, etc., R 4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R 5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.

  公式为1的五元环化合物，其中X是氧或硫，R1是氢，取代或未取代的烷基等，R2是氢，取代或未取代的烷基，取代或未取代的芳基等，Y1是直接键，取代或未取代的烷基，-CO(CH2)n-等，波浪线表示（E）构型或（Z）构型，R3是取代或未取代的芳基等，Y2是取代或未取代的烷基等，R4是氢，取代或未取代的脂肪酰基，取代或未取代的烷基等，R5是氢等，或其盐，这些化合物能够抑制白细胞浸润，如嗜酸性粒细胞和淋巴细胞，从而有助于治疗各种炎症。
• IDO Inhibitors
  申请人：Mautino Mario

  公开号：US20110053941A1

  公开（公告）日：2011-03-03

  Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

  目前提供以下方法：(a) 通过接触本文中描述的化合物的调节有效量与吲哚胺2,3-二氧化酶相互作用，从而调节吲哚胺2,3-二氧化酶的活性；(b) 治疗需要吲哚胺2,3-二氧化酶(IDO)介导的免疫抑制的患者，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(c) 治疗需要抑制吲哚胺-2,3-二氧化酶酶活性的医疗状况，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(d) 增强抗癌治疗的有效性，包括给予抗癌剂和本文中描述的化合物；(e) 治疗与癌症相关的肿瘤特异性免疫抑制，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(f) 治疗与传染病相关的免疫抑制，例如HIV-1感染，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量。
• FIVE-MEMBERED-RING COMPOUND
  申请人：Sumitomo Pharmaceuticals Company, Limited

  公开号：EP1300401A1

  公开（公告）日：2003-04-09

  A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, -CO(CH2)n-, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.

  式中的五元环状化合物： 其中X为氧或硫，R1为氢、取代或未取代的烷基等，R2为氢、取代或未取代的烷基、取代或未取代的芳基等，Y1为直接键、取代或未取代的亚烷基、-CO(CH2)n-等，波浪线表示(E)-构型或(Z)-构型，R3为取代或未取代的芳基等、Y2 是取代或未取代的亚烷基等，R4 是氢、取代或未取代的烷酰基、取代或未取代的烷基等，R5 是氢等，或它们的盐，这些化合物能够抑制嗜酸性粒细胞和淋巴细胞等白细胞的浸润，可用于治疗各种炎症。
• 2-imino-thiazolidine and -oxazolidine derivatives for use as antiinflammatory agents
  申请人：Dainippon Sumitomo Pharma Co., Ltd.

  公开号：EP1669070A2

  公开（公告）日：2006-06-14

  A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur,R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, -CO(CH2)n-, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.

  式中的 5 元环状化合物： 其中X为氧或硫，R1为氢、取代或未取代的烷基等，R2为氢、取代或未取代的烷基、取代或未取代的芳基等，Y1为直接键、取代或未取代的亚烷基、-CO(CH2)n-等，波浪线表示(E)-构型或(Z)-构型，R3为取代或未取代的芳基等、Y2 是取代或未取代的亚烷基等，R4 是氢、取代或未取代的烷酰基、取代或未取代的烷基等，R5 是氢等，或它们的盐，这些化合物能够抑制嗜酸性粒细胞和淋巴细胞等白细胞的浸润，可用于治疗各种炎症。
• Cured film formed by curing photosensitive resin composition and method for manufacturing same
  申请人：TORAY INDUSTRIES, INC.

  公开号：US10545406B2

  公开（公告）日：2020-01-28

  Provided is a cured film of high elongation, low stress, and high adhesion to metal copper. The cured film is formed by curing a photosensitive resin composition, wherein the photosensitive resin comprises a polyhydroxyamide, and wherein the rate of ring-closure of the polyhydroxyamide in the cured film is not more than 10%.

  本发明提供了一种对金属铜具有高延伸率、低应力和高附着力的固化薄膜。该固化膜是通过固化感光树脂组合物形成的，其中感光树脂包括聚羟酰胺，固化膜中聚羟酰胺的环闭率不超过 10%。