2,3,6a,8,9,9a-六氢-8,9a-二羟基-4-甲氧基环戊烯并(c)呋喃并(3',2':4,5)呋喃并(2,3-h)(1)苯并吡喃-1,11-二酮 | 36601-31-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 2,3,6a,8,9,9a-六氢-8,9a-二羟基-4-甲氧基环戊烯并(c)呋喃并(3',2':4,5)呋喃并(2,3-h)(1)苯并吡喃-1,11-二酮
• 英文名称: 2,3,6a,8,9,9a-Hexahydro-8,9a-dihydroxy-4-methoxycyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione
• 英文别名: 3,5-dihydroxy-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.02,9.03,7.013,17]nonadeca-1,9,11,13(17)-tetraene-16,18-dione
• CAS: 36601-31-7
• 化学式: C₁₇H₁₄O₈
• 分子量: 346.293
• InChiKey: JHYYYOLGLPXKOI-UHFFFAOYSA-N

物化性质

• 沸点：
  694.1±55.0 °C(Predicted)
• 密度：
  1.71±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  aflatoxin M1 在 三氟乙酸 作用下， 以 正己烷 为溶剂， 反应 0.33h， 生成 2,3,6a,8,9,9a-六氢-8,9a-二羟基-4-甲氧基环戊烯并(c)呋喃并(3',2':4,5)呋喃并(2,3-h)(1)苯并吡喃-1,11-二酮
  参考文献：
  名称：

  Enhanced spectrofluorimetric determination of aflatoxin M1 in liquid milk after magnetic solid phase extraction

  摘要：

  A simple and sensitive method using magnetic solid phase extraction (MSPE) followed by spectrofluorimetric detection has been developed for separation and determination of aflatoxin M-1 (AFM(1)) in liquid milk. The method is based on the extraction of AFM(1) on the modified magnetic nanoparticles (MMNPs) and subsequent derivatization of extracted AFM(1) to AFM(1) hemi-acetal derivative (AFM(2a)) by reaction with trifluoroacetic acid (TFA) for spectrofluorimetric detection. Magnetic nanoparticles (MNPs) coated by 3-(trimethoxysilyl)-1-propantiol (TMSPT) and modified with 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) were used as adsorbent in MSPE procedure. Influential parameters affecting the extraction efficiency were investigated and optimized. Under the optimum conditions the calibration curve for AFM(1) determination showed good linearity in the range 0.030-10.0 mu g L-1 (R-2 = 0.9991). The repeatability and reproducibility (RSD%) for 0.050 mu g L-1 of AFM(1) were 4.5% and 5.3%, respectively and limit of detection limit (S/N = 3) was estimated to be 0.010 mu g L-1. The developed method was successfully applied for extraction of AFM(1) from spiked liquid milk and natural contaminated liquid milk. The good spiked recoveries ranging from 91.6% to 96.1% were obtained. The results demonstrated that the developed method is simple, inexpensive, accurate and remarkably free from interference effects. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.02.108

文献信息

• Enhanced spectrofluorimetric determination of aflatoxin M1 in liquid milk after magnetic solid phase extraction
  作者：Mahdi Hashemi、Zohreh Taherimaslak、Somayeh Rashidi

  DOI：10.1016/j.saa.2014.02.108

  日期：2014.7

  A simple and sensitive method using magnetic solid phase extraction (MSPE) followed by spectrofluorimetric detection has been developed for separation and determination of aflatoxin M-1 (AFM(1)) in liquid milk. The method is based on the extraction of AFM(1) on the modified magnetic nanoparticles (MMNPs) and subsequent derivatization of extracted AFM(1) to AFM(1) hemi-acetal derivative (AFM(2a)) by reaction with trifluoroacetic acid (TFA) for spectrofluorimetric detection. Magnetic nanoparticles (MNPs) coated by 3-(trimethoxysilyl)-1-propantiol (TMSPT) and modified with 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) were used as adsorbent in MSPE procedure. Influential parameters affecting the extraction efficiency were investigated and optimized. Under the optimum conditions the calibration curve for AFM(1) determination showed good linearity in the range 0.030-10.0 mu g L-1 (R-2 = 0.9991). The repeatability and reproducibility (RSD%) for 0.050 mu g L-1 of AFM(1) were 4.5% and 5.3%, respectively and limit of detection limit (S/N = 3) was estimated to be 0.010 mu g L-1. The developed method was successfully applied for extraction of AFM(1) from spiked liquid milk and natural contaminated liquid milk. The good spiked recoveries ranging from 91.6% to 96.1% were obtained. The results demonstrated that the developed method is simple, inexpensive, accurate and remarkably free from interference effects. (C) 2014 Elsevier B.V. All rights reserved.