2,3-二氯丙酰胺 | 19433-84-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2,3-二氯丙酰胺
• 中文别名: 2,3二氯丙酸酯
• 英文名称: 2,3-dichloropropionamide
• 英文别名: α,β-dichloropropionamide；2,3-dichloropropanamide
• CAS: 19433-84-2
• 化学式: C₃H₅Cl₂NO
• mdl: MFCD00040311
• 分子量: 141.985
• InChiKey: SQGUQSRDWXDLIH-UHFFFAOYSA-N

物化性质

• 熔点：
  106 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  2,3-二氯丙酰胺 在 sodium hydroxide 、 对苯二酚 作用下， 以 水 为溶剂， 生成 2-氯丙烯酰胺
  参考文献：
  名称：

  Bogolyubskaya, L. T.; Bogolyubskii, A. V., Journal of Organic Chemistry USSR (English Translation), 1984, p. 1674 - 1675

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-二氯丙腈 在 硫酸 、 对苯二酚 作用下， 生成 2,3-二氯丙酰胺
  参考文献：
  名称：

  Vitamin D–receptor genotypes as independent genetic predictors of decreased bone mineral density in primary biliary cirrhosis

  摘要：

  Background & Aims: Hepatic osteodystrophy is a complication of primary biliary cirrhosis (PBC). Allelic polymorphisms of the vitamin D receptor (VDR) gene are related to bone mineral density (BMD) in normal cohorts and those with primary osteoporosis. We sought to establish the prevalence of reduced bone mass in PBC, correlate BMD with VDR gene polymorphisms, and identify risk factors for the development of hepatic osteodystrophy. Methods: Seventy-two female patients with PBC were evaluated prospectively. Clinical information, BMD assessment, disease severity, and osteoporosis risk factors were documented, and multivariate regression modeling was performed. Results: Twenty-four percent of the patients were osteoporotic at the lumbar spine and 32% at the femur. Severe bone loss (z score <-2.0) occurs 4 times more frequently in patients with PBC compared with controls. Body weight (P = 0.003) and postmenopausal status (P = 0.012) correlated independently with BMD. VDR genotype (P = 0.01) correlated with lower BMD at the spine only. Conclusions: Osteoporosis is a common complication of PBC, VDR genotype predicts lower BMD in patients with PBC. Studies are warranted to investigate the mechanism(s) by which VDR as well as other candidate genes may contribute to the development of hepatic osteodystrophy in PBC.

  DOI：

  10.1016/s0016-5085(00)70423-9

文献信息

• Aminobenzenesulfonyl-acrylamides
  申请人：Sanitized, Inc.

  公开号：US03976668A1

  公开（公告）日：1976-08-24

  A method of preventing the growth of microorganisms by contacting the microorganisms with a bioactive compound which may be described by one of the following formulas: H[(C.sub.n H.sub.2n) - A.sub.p - (C.sub.m H.sub.2m)CO].sub.k.sup.. NH C.sub.6 H.sub.4 SO.sub. 2 - CH = CH - X; ##SPC1## or R.sub.3 SO.sub.2 CH = CH - CONH.sub.2 in which A is benzene or napthalene, X is --CN, --CONH.sub.2, --COOR, --SO.sub.2 R, --SO.sub.3 R, --NO.sub.2 or --COR, R.sub.1 is an amino, acylamido or nitro group, R.sub.2 is hydrogen or a lower alkyl group, R.sub.3 is an alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or substituted cycloalkyl or a heterocyclic group and where n = 0 to 18, m = 0 to 18, m + n = 24 or less, p = 0 or 1 and k = 0 or 1.

  一种抑制微生物生长的方法，通过将微生物与生物活性化合物接触，该生物活性化合物可以用以下公式之一描述：H [（C.sub.n H.sub.2n） - A.sub.p -（C.sub.m H.sub.2m）CO] .sub.k.sup.。 NH C.sub.6 H.sub.4 SO.sub. 2 - CH = CH - X; ## SPC1 ## 或 R.sub.3 SO.sub.2 CH = CH - CONH.sub.2，其中A是苯或萘，X是-CN，-CONH.sub.2，-COOR，-SO.sub.2 R，-SO.sub.3 R，-NO.sub.2或-COR，R.sub.1是氨基，酰胺基或硝基，R.sub.2是氢或较低的烷基，R.sub.3是烷基，取代烷基，芳基，取代芳基，环烷基或取代环烷基或杂环基，其中n = 0至18，m = 0至18，m + n = 24或更少，p = 0或1，k = 0或1。
• Acylamides of beta-cyano-ethenesulfonyl substituted aminoarenes
  申请人：Sanitized Incorporated

  公开号：US03943154A1

  公开（公告）日：1976-03-09

  Acylamides of .beta.-X-ethenesulfonyl substituted aminoarenes in which the acyl moiety is an organic sulfonic, sulfinic or sulfenic acid group; an organic phosphoric, thiophosphoric, phosphonic, thiophosphonic, or phosphinic acid group; or the sulfinyl group (O=S=). Compounds within the designated class of materials are bioactive, i.e., they control the growth and activity of varying types of plant and animal organisms, e.g., microorganisms or the like.

  这段话的中文翻译如下： 这些化合物属于β-X-乙烯基磺酰取代氨基芳烃的酰胺类化合物，其中酰基是有机磺酸、亚磺酸或亚砜酸基团；有机磷酸、硫代磷酸、膦酸、硫代膦酸或膦酸酰基团；或亚砜基团（O=S=）。这一类物质具有生物活性，即它们可以控制各种植物和动物生物体的生长和活动，例如微生物等。
• Efficient .alpha.-halogenation of acyl chlorides by N-bromosuccinimide, N-chlorosuccinimide, and molecular iodine
  作者：David N. Harpp、L. Q. Bao、Catherine J. Black、John G. Gleason、Roger A. Smith

  DOI：10.1021/jo00911a026

  日期：1975.11
• Kinetics and mechanism of chlorine addition to acrylic acid and its derivatives with special reference to the nature of the transition state
  作者：R. M. Subramanian、R. Ganesan

  DOI：10.1021/jo01294a051

  日期：1980.3
• BOGOLYUBSKAYA, L. T.;BOGOLYUBSKIJ, A. V., ZH. ORGAN. XIMII, 1984, 20, N 9, 1835-1837
  作者：BOGOLYUBSKAYA, L. T.、BOGOLYUBSKIJ, A. V.

  DOI：——

  日期：——

表征谱图