2,6-双(4-甲氧基-2-甲基苯基)吡啶-4-甲醛 | 816446-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,6-双(4-甲氧基-2-甲基苯基)吡啶-4-甲醛
• 英文名称: 2,6-Bis-(4-methoxy-2-methyl-phenyl)-pyridine-4-carbaldehyde
• 英文别名: 2,6-Bis(4-methoxy-2-methylphenyl)pyridine-4-carbaldehyde；2,6-bis(4-methoxy-2-methylphenyl)pyridine-4-carbaldehyde
• CAS: 816446-68-1
• 化学式: C₂₂H₂₁NO₃
• 分子量: 347.414
• InChiKey: SWNOHEKXWDASSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,6-双(4-甲氧基-2-甲基苯基)吡啶-4-甲醛 在 lithium hydroxide 、 potassium tert-butylate 、 水 、 N,N-二异丙基乙胺 、 3-(二乙氧基邻酰氧基)-1,2,3-苯并三嗪-4-酮 作用下， 以 四氢呋喃 为溶剂， 反应 5.67h， 生成 (E)-N-Benzyl-3-[2,6-bis-(4-methoxy-2-methyl-phenyl)-pyridin-4-yl]-acrylamide
  参考文献：
  名称：

  Structural studies of biarylpyridines fluorophores lead to the identification of promising long wavelength emitters for use in fluorescent chemosensors

  摘要：

  Fluorescent chemosensors-molecules whose fluorescence emission changes in response to a reversible binding event-require both a substrate binding domain and a reporting fluorophore. Our approach to chemosensor development is based on a combination of a new signaling mechanism and a modular fluorophore synthesis. The latter feature has facilitated detailed study of the properties of polyarylpyridine fluorophores, and has led to the identification of a visibly-emissive pyridine as a promising lead structure for chemosensor development. The results of this study are described herein. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.08.049
• 作为产物：
  描述：

  Methyl 2,6-bis(4-methoxy-2-methylphenyl)pyridine-4-carboxylate 在 草酰氯 、 二异丁基氢化铝 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 生成 2,6-双(4-甲氧基-2-甲基苯基)吡啶-4-甲醛
  参考文献：
  名称：

  Structural studies of biarylpyridines fluorophores lead to the identification of promising long wavelength emitters for use in fluorescent chemosensors

  摘要：

  Fluorescent chemosensors-molecules whose fluorescence emission changes in response to a reversible binding event-require both a substrate binding domain and a reporting fluorophore. Our approach to chemosensor development is based on a combination of a new signaling mechanism and a modular fluorophore synthesis. The latter feature has facilitated detailed study of the properties of polyarylpyridine fluorophores, and has led to the identification of a visibly-emissive pyridine as a promising lead structure for chemosensor development. The results of this study are described herein. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.08.049

文献信息

• Structural studies of biarylpyridines fluorophores lead to the identification of promising long wavelength emitters for use in fluorescent chemosensors
  作者：A.G. Fang、J.V. Mello、N.S. Finney

  DOI：10.1016/j.tet.2004.08.049

  日期：2004.11

  Fluorescent chemosensors-molecules whose fluorescence emission changes in response to a reversible binding event-require both a substrate binding domain and a reporting fluorophore. Our approach to chemosensor development is based on a combination of a new signaling mechanism and a modular fluorophore synthesis. The latter feature has facilitated detailed study of the properties of polyarylpyridine fluorophores, and has led to the identification of a visibly-emissive pyridine as a promising lead structure for chemosensor development. The results of this study are described herein. (C) 2004 Elsevier Ltd. All rights reserved.