Synthesis and physico-chemical properties of ionic liquids—3-methyl-1-alkyloxycarbonylmethylpyridinium hexafluorophosphates
摘要:
Ionic liquids based on 1-alkyloxycarbonylmethyl-3-methylpyridinium and Cl- and PF6- anions have been synthesized. The conductivity of their solutions in acetonitrile and the thermal stability over 25-500 degrees C in air have been determined.
Derivatives of 2-[3-(3-indoly)2-amino propionyloxy] acetic acid, and
申请人:Laboratoires Panmedica
公开号:US04456611A1
公开(公告)日:1984-06-26
Derivatives of 2-[3-(3-indolyl 2-amino propionyloxy] acetic acid corresponding to the following general formula I: ##STR1## in which R represents a hydrogen atom, a linear or branched alkyl radical including 1 to 12 carbon atoms, or a mono-alicyclic or polycyclic radical containing 5 to 16 carbon atoms, possibly linked by a methylene radical, and their pharmaceutically acceptable addition salts, are useful as medicaments for palliating deficiency of the serotoninergic system.
PROCESS FOR PREPARING PYRIDINE-2,3-DICARBOXYLIC ACID COMPOUNDS
申请人:SUGAI CHEMICAL INDUSTRY CO., LTD.
公开号:EP0357792A1
公开(公告)日:1990-03-14
A pyridine-2,3-dicarboxylic acid compound represented by general formula (I) (wherein R' and R2 may be the same or different and each represents a lower alkyl group, and R3 represents a hydrogen atom or a lower alkyl group) is prepared by reacting an alkali metal salt of oxalacetic acid diester with an acid and a halogenating agent or reacting an oxalic acid diester with a haloacetic acid ester to obtain an α-halooxalacetic acid diester, and reacting the formed diester with a 2-propenal compound and ammonia. The obtained compounds are useful as intermediates for agricultural chemicals and medicines.
Process for preparing pyridine-2,3-dicarboxylic acid compounds
申请人:SUGAI CHEMICAL INDUSTRY CO., LTD.
公开号:EP0588372A1
公开(公告)日:1994-03-23
A process for preparing pyridine-2,3-dicarboxylic acid compounds of the following formula, which comprises preparing α-halo-oxalacetic acid diesters by reacting oxalacetic acid diester alkali metallic salts with an acid and a halogenating agent or by reacting oxalic acid diesters with halo-acetic acid esters, and then reacting the obtained α-halo-oxalacetic acid diesters with 2-propenal compounds and ammonia.
wherein R¹ and R² are, identical or different, a lower alkyl group, and R³ is a hydrogen atom or a lower alkyl group.
The pyridine-2,3-dicarboxylic acid compounds obtained by the process of the invention are useful as an intermediate for manufacturing agricultural chemicals and pharmaceuticals.