2,3-环氧十二烷 | 161330-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 中文名称: 2,3-环氧十二烷
• 英文名称: 2-dodecene oxide
• 英文别名: 2,3-epoxydodecane；2-nonyl-3-methyloxirane；2-Methyl-3-nonyloxirane
• CAS: 161330-44-5
• 化学式: C₁₂H₂₄O
• 分子量: 184.322
• InChiKey: HZIFNFBYOMRJRX-UHFFFAOYSA-N

物化性质

• 沸点：
  232.2±8.0 °C(Predicted)
• 密度：
  0.847±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3-环氧十二烷 在 diisopropoxytitanium(IV) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 2.1h， 以36.7%的产率得到3-chlorododecan-2-ol
  参考文献：
  名称：

  Nishitani, Kiyoshi; Shinyama, Kyoko; Yamakawa, Koji, Heterocycles, 2007, vol. 74, # C, p. 191 - 197

  摘要：

  DOI：
• 作为产物：
  描述：

  dodec-2-ene 在 2,4-bisperfluorooctylphenyl butyl selenide 、 水 、 双氧水 作用下， 以 苯 为溶剂， 以80%的产率得到2,3-环氧十二烷
  参考文献：
  名称：

  A Selenium Catalyzed Epoxidation in Perfluorinated Solvents with Hydrogen Peroxide

  摘要：

  readily prepared 2,4-bisperfluorooctylphenyl butylselenide 催化了在氟相双相体系中用过氧化氢对各种烯烃进行的环氧化反应。该催化剂在全氟化溶剂中具有选择性的溶解性，并且通过相分离可以轻松回收。此外，该催化剂可以重复使用多次，而不会降低产率或延长反应时间。

  DOI：

  10.1055/s-1999-2630

文献信息

• Selective Homologation of Ketones and Aldehydes with Diazoalkanes Promoted by Organoaluminum Reagents
  作者：Keiji Maruoka、Amel B. Concepcion、Hisashi Yamamoto

  DOI：10.1055/s-1994-25682

  日期：——

  Organoaluminum-promoted single homologation or ring expansion of ketones and aldehydes with diazoalkanes has been described, and among various organoaluminum reagents, exceptionally bulky methylaluminum bis(2,6-di-tert-butyl-4-methylphenoxide) (MAD) is found to be highly effective for the selective homologation of various ketones and aldehydes.

  介绍了一种利用重氮烷烃进行的酮和醛的一级同系化或环扩张反应，并发现，在多种有机铝试剂中，特别庞大的甲基铝双(2,6-二叔丁基-4-甲基苯氧化物)(MAD)对各种酮和醛的选择性同系化具有高度效果。
• FORMULATION AND DELIVERY OF MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20160038612A1

  公开（公告）日：2016-02-11

  The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

  本公开提供了包含修饰核酸分子的配方组合，该核酸分子可以编码蛋白质、蛋白质前体或蛋白质或蛋白质前体的部分或完全加工形式的组合物。该配方组合还可以包括一种修饰核酸分子和一种传递剂。本发明还提供了用于编码能够调节细胞功能和/或活性的多肽的核酸。
• MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
  申请人：MODERNA THERAPEUTICS

  公开号：US20130156849A1

  公开（公告）日：2013-06-20

  The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

  本公开提供了包含修改的核酸分子的配方组合，这些核酸分子可能编码蛋白质、蛋白质前体或蛋白质或蛋白质前体的部分或完全加工形式的配方组合。该配方组合还可以包括一个修改的核酸分子和一个传递剂。本发明还提供了用于编码能够调节细胞功能和/或活性的多肽的核酸。
• [EN] ISOSORBIDE-DERIVATIVES<br/>[FR] DÉRIVÉS D'ISOSORBIDE
  申请人：COGNIS IP MAN GMBH

  公开号：WO2010040464A1

  公开（公告）日：2010-04-15

  The application pertains to derivatives of isosorbide according to general formula (I) wherein R' and R' ' independently from each other represent a represent a hydrogen atom or a polymeric moiety like (CH2-CHR1-O)x-H. This polymeric moiety is composed of epoxide- based monomers, described as H2COCH-R1, where R1 represents either a hydrogen atom, in the case of ethylene oxide, or an alkyl or alkenyl moiety with 1 to 33 C-atoms, which is saturated or unsaturated, branched or linear. This polymer moiety can be a homopolymer or a copolymer, x being the total degree of polymerization (DP). In the case of a block copolymer composed of monomer A (DP = a), preferably ethylene oxide or propylene oxide and monomer B (DP = b), preferably an alkyl or alkenyl moiety with 1 to 33 C-atoms, which is saturated or unsaturated, branched or linear, x = a + b. x is zero, or a number from 1 to 50, with the proviso that R' and R" are not both hydrogen atoms.

  该申请涉及异山梨醇衍生物，其通式为（I），其中R'和R''独立地代表氢原子或聚合物基团，如（CH2-CHR1-O）x-H。该聚合物基团由环氧基单体组成，描述为H2COCH-R1，其中R1表示氢原子（在乙烯氧化物的情况下）或具有1至33个碳原子的饱和或不饱和、分支或直链的烷基或烯基基团。该聚合物基团可以是同聚物或共聚物，x为聚合度（DP）总和。在由单体A（DP = a，优选乙烯氧化物或丙烯氧化物）和单体B（DP = b，优选具有1至33个碳原子的饱和或不饱和、分支或直链的烷基或烯基基团）组成的块状共聚物的情况下，x = a + b。x为0或1至50之间的数字，但R'和R''不能同时为氢原子。
• Modified ethylene-vinyl alcohol copolymer and method for the production thereof
  申请人：——

  公开号：US20040096683A1

  公开（公告）日：2004-05-20

  Provided is a modified ethylene-vinyl alcohol copolymer (C) having an ethylen content of 5 to 55 mol %, which contains a specific structural unit (I) in an amount of 0.3 to 40 mol % and may be obtained by reacting an ethylene-vinyl alcohol copolymer (A) with a monofunctional epoxy compound (B) having a molecular weight of not more than 500. This can be produced by a method for producing the modified ethylene-vinyl alcohol copolymer (C) which comprises melting and kneading an ethylene-vinyl alcohol copolymer (A) with a monofunctional epoxy compound (B) in an extruder. The modified ethylene-vinyl alcohol copolymer (C) is superior to a unmodified ethylene-vinyl alcohol copolymer (A) in transparency, stretchability, flexibility and flexing resistance due to the specific structural unit (I) incorporated therein, and thus, can be used as a barrier material in various applications requiring the above performance capabilities.

  提供的是一种改性乙烯-醋酸乙烯共聚物(C)，其乙烯含量为5至55摩尔％，其中含有一种特定的结构单元(I)，其含量为0.3至40摩尔％，可通过将乙烯-醋酸乙烯共聚物(A)与分子量不超过500的单官能环氧化合物(B)反应而获得。该改性乙烯-醋酸乙烯共聚物(C)的制备方法包括在挤出机中熔融和揉捏乙烯-醋酸乙烯共聚物(A)与单官能环氧化合物(B)。由于其中包含了特定的结构单元(I)，改性乙烯-醋酸乙烯共聚物(C)在透明度、可伸展性、柔韧性和耐弯曲性方面优于未改性的乙烯-醋酸乙烯共聚物(A)，因此可以用作在需要上述性能能力的各种应用中的障壁材料。