2,4,5-三氯咪唑 | 7682-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2,4,5-三氯咪唑
• 英文名称: 2,4,5-Trichlorimidazol
• 英文别名: 2,4,5-Trichloroimidazole；2,4,5-trichloro-1H-imidazole
• CAS: 7682-38-4
• 化学式: C₃HCl₃N₂
• mdl: MFCD01721353
• 分子量: 171.413
• InChiKey: KCUCKJJLMMZKBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  2,4,5-三氯咪唑 以70%的产率得到
  参考文献：
  名称：

  BUECHEL K. H.; ERDMANN H., CHEM. BER. , 1976, 109, NO 5, 1625-1637

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴-4,5-二氯咪唑 生成 2,4,5-三氯咪唑
  参考文献：
  名称：

  TOMIOKA, XIROKI;XIRATA, NAONORI

  摘要：

  DOI：

文献信息

• A convenient synthesis of 4(5)-mono-, 4,5-di-, and 2,4,5-tri-substituted imidazoles
  作者：Brian Iddon、Nazir Khan

  DOI：10.1016/s0040-4039(00)84334-8

  日期：1986.1

  A procedure is described for the stepwise introduction of substituents (hydrogen included) into the imidazole ring by FGI of the bromine atoms in 1-protected 2,4,5-tribromoimidazoles in the order 2 → 5 → 4 using halogen-metal exchange techniques.

  描述了一种通过卤素-金属交换技术，通过FGI将2-被保护的2,4,5-三溴咪唑中的溴原子按2→5→4的顺序逐步引入取代基（包括氢）到咪唑环中的方法。
• [EN] 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS<br/>[FR] COMPOSES 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE POUR LE TRAITEMENT DE LA TUBERCULOSE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2005042542A1

  公开（公告）日：2005-05-12

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1)in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and -(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30)and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.

  本发明提供了一种由以下一般式表示的2,3-二氢-6-硝基咪唑[2,1-b]噁唑化合物：(1)在上述式(1)中，R1代表氢原子或C1-C6烷基，n代表0至6的整数，R1和-(CH2)nR2可以与下面的式(30)一起形成一个螺环，与相邻的碳原子一起（在下面的式中，RRR代表可能在哌啶环上具有取代基的哌啶基），(30)和R2代表苯并噻唑氧基、喹啉氧基、吡啶氧基或类似物。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型耐酸细菌具有出色的杀菌作用。
• Trihaloimidazole insecticide
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04689340A1

  公开（公告）日：1987-08-25

  The present invention relates to a trihaloimidazole derivative represented by the formula, ##STR1## wherein X and Y, being the same or different, each represent a halogen atom, and n represents an integer of 4 to 6, its production and an insecticidal composition containing it as an active ingredient.

  本发明涉及一种由以下式表示的三卤代咪唑衍生物，其中X和Y，相同或不同，分别代表卤素原子，n代表4到6的整数，其生产以及含有其作为活性成分的杀虫剂组合物。
• FLEXIBLE PIEZOELECTRIC AND FERROELECTRIC HALOIMIDAZOLE CRYSTALS
  申请人：NORTHWESTERN UNIVERSITY

  公开号：US20190127331A1

  公开（公告）日：2019-05-02

  Provided herein are substituted haloimidazole crystals, the substituted haloimidazole crystal comprising a substituted haloimidazole compound wherein the substituents are selected from the group consisting of hydrogen, an alkyl, and a halogen. The substituted haloimidazole crystals may further comprise second substituted haloimidazole. The substituted haloimidazole crystals may be piezoelectric, ferroelectric, flexible, or any combination thereof. Also provided herein are methods for preparing substituted haloimidazole crystals.

  本文提供了代替的卤代咪唑晶体，所述代替的卤代咪唑晶体包括一种代替的卤代咪唑化合物，其中取代基被选自氢、烷基和卤素的群体。代替的卤代咪唑晶体还可以包括第二代替的卤代咪唑。代替的卤代咪唑晶体可以是压电的、铁电的、柔性的或任何组合。本文还提供了制备代替卤代咪唑晶体的方法。
• Chlorinated imidazole derivatives and a process for preparing them
  申请人：Bayer Aktiengesellschaft

  公开号：US03997552A1

  公开（公告）日：1976-12-14

  Imidazole derivatives, useful as intermediates for making herbicides, having the formula ##STR1## wherein X is chlorine, lower alkyl mono- or polysubstituted by chlorine, or aryl which is optionally mono- or polysubstituted by halogen and/or lower alkyl and R.sub.1 and R.sub.2 are identical or different and are chlorine or phenyl optionally substituted by halogen and/or lower alkyl. The imidazole derivatives are prepared by converting an imidazole derivative having the formula ##STR2## wherein X' is hydrogen, lower alkyl or aryl optionally substituted by halogen atom and/or lower alkyl and R'.sub.1 and R'.sub.2 are identical and represent hydrogen and/or phenyl optionally substituted by halogen and/or lower alkyl By means of hydrogen chloride, in the absence of water, into the corresponding hydrochloride, subsequently reacting with hydrochloride with an excess of chlorine at elevated temperature.

  咪唑衍生物具有以下公式：##STR1## 其中X为氯，由氯单取代或多取代的较低烷基，或者是芳基，可选地单取代或多取代卤素和/或较低烷基，而R.sub.1和R.sub.2相同或不同，是氯或苯，可选地取代卤素和/或较低烷基。这些咪唑衍生物是制备除草剂的中间体，通过将具有以下公式的咪唑衍生物转化而来：##STR2## 其中X'为氢、较低烷基或可选地取代卤素原子和/或较低烷基的芳基，而R'.sub.1和R'.sub.2相同且表示氢和/或可选地取代卤素和/或较低烷基的苯基，通过氢氯酸的作用，在无水的情况下转化为相应的盐酸盐，随后在高温下用过量的氯反应。