2,5-脱水-3,4-二脱氧-2-硫代己糖二酸 | 17773-22-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2,5-脱水-3,4-二脱氧-2-硫代己糖二酸
• 英文名称: Tetrahydro-thiophen-2,5-dicarbonsaeure
• 英文别名: 2,3,4,5-Tetrahydro-thiophen-2,5-dicarbonsaeure；tetrahydro-thiophene-2,5-dicarboxylic acid；Thiolane-2,5-dicarboxylic acid
• CAS: 17773-22-7
• 化学式: C₆H₈O₄S
• mdl: MFCD05155225
• 分子量: 176.193
• InChiKey: VZKPHLAASBCFGX-UHFFFAOYSA-N

物化性质

• 熔点：
  144-146 °C(Solv: water (7732-18-5))
• 沸点：
  455.8±45.0 °C(Predicted)
• 密度：
  1.563±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  99.9
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  2,5-脱水-3,4-二脱氧-2-硫代己糖二酸 、 马钱子碱 生成 (-)-tetrahydrothiophene-2,5-dicarboxylic acid
  参考文献：
  名称：

  BREAU, L.;OGILVIE, W. W.;DURST, T., TETRAHEDRON LEET., 31,(1990) N, C. 35-38

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 、 sodium amalgam 、 水 作用下， 生成 2,5-脱水-3,4-二脱氧-2-硫代己糖二酸
  参考文献：
  名称：

  Ernst, Chemische Berichte, 1886, vol. 19, p. 3275

  摘要：

  DOI：

文献信息

• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS
  申请人：Chodorowski-Kimmes Sandrine

  公开号：US20100239509A1

  公开（公告）日：2010-09-23

  The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups; of a monocarboxylic acid containing 6 to 32 carbon atoms; of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and (b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

  本专利申请涉及一种化妆品或皮肤科学组合物，包括在化妆品或皮肤科学上可接受的介质中，包含以下聚合物的组合物：(a) 由以下反应得到的聚合物骨架：含有3至6个羟基的多元醇；含有6至32个碳原子的一元羧酸；至少含有两个羧基COOH的多元羧酸，和/或类似多元羧酸的环酐和/或至少含有一个羧基COOH的内酯；以及(b) 至少一个连接到所述聚合物骨架的连接基团，并能够与一个或多个配对连接基团建立H键，每个连接基团的配对涉及至少三个H（氢）键。该专利申请还涉及使用所述组合物的化妆品处理过程。
• COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION
  申请人：GIUSTINIANI Pascal

  公开号：US20090028807A1

  公开（公告）日：2009-01-29

  The present application relates to a cosmetic or pharmaceutical, in particular lipstick, composition comprising a polycondensate The application also relates to a method of cosmetic treatment using the composition, the polycondensate thus defined and a method of preparing the polycondensate.

  本申请涉及一种化妆品或药用品，特别是口红，包括聚缩酸酯的组合物。该申请还涉及一种使用该组合物进行化妆处理的方法，所述聚缩酸酯的定义以及一种制备聚缩酸酯的方法。
• COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT
  申请人：Malle Gerard

  公开号：US20100272660A1

  公开（公告）日：2010-10-28

  The present application relates to a cosmetic or pharmaceutical composition comprising a polycondensate capable of being obtained by the reaction of the following monomers alone: of 10 to 30% by weight, relative to the total weight of the polycondensate, of one or more polyols comprising 3 to 6 hydroxyl groups; of 30 to 80% by weight, relative to the total weight of the polycondensate, of one or more linear, branched and/or cyclic, saturated or unsaturated, non-aromatic monocarboxylic acids comprising 6 to 32 carbon atoms; of 1 to 40% by weight, relative to the total weight of the polycondensate, of one or more polycarboxylic acids and/or cyclic anhydrides of such a polycarboxylic acid and/or lactones comprising at least one COOH group; and optionally of 0.1 to 15% by weight, relative to the total weight of the polycondensate, of one or more silicones having a hydroxyl and/or carboxyl functional group. The application also relates to a method of cosmetic treatment using the said composition, and the polycondensate thus defined.

  本申请涉及一种化妆品或药用组合物，包括由以下单体反应而得的聚缩酸酯：相对于聚缩酸酯的总重量，占10至30%的一种或多种含有3至6个羟基的多元醇；占30至80%的一种或多种线性、支链和/或环状、饱和或不饱和、非芳香族的单羧酸，含有6至32个碳原子；占聚缩酸酯总重量的1至40%的一种或多种多羧酸和/或多羧酸的环状酐和/或含有至少一个COOH基团的内酯；以及可选地占聚缩酸酯总重量的0.1至15%的一种或多种硅氧烷，具有羟基和/或羧基官能团。该申请还涉及使用所述组合物进行化妆处理的方法，以及如此定义的聚缩酸酯。
• Psychotropic bicyclic imides
  申请人：American Home Products Corporation

  公开号：US04748240A1

  公开（公告）日：1988-05-31

  Substituted imides of the following formula are antipsychotic, anxiolytic agents with very little extrapyramidal side effects: ##STR1## in which X is --O--, --S--, --SO--, --SO.sub.2 --, --CR.sub.3 R.sub.4 --where R.sub.3 and R.sub.4, independently, are hydrogen, alkyl of 1 to 4 carbon atoms or, taken together with the carbon atom to which they are attached, R.sub.3 and R.sub.4 form a cycloalkyl group of 3 to 5 carbon atoms; Y is alkylene of 1 to 3 carbon atoms or alkenylene of 2 to 3 carbon atoms; n is one of the integers 0 to 1; m is one of the integers 2, 3, 4 or 5; R is phenyl, halophenyl, trifluoromethylphenyl, alkoxyphenyl in which the alkoxy substituent contains 1 to 3 carbon atoms, 2-pyrimidinyl, halopyrimidin-2-yl, 2-pyrazinyl, halopyrazin-2-yl, 2-pyridinyl, cyanopyridin-2-yl, halopyridin-2-yl, quinolyl, or haloquinolyl; or a pharmaceutically acceptable salt thereof.

  以下化学式中的取代亚胺类化合物是抗精神病、抗焦虑药物，具有极少的外周神经副作用：##STR1## 其中 X 是 --O--, --S--, --SO--, --SO.sub.2 --, --CR.sub.3 R.sub.4 -- 其中 R.sub.3 和 R.sub.4 分别是氢、1至4个碳原子的烷基，或与其连接的碳原子一起形成3至5个碳原子的环烷基基团；Y 是1至3个碳原子的烷基或2至3个碳原子的烯基；n 是0至1之间的整数；m 是2、3、4或5之间的整数；R 是苯基、卤苯基、三氟甲基苯基、烷氧基苯基（其中烷氧基取代基含有1至3个碳原子）、2-嘧啶基、卤嘧啶-2-基、2-吡嗪基、卤吡嗪-2-基、2-吡啶基、氰基吡啶-2-基、卤吡啶-2-基、喹啉基或卤喹啉基；或其药用可接受的盐。
• Production of thiophene-2,5-dicarboxylic acid diesters and tetrahydrothiophene-2,5-dicarboxylic acid diesters
  申请人：SUMITOMO SEIKA CHEMICALS CO., LTD.

  公开号：EP0387725A2

  公开（公告）日：1990-09-19

  There is disclosed a method of producing a thiophene-2,5-dicarboxylic acid diester represented by the formula wherein R represents an alkyl of 1-8 carbons, a phenyl, a substituted phenyl or benzyl, which comprises: halogenating a tetrahydrothiophene-2,5-dicarboxylic acid diester represented by the formula wherein R is the same as before, with a halogenating agent selected from the group consisting of halogens and sulfuryl halides in an amount of 2-4 moles per mole of the tetrahydrothiophene-2,5-dicarboxylic acid diester; and then dehydrohalogenating the resultant halogenated tetrahydrothiophene-2,5-dicarboxylic acid diester in the presence of an alcohol, a base, a metal or a metal ion. There is also disclosed a method of producing tetrahydrothiophene-2,5-dicarboxylic acid diester and dibenzoxazolyl thiophenes. Some of the thiophene-2,5-dicarboxylic acid diesters and tetrahydrothiophene-2,5-dicarboxylic acid diesters are novel.

  本发明公开了一种生产噻吩-2,5-二羧酸二酯的方法，其式为 其中R代表1-8个碳的烷基、苯基、取代苯基或苄基，该方法包括：卤化由式表示的四氢噻吩-2,5-二羧酸二酯 用从卤素和硫酰卤组成的组中选出的卤化剂，以每摩尔四氢噻吩-2,5-二羧酸二酯 2-4 摩尔的量卤化四氢噻吩-2,5-二羧酸二酯，其中 R 与前述相同；然后 在醇、碱、金属或金属离子存在下，对生成的卤代四氢噻吩-2,5-二甲酸二酯进行脱氢卤化。 还公开了一种生产四氢噻吩-2,5-二羧酸二酯和二苯并恶唑基噻吩的方法。其中一些噻吩-2,5-二羧酸二酯和四氢噻吩-2,5-二羧酸二酯是新型的。