氯沙坦钾EP杂质F | 1332713-64-0

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氯沙坦钾EP杂质F
• 英文名称: 5-(4'-((2-Butyl-4-chloro-5-(((1-methylethyl)oxy)methyl)-1H-imidazol-1-yl)methyl)biphenyl-2-yl)-1H-tetrazole
• 英文别名: 5-[2-[4-[[2-butyl-4-chloro-5-(propan-2-yloxymethyl)imidazol-1-yl]methyl]phenyl]phenyl]-2H-tetrazole
• CAS: 1332713-64-0
• 化学式: C₂₅H₂₉ClN₆O
• 分子量: 465.0
• InChiKey: XDTUSKVHHYIRIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  81.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ANGIOTENSIN II RECEPTOR ANTAGONISTS
  申请人：Ali Amjad

  公开号：US20100298277A1

  公开（公告）日：2010-11-25

  A compound having the structure wherein R is an angiotensin receptor blocking group Y is —(CR 1 R 20 ) 1-7 R 5 , or —C(O)(CR 1 R 20 ) 1-7 R 5 ; R 1 and R 20 are independently selected from the group consisting of hydrogen or C 1-4 alkyl; R 5 is —O—N═N(O)—NR 3 R 4 ; and R 3 and R 4 are independently selected from the group consisting of —CH 2 CH 2 OH, —CH 2 CH 2 OCH 3 , —C 1-4 alkyl, unsubstituted or substituted C 1-6 alkenyl, unsubstituted or substituted morpholino, amino, unsubstituted or substituted benzyl, unsubstituted or substituted phenyl, unsubstituted or substituted arylC 1-4 alkyl, or R 3 and R 4 together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof, which is useful for treating hypertension.
• US8106034B2
  申请人：——

  公开号：US8106034B2

  公开（公告）日：2012-01-31
• [EN] ANGIOTENSIN II RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS DE L'ANGIOTENSINE II
  申请人：MERCK & CO INC

  公开号：WO2009070241A2

  公开（公告）日：2009-06-04

  A compound having the structure (A) wherein R is an angiotensin receptor antagonist active group, and Y is 1) -(CH2)3R5, 2) -C(O)(CH2)2R5, 3) -C(R1R2)OC(O)O(CH2)nR5, wherein n is 1 or 2, 4) -C(R1R2)OC(O)CH2CH2R5, 5) -C(R1R2)OC(O)OCH2CH2C(R3R4)R5, Formula (B), and Formula (C) provided that when Y is -C(O)(CH2)2R5, then R is Formula (D) R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is CH(ONO2)CH(ONO2)R6; R6 is selected from CH3, CH2CH3 and CH(CH3)2; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.
• [EN] ANGIOTENSIN II RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES VIS-À-VIS DES RÉCEPTEURS DE L'ANGIOTENSINE II
  申请人：NICOX SA

  公开号：WO2009106470A2

  公开（公告）日：2009-09-03

  The present invention relates to nitrooxyderivatives of angiotensin II receptor antagonist having the general formula (I): where in R is selected f rom the group consisting of (IIa) - (IIk): when R is selected from (Ilk), Y is selected from the group consisting of: 1) -C(O) (CH2) nR5; 2) -C(O)(CH2n-O-CH2-R5; 3) -C(O)-R6 wherein R6 is the following group: when R is selected from (IIa)-(IIh), Y is selected from the group consisting of: 4) -C(R1R2)OC(O)-(CH2)nR5; 5) -C(R1R2)OC(O)O-(CH2)nR5; 6) C(R1R2)OC(O)(CH2)n-O-CH2-R5; 7) C(R1R2)OC(O)O(CH2)n-O-CH2-R5; 8) -C(R1R2)OC(O)-R6 wherein R6 is as above defined; R1 and R2 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is -CH(ONO2)R7; R7 is CH3 or C1-4 alkyl; n is an integer from 1 to 4; or a pharmaceutically acceptable salt thereof.
• [EN] NITROOXY DERIVATIVES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS NITROOXY EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DE L'ANGIOTENSINE II
  申请人：MERCK SHARP & DOHME

  公开号：WO2010065432A1

  公开（公告）日：2010-06-10

  A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is Y is selected from the group consisting of R1 is selected from the group consisting of -O-C 1-6 alkyl, -O-aryl, -O-heteroaryl, -O-C 3-8 cycloalkyl, -C 1-6 alkyl, -aryl, -heteroaryl, and -C 3-8 cycloalkyl; R2 and R3 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.