2,2'-(1,2-亚苯基)二(5-苯基-1,3-恶唑) | 29863-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2,2'-(1,2-亚苯基)二(5-苯基-1,3-恶唑)
• 英文名称: 2,2'-(Phenylene)bis(5-phenyloxazole)
• 英文别名: 5-phenyl-2-[2-(5-phenyl-1,3-oxazol-2-yl)phenyl]-1,3-oxazole
• CAS: 29863-19-2
• 化学式: C₂₄H₁₆N₂O₂
• 分子量: 364.4
• InChiKey: GGBOVJMCGIHGCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• OLIGONUCLEOTIDE DECOYS AND METHODS OF USE
  申请人：Jones Walter Keith

  公开号：US20090099108A1

  公开（公告）日：2009-04-16

  The present invention describes reagents and methods for using a concatemerized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end repeated copies of a short (more than 5, 10, 15, 20, 2, 3035, 40, 45, 50, 75, 100, or more by but generally less than about 3 kb) dsDNA containing a sequence or sequences that act as transcription factor decoys. The present invention also provides for the use of the polymers for CODN/polymer complexes to a specific cell type; thus the agent can be made organ, tissue and/or cell-type specific. In another embodiment, the present invention provides for use of the CODN's in vitro or in vivo, in isolated cells or intact animals in which specific blockade of transcription factors or delivery of DNA or other biological effector is desirable. In one embodiment, this includes use as a research tool, including studies of specific genes and studies to identify specific genes regulated by the transcription factors targeted. In another embodiment, the present invention provides for using polyamides for NF-kB-specific CODN delivery in the treatment of myocardial ischemia/reperfusion and myocardial infarction, heart failure and hypertrophy, cardioprotection, stroke, neuroprotection, sepsis, arthritis, asthma, heritable inflammatory disorders, cancer, heritable immune dysfunctions, inflammatory processes, whether caused by disease or injury or infection, oxidative stress to any organ whether caused by disease, surgery or injury. The decoys may be any transcription factors, including, but not limited to, NF-kB, AP-I, ATF2, ATF3, SP 1 and others.

  本发明描述了一种使用串联双链寡核苷酸分子（CODN）作为转录因子诱饵的试剂和方法。在一种实施例中，串联体由一种短的（大于5、10、15、20、25、30、35、40、45、50、75、100或更多，但通常小于约3 kb）双链DNA的端对端重复拷贝构成，其中包含作为转录因子诱饵的一个或多个序列。本发明还提供了将聚合物用于CODN/聚合物复合物对特定细胞类型的使用；因此，该试剂可以被制成特定的器官、组织和/或细胞类型。在另一种实施例中，本发明提供了在离体或体内、在孤立的细胞或完整的动物中使用CODN的方法，其中需要特定的转录因子阻断或DNA或其他生物效应物的递送。在一种实施例中，这包括用作研究工具，包括研究特定基因和研究识别被靶向的转录因子调控的特定基因。在另一种实施例中，本发明提供了使用聚酰胺进行NF-kB特异性CODN递送，用于治疗心肌缺血/再灌注和心肌梗死、心力衰竭和肥厚、心脏保护、中风、神经保护、败血症、关节炎、哮喘、遗传性炎症性疾病、癌症、遗传性免疫功能障碍、炎症过程，无论是由疾病、手术还是损伤或感染引起的，以及对任何器官的氧化应激。诱饵可以是任何转录因子，包括但不限于NF-kB、AP-I、ATF2、ATF3、SP1等。
• REAGENTS FOR LABELLING NUCLEIC ACIDS AND USES THEREOF
  申请人：Mouritzen Peter

  公开号：US20090023594A1

  公开（公告）日：2009-01-22

  The present invention relates to labelling kits containing novel non-natural nucleotide monomers and to methods of making and using such compounds. The invention further relates to a method of detecting the presence of a nucleic acid, e.g., RNA, of interest in a sample, the method having the following steps: providing the sample; ligating a nucleic acid of interest with a labelling reagent according to the instant invention; providing a nucleic acid array having probes directed to the nucleic acid of interest; hybridizing the labelled nucleic acid fragments to said nucleic acid array; and determining the extent of hybridization to said probes to determine the presence of the nucleic acid of interest.

  本发明涉及包含新型非自然核苷酸单体的标记试剂盒以及制备和使用这些化合物的方法。本发明还涉及一种检测样品中感兴趣的核酸（例如RNA）存在的方法，该方法包括以下步骤：提供样品；使用本发明的标记试剂将感兴趣的核酸连接起来；提供具有针对感兴趣的核酸的探针的核酸阵列；将标记的核酸片段杂交到该核酸阵列上；并确定杂交到探针的程度以确定感兴趣的核酸是否存在。
• DNA sequencing using multiple flourescent labels being distinguishable by their decay times
  申请人：Caliper Technologies Corp.

  公开号：US20030036080A1

  公开（公告）日：2003-02-20

  A method is provided for identifying components of a mixture by labeling the individual components with fluorescent agents having different fluorescence lifetimes. The components are subsequently separated, fluorescent labels detected and their lifetimes measured. Based on the measured fluorescent lifetimes, the components of mixtures of small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified.

  本发明提供了一种方法，通过用具有不同荧光寿命的荧光剂标记混合物中的各个组分来识别混合物的组分。随后分离各组分，检测荧光标签并测量其寿命。根据测得的荧光寿命，可以识别小分子有机物、聚合物、肽、糖和核酸混合物的成分。
• Rational syntheses of heteroleptic lanthanide sandwich coordination complexes
  申请人：——

  公开号：US20030092896A1

  公开（公告）日：2003-05-15

  A half-sandwich coordination complex, useful for the synthesis of triple-decker sandwich coordination compounds, is produced by reacting a precursor complex of the formula XM(R 1 ) 2 wherein X is a halogen, M is a metal, and R 1 is an amide, with a free base porphyrinic macrocycle to produce said half-sandwich complex. The half-sandwich coordination complex can be used to make a triple-decker sandwich coordination compound by reacting a half-sandwich coordination complex as described above with a double-decker sandwich coordination compound.

  半夹层配位复合物可用于合成三层夹层配位化合物，其制备方法是将式 XM（R 1 ) 2 其中 X 是卤素，M 是金属，R 1 是酰胺，与游离基卟啉大环反应生成所述半三明治配合物。将上述半三明治配位络合物与双层三明治配位化合物反应，可制成三层三明治配位化合物。
• Cellular delivery and activation of polypeptide-nucleic acid complexes
  申请人：——

  公开号：US20040176282A1

  公开（公告）日：2004-09-09

  In general, the present invention provides compositions for the cellular delivery of nucleic acids, polypeptides and/or flourophores, molecular complexes comprising fluorescent molecules or moieties, nucleic acids and polypeptides, and methods of making and using such compositions. Light-activated dispersal of the complexes leads to the intracellular release of one or more nucleic acids and/or peptides from the compositions or complexes. The biological activities of nucleic acids, polypeptides and flourophores may be repressed within the complexes, and these activities are restored upon release from the complexes.

  一般来说，本发明提供了用于细胞递送核酸、多肽和/或荧光团的组合物，包含荧光分子或分子、核酸和多肽的分子复合物，以及制造和使用此类组合物的方法。复合物在光的作用下分散，导致一种或多种核酸和/或多肽从组合物或复合物中释放到细胞内。核酸、多肽和萤光素的生物活性可能会在复合物中受到抑制，而从复合物中释放出来后，这些活性又会恢复。