2,2,2-三氯乙基苯基(甲苯磺酰基)氨基甲酸酯 | 1016226-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,2,2-三氯乙基苯基(甲苯磺酰基)氨基甲酸酯
• 英文名称: 2,2,2-trichloroethyl N-(4-methylphenyl)sulfonyl-N-phenylcarbamate
• CAS: 1016226-22-4
• 化学式: C₁₆H₁₄Cl₃NO₄S
• 分子量: 422.716
• InChiKey: IAIBNPZVTWYMFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2,2-三氯乙基苯基(甲苯磺酰基)氨基甲酸酯 在 三甲基氯硅烷 、 mischmetal 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 3.08h， 以54%的产率得到对甲苯硫酰苯胺
  参考文献：
  名称：

  Mild Approach to the Deprotection of Troc from Protected Amines Using Mischmetal and TMSCl

  摘要：

  The 2,2,2-trichloroethoxycarbonyl (Troc) protecting group was efficiently removed from Troc-protected aliphatic and aromatic amines and also some Troc, Tos- and Troc, Ac-protected amines using activated mischmetal (MM). All reactions were performed by refluxing in dry tetrahydrofuran under an argon atmosphere and gave moderate to excellent yields. Several new compounds were synthesized, and new data about reactivity of Troc group were obtained.

  DOI：

  10.1080/00397910903419910

文献信息

• Mild Approach to the Deprotection of Troc from Protected Amines Using Mischmetal and TMSCl
  作者：Eerold Vellemäe、Vladimir Stepanov、Uno Mäeorg

  DOI：10.1080/00397910903419910

  日期：2010.10.20

  The 2,2,2-trichloroethoxycarbonyl (Troc) protecting group was efficiently removed from Troc-protected aliphatic and aromatic amines and also some Troc, Tos- and Troc, Ac-protected amines using activated mischmetal (MM). All reactions were performed by refluxing in dry tetrahydrofuran under an argon atmosphere and gave moderate to excellent yields. Several new compounds were synthesized, and new data about reactivity of Troc group were obtained.