2,5-二甲基-4-(4-甲基苯基)-1,3-噻唑 | 324067-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2,5-二甲基-4-(4-甲基苯基)-1,3-噻唑
• 英文名称: 2,5-dimethyl-4-(4-methylphenyl)-1,3-thiazole
• CAS: 324067-70-1
• 化学式: C₁₂H₁₃NS
• mdl: MFCD01627876
• 分子量: 203.308
• InChiKey: NNLIFLWGVBIQHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴-4'-甲基苯丙酮 、 硫代乙酰胺 以 乙醇 为溶剂， 以58%的产率得到2,5-二甲基-4-(4-甲基苯基)-1,3-噻唑
  参考文献：
  名称：

  Characteristics of the Synthesis of Substituted and Condensed 2-Methyl-1,3-diazoles

  摘要：

  DOI：

  10.1007/s10593-005-0281-6

文献信息

• [EN] THIAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS THIAZOLIDINES EN TANT QU'ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2010004507A1

  公开（公告）日：2010-01-14

  The invention relates to thiazolidine derivatives of the formula (I) wherein A, B, and R1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially as orexin receptor antagonists.

  这项发明涉及式(I)的噻唑啉衍生物，其中A、B和R1如描述中所述，以及这些化合物的盐，特别是药学上可接受的盐，以及它们作为药物的用途，特别是作为促进睡眠的药物受体拮抗剂。
• THIAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Aissaoui Hamed

  公开号：US20110105491A1

  公开（公告）日：2011-05-05

  The invention relates to thiazolidine derivatives of the formula (I) wherein A, B, and R 1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially as orexin receptor antagonists.

  这项发明涉及式(I)的噻唑啉衍生物，其中A、B和R1如描述中所述，以及这些化合物的盐，特别是药用可接受的盐，以及它们作为药物的用途，特别是作为促进睡眠的药物受体拮抗剂。
• INK COMPOSITION, INKJET PRINTING INK, AND INKJET PRINTING METHOD
  申请人：FUJIFILM Corporation

  公开号：EP2687565A1

  公开（公告）日：2014-01-22

  Provided are an ink composition having a fastness at a high level and having an excellent grey balance in a range from a high-concentration region to a low-concentration region, an ink for inkjet recording using the ink composition, and an inkjet recording method using the ink for inkjet recording using the ink for inkjet recording. An ink composition containing at least two kinds of water-soluble long-wavelength dyes whose absorption spectrum in an aqueous solvent has a maximum wavelength of 550 nm to 700 nm, in which at least one kind of the water-soluble long-wavelength dyes is a first water-soluble long-wavelength dye of an azo compound represented by the following Formula (1), at least one kind of the water-soluble long-wavelength dyes is a second water-soluble long-wavelength dye that is different from the first water-soluble long-wavelength dye, and the second water-soluble long-wavelength dye is a compound having two to four azo groups conjugated with each other per molecule, an ink for inkjet recording using the ink composition, and an inkjet recording method using the ink for inkjet recording using the ink for inkjet recording. Formula (1): (In Formula (1), A represents a substituted or unsubstituted aryl group or a substituted or unsubstituted nitrogen-containing 5-membered heterocyclic group. G represents a nitrogen atom or -C(R2)=. R2 represents a hydrogen atom, a sulfo group, a carboxyl group, a substituted or unsubstituted carbamoyl group or a cyano group. Y2, Y3 and Y4 each independently represent a hydrogen atom or a monovalent substituent. Y2, Y3 and Y4 may be bound with each other to form a ring. All of Y2, Y3 and Y4 do not represent a hydrogen atom at the same time. M's each independently represent a hydrogen atom or a monovalent countercation.)

  本发明提供了一种在高浓度区域到低浓度区域范围内具有高牢度和优异灰平衡的墨水组合物，一种使用该墨水组合物的喷墨记录墨水，以及一种使用该墨水的喷墨记录方法。 一种墨水组合物，含有至少两种在水性溶剂中吸收光谱最大波长为 550 纳米至 700 纳米的水溶性长波长染料，其中至少一种水溶性长波长染料是由下式（1）表示的偶氮化合物的第一种水溶性长波长染料、至少一种水溶性长波长染料是不同于第一种水溶性长波长染料的第二种水溶性长波长染料，且第二种水溶性长波长染料是每个分子中具有 2 至 4 个相互共轭的偶氮基团的化合物，一种使用该墨水组合物的喷墨记录用墨水，以及一种使用该墨水组合物的喷墨记录用墨水的喷墨记录方法。 式（1）： 式（1）中，A 代表取代或未取代的芳基或取代或未取代的含氮 5 元杂环基团。R2 代表氢原子、磺基、羧基、取代或未取代的氨基甲酰基或氰基。Y2、Y3 和 Y4 各自独立地代表一个氢原子或一个一价取代基。Y2、Y3 和 Y4 可相互结合形成一个环。所有 Y2、Y3 和 Y4 不能同时代表一个氢原子。M 各独立地代表一个氢原子或一个一价取代基）。
• Ink composition, ink set and recording method
  申请人：Tojo Kaoru

  公开号：US20070109376A1

  公开（公告）日：2007-05-17

  An ink composition, which comprises: at least two kinds of water-soluble dyes each having the maximum wavelength of an absorption spectrum in an aqueous solvent of from 550 to 700 nm, wherein at least one of the at least two kinds of water-soluble dyes is selected from the group consisting of a compound represented by formula (L-1) as defined in the specification, a salt of the compound represented by formula (L-1) and a compound having a naphthalene ring substituted with at least one hydroxyl group and three or more azo groups; an ink set containing at least one kind of the ink composition; a recording method comprising applying the ink composition to a recording medium; and a recording method comprising loading the ink set on a recording apparatus, and applying the ink from the recording apparatus to a recording medium.
• INK COMPOSITION, INK FOR INKJET RECORDING AND INKJET RECORDING METHOD
  申请人：FUJIFILM Corporation

  公开号：US20140013997A1

  公开（公告）日：2014-01-16

  An ink composition containing at least two kinds of water-soluble long-wavelength dyes whose absorption spectrum in an aqueous solvent has a maximum wavelength of 550 nm to 700 nm, in which at least one kind of the water-soluble long-wavelength dyes is a first water-soluble long-wavelength dye of an azo compound represented by the following Formula (1), at least one kind of the water-soluble long-wavelength dyes is a second water-soluble long-wavelength dye that is different from the first water-soluble long-wavelength dye, and the second water-soluble long-wavelength dye is a compound having two to four azo groups conjugated with each other per molecule, an ink for inkjet recording using the ink composition, and an inkjet recording method using the ink for inkjet recording using the ink for inkjet recording. Formula (1):