2,6-二氨基-3-亚硝基嘧啶 | 89323-10-4

• 物质功能分类: 医药中间体 - 杂环化合物 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,6-二氨基-3-亚硝基嘧啶
• 中文别名: 2,6-二氨基-3-亚硝基吡啶；3-亚硝基吡啶-2,6-二胺
• 英文名称: 2,6-diamino-3-nitrosopyridine
• 英文别名: 3-nitroso-2,6-diaminopyridine；3-nitroso-pyridine-2,6-diyldiamine；3-Nitroso-pyridin-2,6-diyldiamin；2,6-Diamino-3-nitro-pyridin；3-nitrosopyridine-2,6-diamine
• CAS: 89323-10-4
• 化学式: C₅H₆N₄O
• mdl: MFCD00047439
• 分子量: 138.129
• InChiKey: ZURVYWKHGDMWJI-UHFFFAOYSA-N

物化性质

• 熔点：
  260-266 °C
• 沸点：
  253.51°C (rough estimate)
• 密度：
  1.3577 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.4
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2933399090

SDS

Name:	2 6-Diamino-3-Nitrosopyridine 97% Material Safety Data Sheet
Synonym:	None
CAS:	89323-10-4

Section 1 - Chemical Product MSDS Name:2 6-Diamino-3-Nitrosopyridine 97% Material Safety Data Sheet
Synonym:None

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
89323-10-4	2,6-Diamino-3-Nitropyridine	97%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.Air sensitive.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation. Place under an inert atmosphere.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Handle under an inert atmosphere. Store protected from air. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store under an inert atmosphere.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 89323-10-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Decomposes
Freezing/Melting Point: 260 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: > 260 deg C
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C5H6N4O
Molecular Weight: 138.13

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, exposure to air, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 89323-10-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2,6-Diamino-3-Nitropyridine - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 37/39 Wear suitable gloves and eye/face
protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 89323-10-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 89323-10-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 89323-10-4 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2,6-二氨基-3-亚硝基嘧啶 在 硫化氢 、 氨 作用下， 生成 N,N',N''-pyridine-2,3,6-triyl-tris-acetamide
  参考文献：
  名称：

  Petrow; Saper, Journal of the Chemical Society, <1948> 1389, 1392

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二氨基吡啶 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2,6-二氨基-3-亚硝基嘧啶
  参考文献：
  名称：

  Tschitschibabin; Seide, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920, vol. 50, p. 528

  摘要：

  DOI：

文献信息

• Synthesis of 1,2,5-Oxa-, -Thia-, and -Selenadiazole N-Oxides from Nitroso- and Isonitrosopyrimidines
  作者：A. A. Yavolovskii、V. D. Kishichenko、O. A. Oliinichenko、E. I. Ivanov

  DOI：10.1007/s11176-005-0249-3

  日期：2005.3

  The possibility of preparing 1,2,5-oxa-, -thia-, and -selenadiazole N-oxides from polyfunctional nitroso- and isonitrosopyrimidines and -pyridine was examined.

  研究了从多官能团的亚硝基和异亚硝基嘧啶及其衍生物中制备 1,2,5-氧杂、硫杂和硒杂二氮杂环 N-氧化物的可能性。
• A new fluorometric method for latamoxef in biological materials using 2,6-diamino-3-nitrosopyridine.
  作者：AKIO MATSUURA、TAKAYASU KITAGAWA、EIZO HIRAI

  DOI：10.1248/cpb.33.667

  日期：——

  A novel fluorometric assay method was established for latamoxef (LMOX), a new type of antibiotic. LMOX was converted into 1, 2, 4-dihydroxy-3-[(1-methyltetrazol-5-ylthio) methyl] but-2-enoic acid γ-lactone, in an acid solution. The lactone 1 reacted with 2, 6-diamino-3-nitrosopyridine to give the fluorophore, 3-(5-amino-3H-imidazo [4, 5-b] pyridin-2-yl)-2, 4-dihydroxybut-2-enoic acid γ-lactone. The fluorescence was measured at 460 nm with excitation at 392 nm. In plasma and urine, 1-15 μg/ml and 20-300 μg/ml of LMOX were determined, respectively, with good precision through a simple technique. The sample volume was 100 μl. The reaction mechanism of the fluorescence reaction is discussed.

  建立了新型抗生素拉氧头孢（LMOX）的荧光测定方法。LMOX 在酸性溶液中转化为 1, 2, 4-二羟基-3-[(1-甲基四唑-5-基硫基)甲基] 丁-2-烯酸 γ-内酯。内酯 1 与 2，6-二氨基-3-亚硝基吡啶反应生成荧光体 3-(5-氨基-3H-咪唑并[4，5-b] 吡啶-2-基)-2，4-二羟基丁-2-烯酸 γ-内酯。荧光在 460 纳米波长处测量，激发波长为 392 纳米波长。通过简单的技术分别测定了血浆和尿液中 1-15 μg/ml 和 20-300 μg/ml的 LMOX，精确度良好。样品量为 100 μl。讨论了荧光反应的反应机理。
• Graboyes; Day, Journal of the American Chemical Society, 1957, vol. 79, p. 6421,6423,6424
  作者：Graboyes、Day

  DOI：——

  日期：——
• The synthesis of compounds with potential anti-folic acid activity. Part IV. 3 : 6-Diaminopyrido(2 : 3)pyrazines
  作者：T. S. Osdene、G. M. Timmis

  DOI：10.1039/jr9550002032

  日期：——
• The synthesis of compounds with potential anti-folic acid activity. Part VI. Polyaza-1 : 2-benzanthracene derivatives
  作者：T. S. Osdene、G. M. Timmis

  DOI：10.1039/jr9550002214

  日期：——