2,3,4,5,6-五甲基吡啶 | 3748-83-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,3,4,5,6-五甲基吡啶
• 英文名称: pentamethylpyridine
• 英文别名: 2,3,4,5,6-pentamethyl pyridine；2,3,4,5,6-pentamethylpyridine；2,3,4,5,6-Pentamethylpyridin；pentamethyl-pyridine；Pentamethyl-pyridin；Pentamethylpyridin
• CAS: 3748-83-2
• 化学式: C₁₀H₁₅N
• mdl: MFCD11044381
• 分子量: 149.236
• InChiKey: LFURNOQUNVHWHY-UHFFFAOYSA-N

物化性质

• 熔点：
  49-51 °C
• 沸点：
  99-100 °C(Press: 10 Torr)
• 密度：
  0.909±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  2,3,4,5,6-五甲基吡啶 在 双氧水 、 溶剂黄146 作用下， 生成 五甲基吡啶-1-氧化物
  参考文献：
  名称：

  Shindo, Pharmaceutical Bulletin, 1956, vol. 4, p. 460,469

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 palladium on activated charcoal 、 Lindlar's catalyst 、 乙醇 作用下， 生成 2,3,4,5,6-五甲基吡啶
  参考文献：
  名称：

  五甲基吡啶

  摘要：

  本来文描述了以前未知的五甲基吡啶。对他的代表是象征。用LiAlH 4还原的3,5-二羧酸可力丁乙酯为3,5-二氧甲基-2,4,6-三甲基吡啶，将其转化为3,5-二氯甲基-2,4,6-三甲基吡啶和在后者中，还原性地除去了两个氯原子。

  DOI：

  10.1002/hlca.19510340705
• 作为试剂：
  描述：

  N-(N-((苯甲酰氧基)羰基)-L-苯丙氨酰)-L-缬氨酸 、 L-丙氨酸甲酯盐酸盐 在 2,3,4,5,6-五甲基吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Cbz-Phe-D-Val-Ala-OMe 、 Z-L-Phe-L-Val-L-Ala-OMe
  参考文献：
  名称：

  Peptide Coupling in the Presence of Highly Hindered Tertiary Amines

  摘要：

  Previously, 2,4,6-trimethylpyridine (collidine), due to steric shielding around the N-atom, was found to be an efficient base for effecting peptide segment coupling via azabenzotriazole-based onium-style coupling reagents. A number of even more highly hindered bases, including 2,3,5,6-tetramethylpyridine , 2, 6-di-tert-butyl-4-(dimethylamino)pyridine, triisopropylamine, and N-tert-butylmorpholine, have been compared with collidine in such reactions. Some of the newer bases showed advantages in terms of convenience in handling and maintenance of configuration during segment coupling processes, although dramatic differences based on steric effects were not observed. On the basis of results with a number of test peptides and many base-coupling reagent combinations, it was noted that most efficient results are obtained if 1 equiv of HOAt is present as an additive during the coupling process. For rapid activation of onium-style coupling reagents during stepwise solid-phase coupling reactions, the stronger base 2,6-di-tert-butyl-4-(dimethylamino)pyridine was more effective than collidine.

  DOI：

  10.1021/jo950912x

文献信息

• ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
  申请人：UNIVERSAL DISPLAY CORPORATION

  公开号：US20200369699A1

  公开（公告）日：2020-11-26

  Provided is a compound comprising a first ligand L A of

  提供一个包含第一配体L的化合物。
• FUNGICIDAL OR BACTERICIDAL COMPOSITION, AND METHOD FOR CONTROLLING DISEASES
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20170188580A1

  公开（公告）日：2017-07-06

  To provide a novel pesticidal composition, particularly a composition for a fungicide. A fungicidal or bactericidal composition comprising one or more compounds selected from oxime-substituted amide compounds represented by the formula (I), or their N-oxides or salts, and one or more compounds selected from known fungicidal or bactericidal compounds: wherein G 1 represents a structure of G 1 -1, G 1 -27, etc., G 2 represents a structure of G 2 -2, etc., W represents an oxygen atom, etc., X 1 represents difluoromethyl, trifluoromethyl, etc., X 2 , X 3 , X 4 and X 5 each independently represents a hydrogen atom, etc., Y 1 represents a halogen atom, etc., Y 2 represents a hydrogen atom, a halogen atom, etc., Y 3 represents a halogen atom, trifluoromethyl, C 2 -C 6 alkynyl, etc., Y 4 represents a hydrogen atom, etc., R 1 represents C 1 -C 6 alkyl, C 1 -C 4 haloalkyl, etc., R 2 and R 3 each independently represents a hydrogen atom, methyl, etc., R 4 represents a hydrogen atom, etc., and R 5 represents methyl, etc.

  提供一种新型杀虫剂组合物，特别是一种用于杀菌剂的组合物。一种杀真菌或杀菌组合物，包括下式所示的氧肟取代酰胺化合物中选择的一个或多个化合物，或其N-氧化物或盐，以及从已知的杀真菌或杀菌化合物中选择的一个或多个化合物： 其中G1代表G1-1、G1-27等的结构，G2代表G2-2等的结构，W代表氧原子等，X1代表二氟甲基、三氟甲基等，X2、X3、X4和X5分别独立地代表氢原子等，Y1代表卤素原子等，Y2代表氢原子、卤素原子等，Y3代表卤素原子、三氟甲基、C2-C6炔基等，Y4代表氢原子等，R1代表C1-C6烷基、C1-C4卤代烷基等，R2和R3分别独立地代表氢原子、甲基等，R4代表氢原子等，R5代表甲基等。
• Gear effect—10
  作者：Christian Roussel、Alexandru T. Balaban、Ulf Berg、Michel Chanon、Roger Gallo、Gerd Klatte、Joseph A. Memiaghe、Jacques Metzger、Daniela Oniciu、Johanna Pierrot-Sanders

  DOI：10.1016/s0040-4020(01)88642-7

  日期：1983.1

  The effect of the shape of a methyl group on reactivity, which cannot be accounted for by considering a methyl group as a spherical substituent with the appropriate van der Waals radius, was considered in kinetics of alkylalion of substituted pyridines and barriers to rotation and ground state conformations of an isopropyl group attached to a planar framework. The perturbation of a methyl group by an

  在取代吡啶的烷基化动力学以及旋转和基态壁垒中考虑了甲基形状对反应性的影响，这不能通过考虑将甲基作为具有适当范德华半径的球形取代基来解决。附着在平面骨架上的异丙基构象。甲基被邻甲基干扰是由独特的构象解释引起的，该构象解释涉及甲基的多面体形状。
• POLYMERIZATION INITIATOR, MODIFIED-CONJUGATED DIENE POLYMER AND TIRE PRODUCED THEREFROM
  申请人：LG CHEM, LTD.

  公开号：US20140163163A1

  公开（公告）日：2014-06-12

  The present disclosure relates to a polymerization initiator and a modified conjugated diene polymer prepared using the same, and more particularly to a polymerization initiator which is a compound represented by the following formula 1, and a modified conjugated diene polymer prepared using the same: wherein R 1 to R 5 are each independently hydrogen or a C 1-10 alkylgroup or its carbanion; n− represents the number of negative charges of the carbanion and is 1− to 5−; M is a metal; and n is equal to the number of carbanions in R 1 to R 5 .

  本公开涉及一种聚合引发剂以及使用该聚合引发剂制备的改性共轭二烯聚合物，更具体地说，是一种由以下公式1所示的化合物组成的聚合引发剂，以及使用其制备的改性共轭二烯聚合物： 其中R1至R5各自独立地为氢或C1-10烷基或其碳负离子；n-代表碳负离子的负电荷数，为1-至5-；M是一种金属；n等于R1至R5中碳负离子的数量。
• Syntheses and Properties of<i>N</i>-Fluoropyridinium Salts
  作者：Teruo Umemoto、Kikuko Harasawa、Ginjiro Tomizawa、Kosuke Kawada、Kyoichi Tomita

  DOI：10.1246/bcsj.64.1081

  日期：1991.4

  counter anion displacement reactions of unstable pyridine-F2 compounds, fluorination of salts of pyridines with protonic acids or silyl esters with F2, and/ or fluorination of Lewis acid complexes of pyridines. The scope of each method was examined in detail. Each of the N-fluoropyridinium salts was assigned as the first stable 1 : 1 salt structure of the pyridine nucleus and halogen atom on the basis

  各种稳定的 N-氟吡啶鎓盐，带有非亲核性或弱亲核性抗衡阴离子，例如 TfO−、FSO3−、BF4−、SbF6−、ClO4−、CH3SO3− 等，或带有给电子或吸电子取代基合成了吡啶环上的化合物并研究了它们的性质。还合成了 N-氟吡啶鎓-2-磺酸盐、N-氟喹啉鎓三氟甲磺酸盐和高度受阻的 N-氟-2,6-二-叔丁基吡啶鎓盐。它们是通过不稳定的吡啶-F2 化合物的抗衡阴离子置换反应、吡啶盐与质子酸或甲硅烷基酯与 F2 的氟化和/或吡啶的路易斯酸络合物的氟化来合成的。详细检查了每种方法的范围。每种 N-氟吡啶鎓盐都被指定为第一个稳定的 1：1 基于光谱和元素分析的吡啶核和卤素原子的盐结构。稳定性取决于抗衡阴离子的亲核性或碱性以及环的电子性质或位置...