氯巴占EP杂质B | 22316-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 中文名称: 氯巴占EP杂质B
• 英文名称: 1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione
• 英文别名: 1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione；5-phenyl-1-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione；1-phenyl 5-methyl 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine；1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H, 5H)-dione；1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 1-methyl-5-phenyl-；1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione
• CAS: 22316-24-1
• 化学式: C₁₆H₁₄N₂O₂
• 分子量: 266.299
• InChiKey: NZZYMDHMGHIKLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氯巴占EP杂质B 生成 3-bromo-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H, 5H)-dione
  参考文献：
  名称：

  GASC, JEAN-CLAUDE;HUMBERT, DANIEL

  摘要：

  DOI：
• 作为产物：
  描述：

  1-phenyl 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine 在 sodium ethanolate 作用下， 生成 氯巴占EP杂质B
  参考文献：
  名称：

  1,5-Benzodiazepine-2,4-diones

  摘要：

  本发明涉及具有式##SPC1##的取代1,5-苯并二氮杂卓，其中R1和R2为氢或取代基，R3为氢或取代基，R4为甲基或芳基，以及其制备方法。本发明的化合物是镇静止痛、退热和抗炎药物。

  公开号：

  US03984398A1

文献信息

• Substituted heterocyclic compounds, processes and composition including
  申请人：Roussel-UCLAF

  公开号：US04001408A1

  公开（公告）日：1977-01-04

  This invention relates to substituted 1,5-benzodiazepines having the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or substituents R.sub.3 is hydrogen or substituents R.sub.4 is methyl or aryl group as well as the process of producing the same.

  本发明涉及一种具有下列式子的取代1,5-苯并二氮平类化合物：##STR1##其中R.sub.1和R.sub.2是氢或取代基，R.sub.3是氢或取代基，R.sub.4是甲基或芳基基团，以及其制备方法。
• 2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepines
  申请人：Uclaf; Roussel

  公开号：US04988692A1

  公开（公告）日：1991-01-29

  A compound in all possible isomeric forms and mixtures thereof of the formula ##STR1## wherein X and X' are individually selected from the group consisting of hydrogen, halogen, cyano, --NO.sub.2, --CF.sub.3 and alkyl and alkoxy of 1 to 8 carbon atoms, R is hydrogen or alkyl of 1 to 8 carbon atoms and Ar is selected from the group consisting of an unsubstituted or substituted aryl of 6 to 14 carbon atoms, an unsubstituted or substituted aromatic heterocyclic or a heterocyclic united with an unsubstituted or substituted aryl having cholecystokinine antagonistic activity.

  一种化合物，具有所有可能的同分异构体和其混合物，其化学式为##STR1##其中X和X'分别选自氢，卤素，氰基，--NO.sub.2，--CF.sub.3和1至8个碳原子的烷基和烷氧基的群组，R为氢或1至8个碳原子的烷基，Ar选自未取代或取代的6至14个碳原子的芳基，未取代或取代的芳香杂环或与具有胆囊收缩素拮抗活性的未取代或取代的芳基结合的杂环。
• Malonanilic derivatives
  申请人：Roussel UCLAF

  公开号：US04138572A1

  公开（公告）日：1979-02-06

  This invention relates to substituted 1,5-benzediazepines having the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or substituents R.sub.3 is hydrogen or substituents R.sub.4 is methyl or aryl group as well as the process of producing the same. The compounds of the invention are tranquillizing analgesic, antipyretic and anti-inflammatory agents.

  本发明涉及具有以下式子的取代1,5-苯并二氮平：##STR1## 其中R.sub.1和R.sub.2是氢或取代基，R.sub.3是氢或取代基，R.sub.4是甲基或芳基基团，以及其制备方法。本发明化合物是镇静止痛、退热和抗炎药物。
• ANXIOLYTIC AGENTS WITH REDUCED SEDATIVE AND ATAXIC EFFECTS
  申请人：Cook M. James

  公开号：US20070054881A1

  公开（公告）日：2007-03-08

  Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.

  本发明揭示了口服活性苯二氮平衍生物及其盐。这些化合物及其盐具有抗焦虑和抗癫痫活性，同时减少了镇静/催眠/肌肉松弛/共济失调的副作用。
• US3984398A
  申请人：——

  公开号：US3984398A

  公开（公告）日：1976-10-05