2,4-二氨基噻唑盐酸盐 | 67355-26-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2,4-二氨基噻唑盐酸盐
• 中文别名: 1,3-噻唑-2,4-二胺盐酸盐
• 英文名称: 2,4-diamino thiazole
• 英文别名: 2,4-Diamino-thiazol；Thiazole-2,4-diamine；1,3-thiazole-2,4-diamine
• CAS: 67355-26-4
• 化学式: C₃H₅N₃S
• mdl: MFCD06738274
• 分子量: 115.159
• InChiKey: WKXCZMFWXZRMEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  4

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: 1,3-Thiazole-2,4-diamine, HCl
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: 1,3-Thiazole-2,4-diamine, HCl
CAS number: 67355-26-4

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C3H5N3S.ClH
Molecular weight: 151.6

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, sulfur oxides.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2,4-二氨基噻唑盐酸盐 生成 [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate;1,3-thiazole-2,4-diamine
  参考文献：
  名称：

  GEORGIEVA, R. T.;PANTEV, T. P.

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 作用下， 生成 2,4-二氨基噻唑盐酸盐
  参考文献：
  名称：

  磺胺噻唑的衍生物。

  摘要：

  DOI：

  10.1021/jo01175a027

文献信息

• 氮磷硫三元协效阻燃剂双DOPO噻唑化合物 的制备方法及其应用
  申请人：三峡大学

  公开号：CN110128474B

  公开（公告）日：2021-10-19

  本发明属于聚合物阻燃领域，具体涉及氮磷硫三元协效阻燃剂双DOPO噻唑化合物的制备方法及其应用。DOPO与2,4‑二氨基噻唑、4‑甲基‑2,5‑二氨基噻唑发生Atherton‑Todd反应生成含DOPO、噻唑结构单元的磷氮硫协同阻燃剂（BisDOPOAD、BisDOPOBF）。应用于聚氨酯及ABS等高分子树脂体系，具有与聚合物具有相容性好，储存稳定性优异，同时含磷、氮、硫三种元素，在燃烧过程中具有协同阻燃的效果，残炭率高，在树脂体系中磷含量为0.89 wt.%时，垂直燃烧等级即达UL‑94V‑0级。其原料价格合理，添加量少，且制备工艺环保简便，易于工业化生产。
• 2,4-diaminothiazoles: Tautomeric structures and acetylation-substitution studies
  作者：O. Ceder、B. Beijer

  DOI：10.1016/0040-4020(75)80109-8

  日期：——

  This is also true for the free base 1, whereas 3 has C-5 trigonal. The di- and triacetyl derivatives of 1–3 are shown to be N,N′-di- and N,N,N′-triacetyl derivatives. Ethyl 2-cyano-3-ethoxyacrylate and 2-cyano-3-ethoxyacrylonitrile react with 1 at C-5.

  NMR对2,4-二氨基噻唑1的氢卤化物及其5-甲基和5-苯基衍生物2和3的NMR研究表明，它们以具有C-5四面体的单一非芳族互变异构体形式存在。对于游离碱1也是这样，而3具有C-5三角形。的二-和三乙酰衍生物1 - 3被示出为N，N'-二-和N，N，N'-三乙酰衍生物。2-氰基-3-乙氧基丙烯酸乙酯和2-氰基-3-乙氧基丙烯腈在C-5处与1反应。
• Thiazole bis-phosphates and phosphonates, intermediates, and
  申请人：Stauffer Chemical Company

  公开号：US04086239A1

  公开（公告）日：1978-04-25

  Insecticidally active compounds are disclosed, defined by the general formula ##STR1## in which R.sup.1 is methoxy, ethoxy, or alkyl having from 1 to 10 carbon atoms; R.sup.2 is alkoxy having from 1 to 10 carbon atoms; R.sup.3 is hydrogen or phenyl; and X is sulfur or oxygen; And intermediates for the preparation of such compounds defined by the general formula ##STR2## IN WHICH R.sup.3 is as defined above.

  本发明披露了具有杀虫活性的化合物，其由一般式##STR1## 定义，其中R.sup.1是甲氧基、乙氧基或具有1至10个碳原子的烷基；R.sup.2是具有1至10个碳原子的烷氧基；R.sup.3是氢或苯基；X是硫或氧；以及用一般式##STR2##定义的制备这种化合物的中间体，其中R.sup.3如上所述。
• Studies on the reactivity of fused thiazole toward nucleophilic reagents: Synthesis of new thiazolo-derivatives of potential antischistosomal activity
  作者：Fatma M. Manhi、Madiha R. Mahmoud

  DOI：10.1002/hc.20072

  日期：——

  Schistosomiasis is considered one of the most important human helminth infection in terms of morbidity and infectivity (Chitsulo et al. Acta Trop 2000, 77, 41; Engles et al. Acta Trop 2002, 82, 139; Shelly et al. Mol Biochem Parasitol 1993, 60, 93). Derivatives of 2-amino-5-nitrothiazoles have shown activity against Schistosoma mansoni (S. mansoni) and Schistosoma haematobium (S. haematobium), but

  就发病率和传染性而言，血吸虫病被认为是最重要的人类蠕虫感染之一（Chitsulo 等人 Acta Trop 2000, 77, 41；Engles 等人 Acta Trop 2002, 82, 139；Shelly 等人 Mol Biochem9 Parasitol 19 , 60, 93)。2-氨基-5-硝基噻唑衍生物已显示出对曼氏血吸虫（S. mansoni）和血吸虫（S. haematobium）的活性，但由于它们的毒性作用，我们合成了具有噻唑部分的杂芳胺的新衍生物。所需的噻唑衍生物通过 1 和 2 制备。在这项工作中，使用两批动物测试 10 种噻唑衍生物对血吸虫病的疗效。第一批瑞士白化鼠感染曼氏链球菌，按 5 × 50 mg/kg bw 处理第二批金仓鼠感染曼氏链球菌。以 5 × 100 mg/kg bw 处理 寄生虫学参数、生化研究和肉芽肿直径。结果表明，在曼氏链球菌感染小鼠的情况下，化合物
• Ganapathi; Venkataraman, Proceedings - Indian Academy of Sciences, Section A, 1945, # 22, p. 362,376
  作者：Ganapathi、Venkataraman

  DOI：——

  日期：——