2,3,4,6-四-O-乙酰基-1,5-脱水-D-甘露醇 | 13121-61-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2,3,4,6-四-O-乙酰基-1,5-脱水-D-甘露醇
• 英文名称: 2,3,4,6-Tetra-O-acetyl-1,5-Anhydro-D-mannitol
• 英文别名: (3,4,5-triacetyloxyoxan-2-yl)methyl acetate
• CAS: 13121-61-4
• 化学式: C₁₄H₂₀O₉
• 分子量: 332.3
• InChiKey: ULWHEXUWXLOVPV-UHFFFAOYSA-N

物化性质

• 熔点：
  104-105 °C
• 沸点：
  383.3±35.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于二氯甲烷、乙酸乙酯
• 保留指数：
  1885.42

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• [EN] METHOD OF PREPARATION OF NOVEL NUCLEOSIDE ANALOGS AND USES<br/>[FR] PROCEDE POUR PREPARER DE NOUVEAUX ANALOGUES DE NUCLEOSIDE, ET LEURS UTILISATIONS
  申请人：AUSPEX PHARMACEUTICALS INC

  公开号：WO2005049582A1

  公开（公告）日：2005-06-02

  Processes for the preparation of racemic and optically active nucleoside analogs of formula (A) are described. These compounds are useful as anti-infective agents, antisense therapeutic agents and hybridization assay probes.

  描述了制备式(A)的外消旋和光学活性核苷类似物的过程。这些化合物可用作抗感染剂、反义治疗剂和杂交分析探针。
• Method of preparation of novel nucleoside analogs and uses
  申请人：Tse Bruno

  公开号：US20110070192A1

  公开（公告）日：2011-03-24

  Processes for the preparation of racemic and optically active nucleoside analogs of formula (A) are described. These compounds are useful as anti-infective agents, antisense therapeutic agents and hybridization assay probes.

  本文描述了制备式（A）的外消旋和光学活性核苷类似物的过程。这些化合物可用作抗感染剂，反义治疗剂和杂交检测探针。
• METHOD OF PREPARATION OF 6-AZIDO-2,4-DIACETAMIDO-2,4,6-TRIDEOXY-D-MANNOSE
  申请人：Centre National de la Recherche Scientifique

  公开号：EP3170832A1

  公开（公告）日：2017-05-24

  The invention relates to a method of preparation of 6-azido-2,4-diacetamido-2,4,6-trideoxy-D-mannose. This method comprises the chemical reaction of compound of formula X: Wherein: R1 can be a C1 to C6 alkyl including methyl, ethyl, isopropyl; aryl including phenyl; each of these groups being substituted or not; and R2 can be a C1 to C6 alkyl including methyl, ethyl, isopropyl, tert-butyl, isobutyl; each of these groups being substituted or not; with a deprotecting reagent comprising a Lewis or Brönsted acid in a polar aprotic solvent, thereby obtaining a free C-1 OH group. The method can also start with the preparation from commercially available D-galactose pentaacetate, D-galactose tetraacetate or tetraacetyl D-galactosyl trichloroacetimidate. According to the invention the step of deprotecting the anomeric position avoids the use of cerium and allows the easy purification of 6-azido-2,4-diacetamido-2,4,6-trideoxy-D-mannose.

  本发明涉及一种制备 6-叠氮-2,4-二乙酰氨基-2,4,6-三脱氧-D-甘露糖的方法。 该方法包括式 X 的化合物的化学反应： 其中 R1 可以是包括甲基、乙基、异丙基在内的 C1 至 C6 烷基；包括苯基在内的芳基；这些基团中的每个基团均可被取代或未被取代； R2 可以是 C1 至 C6 烷基，包括甲基、乙基、异丙基、叔丁基、异丁基；每个基团均被取代或未被取代； 在极性钝化溶剂中，用由路易斯酸或勃氏酸组成的脱保护试剂，从而获得游离的 C-1 OH 基团。 该方法也可以从市售的 D-半乳糖五乙酸酯、D-半乳糖四乙酸酯或 D-半乳糖基三氯乙酸亚氨酸四乙酸酯开始制备。 根据本发明，去保护同分异构体位置的步骤避免了铈的使用，并使 6-叠氮-2,4-二乙酰氨基-2,4,6-三脱氧-D-甘露糖易于纯化。
• Fluorinating agent
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US10479681B2

  公开（公告）日：2019-11-19

  An object of the present invention is to provide a novel substance that has a high reactivity as a fluorinating agent, is effectively used in various fluorination reactions, and is safely handled even in air. As the solution for achieving this object, the present invention provides a complex obtained by reacting bromine trifluoride with at least one metal halide selected from the group consisting of halogenated metals and halogenated hydrogen metals in a nonpolar solvent. This complex serves as a fluorinating agent that provides excellent fluorination performance and that is stable in air.

  本发明的目的是提供一种新型物质，它作为氟化剂具有高反应活性，可有效地用于各种氟化反应，即使在空气中也可安全地处理。 作为实现这一目标的解决方案，本发明提供了一种复合物，该复合物由三氟化溴与至少一种金属卤化物在非极性溶剂中反应而得，这些金属卤化物选自卤化金属和卤化氢金属组成的组。 这种络合物可用作氟化剂，具有优异的氟化性能，并且在空气中稳定。
• PAA NANOPARTICLES FOR TUMOR TREATMENT AND IMAGING
  申请人：Pandey Ravindra K.

  公开号：US20140011989A1

  公开（公告）日：2014-01-09

  A tetrapyrrolic photosensitizer and imaging compound having a substituent other than hydrogen at its 10 carbon atom which substituent may contain a PAA nanoparticle.